The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.

A mixing unit includes a mixing body having mixing elements that are stacked in a stacking direction and that extend in an extending direction. The mixing elements have a plurality of first through holes to form a flow path therein, and are arranged such that part or all of the first through holes in one of the mixing elements communicate with first through holes in the adjacent mixing elements to allow fluid to be passed in the direction in which the mixing element extends

A method for producing a mixture of oil and fluid food product includes placing a funnel into a pressure tank such that a stem of the funnel extends at least halfway down into the pressure tank. The pressure tank is flushed with nitrogen. Oil flows into the pressure tank through the funnel. A flow of nitrogen into the pressure tank is maintained through a side inlet of the pressure tank. Oil is dispensed from a pressure tank into the transfer line flowing a flow of fluid food product from a batch tank. The dispensed oil is dispersed into the flow of fluid food product in a inline shear mixer creating oil-in-fluid food product droplets. The oil-in-fluid food product droplets flow to the batch tank with the flow of fluid food product. The oil-in-fluid food product droplets are distributed in a volume of fluid food product in the batch tank.

A fluid acceleration system includes a housing, a rotational element, a conduit assembly, and a driver. The housing defines an inlet, an outlet, and an interior chamber configured to receive a fluid. The rotational element is disposed within the interior chamber. The rotational element includes a central support and a plurality of blades coupled to the central support. The central support extends between an upper wall and a lower wall of the housing. The conduit assembly is positioned external to the housing. The conduit assembly connects the outlet to the inlet. The driver is positioned to drive the rotational element to accelerate the fluid within the interior chamber such that a portion of the fluid flows out of the outlet, through the conduit assembly, and back into the interior chamber through the inlet.

A fluid acceleration system includes a housing, a rotational element, a conduit assembly, and a driver. The housing defines an inlet, an outlet, and an interior chamber configured to receive a fluid. The rotational element is disposed within the interior chamber. The rotational element includes a central support and a plurality of blades coupled to the central support. The central support extends between an upper wall and a lower wall of the housing. The conduit assembly is positioned external to the housing. The conduit assembly connects the outlet to the inlet. The driver is positioned to drive the rotational element to accelerate the fluid within the interior chamber such that a portion of the fluid flows out of the outlet, through the conduit assembly, and back into the interior chamber through the inlet.

A system includes a recirculation line, a mainline flow meter operable to measure a flowrate of fluid flowing through the recirculation line, a mixing chamber, an inlet line coupled between the recirculation line and the mixing chamber, at least one chemical injection port coupled to the inlet line, a dedicated feed pump operably associated with each chemical injection port, and an outlet line coupled between the mixing chamber and the recirculation line. The mixing chamber includes a plurality of mixing zones, a mixing blade assembly that includes at least one blade within each mixing zone, and a motor coupled to the mixing blade assembly and operable to rotate the mixing blade assembly. Each of the dedicated feed pumps is coupled to a separate chemical supply and is operable to pump a chemical to the corresponding chemical injection port for injection into the inlet line.

A system includes a recirculation line, a mainline flow meter operable to measure a flowrate of fluid flowing through the recirculation line, a mixing chamber, an inlet line coupled between the recirculation line and the mixing chamber, at least one chemical injection port coupled to the inlet line, a dedicated feed pump operably associated with each chemical injection port, and an outlet line coupled between the mixing chamber and the recirculation line. The mixing chamber includes a plurality of mixing zones, a mixing blade assembly that includes at least one blade within each mixing zone, and a motor coupled to the mixing blade assembly and operable to rotate the mixing blade assembly. Each of the dedicated feed pumps is coupled to a separate chemical supply and is operable to pump a chemical to the corresponding chemical injection port for injection into the inlet line.

An apparatus for stable nano emulsion of water in diesel fuel, including: a diesel fuel feeding unit (2), a water feeding unit (3), a magnetite nano-particles feeding unit (4); a mixing tank (7) in fluid communication with the diesel fuel feeding unit (2), with the water feeding unit (3) and with the magnetite nano-particles feeding unit (4); a recirculation conduit (8a, 8b, 8c, 8d) presenting opposite ends connected to the mixing tank (7). A pump (9) on the recirculation conduit (8a, 8b, 8c, 8d) and configured to recirculate a mixture of diesel fuel (F), water (W) and magnetite nano-particles (MNP). A dynamic magnetic field generator (25) is operationally coupled to the recirculation conduit (8a, 8b, 8c, 8d) and is configured to generate a dynamic magnetic field inside at least a section of the recirculation conduit (8a, 8b, 8c, 8d) to activate the magnetite nano-particles.

An apparatus for stable nano emulsion of water in diesel fuel, including: a diesel fuel feeding unit (2), a water feeding unit (3), a magnetite nano-particles feeding unit (4); a mixing tank (7) in fluid communication with the diesel fuel feeding unit (2), with the water feeding unit (3) and with the magnetite nano-particles feeding unit (4); a recirculation conduit (8a, 8b, 8c, 8d) presenting opposite ends connected to the mixing tank (7). A pump (9) on the recirculation conduit (8a, 8b, 8c, 8d) and configured to recirculate a mixture of diesel fuel (F), water (W) and magnetite nano-particles (MNP). A dynamic magnetic field generator (25) is operationally coupled to the recirculation conduit (8a, 8b, 8c, 8d) and is configured to generate a dynamic magnetic field inside at least a section of the recirculation conduit (8a, 8b, 8c, 8d) to activate the magnetite nano-particles.

A polymer flocculant mixing and dissolving system comprising: a mixing tank (2) in which a solid polymer flocculant is mixed with water used as a solvent; a liquid feed unit (3) for feeding an aqueous solution containing the polymer flocculant from the mixing tank; a regenerative mixer (4A,4B) used to mix and dissolve the polymer flocculant by applying pressure to the aqueous solution containing the polymer flocculant fed from the liquid feed unit while forming a vortex flow; a process channel (61) through which the aqueous solution that has passed through the regenerative mixer is fed to a downstream process; a circulation channel (62) through which the aqueous solution is returned to a position on an upstream side of the liquid feed unit; and a flow rate adjusting unit (6) for adjusting a balance between a flow rate of the aqueous solution flowing through the process channel and a flow rate of the aqueous solution flowing through the circulation channel. The polymer flocculant mixing and dissolving system can stably supply the solution in an amount required in the downstream process.