Provided is an UFB generating apparatus and an UFB generating method capable of efficiently generating an UFB-containing liquid with high purity. To this end, the ultrafine bubble generating apparatus includes a pre-processing unit that performs predetermined pre-processing on a liquid W and a generating unit that generates ultrafine bubbles in the liquid on which the pre-processing is performed. The generating unit generates the ultrafine bubbles by causing a heating element, which is provided in the liquid on which the pre-processing is performed, to generate heat to generate film boiling on an interface between the liquid and the heating element.

Embodiments of the present technology may include a method of forming an emulsion. The method may include flowing an oil stream and an aqueous stream into a coiled tube to form a mixture of an oil phase and an aqueous phase in the coiled tube. The method may also include flowing the mixture in the coiled tube against gravity and under laminar conditions. A plurality of beads may be disposed within the coiled tube. The method may further include mixing the oil phase and the aqueous phase in the coiled tube until the emulsion is formed.

Embodiments of the present technology may include a system for forming an emulsion. The system may include a coiled tube. The coiled tube may have a first end and a second end. The second end may be located at a position higher than the position of the first end. The system may also include a plurality of beads disposed within the coiled tube. The system may further include a first inlet fluidly connected to the coiled tube. The first inlet may be configured to deliver a first fluid to the first end before the second end. In addition, the system may include a second inlet fluidly connected to the coiled tube. The second inlet may be configured to deliver a second fluid to the first end before the second end.

Process for the preparation of layered particles are provided. Layered particles prepared by such processes are also provided

Process for the preparation of layered particles are provided. Layered particles prepared by such processes are also provided.

The disclosure features a system that includes a plurality of material tanks, each of which includes at least one material for forming a chemical composition and includes a first recirculation loop; at least one mixing tank in which the materials from the material tanks are mixed to form a chemical composition, the mixing tank including a second recirculation loop; and at least one holding tank configured to continuously receive the chemical composition from the mixing tank, the holding tank including a third recirculation loop. The system may further include a plurality of fluid flow controller units and be configured to form material and chemical composition flows in an in-process steady state.

An automated apparatus for preparing a liquid bioprocess solution includes at least one mixing chamber having a lower port and an upper port for fluid to enter the at least one mixing chamber, an array of tubing for fluid flow within the system, a plurality of valves provided within the tubing, and a mixing controller configured to cause the automated apparatus to perform a series of sequential mixing steps causing the preparation of the liquid bioprocess solution from a dry ingredient. The series of sequential mixing steps include opening a first valve associated with the lower port to provide fluid to the at least one mixing chamber through the lower port, and after a predetermined amount of elapsed time, closing the first valve and opening a second valve associated with the upper port to provide fluid to the at least one mixing chamber through the upper port.

Embodiments of the present application relate to batches of bupivacaine multivesicular liposomes (MVLs) prepared by a commercial manufacturing process using independently operating dual tangential flow filtration modules.

The present application provides a device (1) for dissolving in an aqueous liquid an essentially water-soluble substance, optionally comprising insoluble solid matter, and, optionally for filtering the aqueous solution of the essentially water-soluble substance to remove the insoluble solid matter. The device (1) comprises a container (2) for holding an aqueous liquid, wherein the interior of the container is divided into two separate compartments, respectively a mixing compartment (12) and a filtering compartment (14), separated by a vertically positioned filter screen (13) comprising a filter; a mixing means positioned in the mixing compartment; an outlet (17) in the lower half of one of the walls or in the base of the mixing compartment (12) for removal of the insoluble solid matter from the mixing compartment (12); a grid (4) positioned above the mixing compartment (12) comprising means for opening a bag (5) positioned on or above the grid (4), and an electronic device (20), optionally comprising a digital display, connected to a sensor (19).

Disclosed in the present invention is a rotary filtering type two-in-one stirring kettle. The stirring kettle includes a kettle body, where an upper sealing head and a lower sealing head are arranged at a top and a bottom of the kettle body respectively, a stirrer is arranged in the kettle body, and a rotary filtering mechanism is arranged between the kettle body and the lower sealing head. A back-flushing cleaning mechanism for dredging the rotary filtering mechanism is arranged at a bottom of the lower sealing head, and the rotary filtering mechanism is fixedly connected to the kettle body and the lower sealing head.