A single stage clarifier and mixing assembly includes a housing, a mixing section within the housing and a clarifier section within the housing. The mixing section includes a mixing chamber having (a) an inlet, adapted for delivering an inlet stream to the mixing chamber, at an upper end, and (b) a mixing section outlet at a lower end. The clarifier section extends concentrically around the mixing section. The single stage clarifier and mixing assembly also includes an agitator adapted for mixing the inlet stream in the mixing chamber.

A single stage clarifier mixing assembly includes a housing having a circular sidewall and a center axis, a mixing section in the housing, a clarifier section overlying and axially aligned with the mixing section along the center axis within the housing, an inlet delivering an inlet stream to the mixing section and an agitator. The agitator is adapted for mixing the inlet stream in the mixing chamber.

In an embodiment, a reactor for carrying out a melt transesterification reaction at a reactor temperature of 160 to 300 C. and a reactor pressure of 5 to 200 mbar, comprises a cylindrical tank comprising a top, a side, and a bottom, wherein the bottom is convex, extending away from the top; a stirring shaft disposed within the cylindrical tank along an axis thereof so that it is rotatable from outside of the cylindrical tank; an impeller extending from the stirring shaft in the cylindrical tank and comprising a plurality of blades; a reactant solution inlet; a reaction solution outlet; and an externally located heat exchanger in fluid communication with the cylindrical tank via a recirculation stream and a heated stream. The reactor can be used for the polymerization of a polycarbonate oligomer.

In an embodiment, a reactor for carrying out a melt transesterification reaction at a reactor temperature of 160 to 300 C. and a reactor pressure of 5 to 200 mbar, comprises a cylindrical tank comprising a top, a side, and a bottom, wherein the bottom is convex, extending away from the top; a stirring shaft disposed within the cylindrical tank along an axis thereof so that it is rotatable from outside of the cylindrical tank; an impeller extending from the stirring shaft in the cylindrical tank and comprising a plurality of blades; a reactant solution inlet; a reaction solution outlet; and an externally located heat exchanger in fluid communication with the cylindrical tank via a recirculation stream and a heated stream. The reactor can be used for the polymerization of a polycarbonate oligomer.

A single-use bioreactor is provided. The single-use bioreactor may include a bioprocess container, a shell, at least one agitator, at least one sparger, at least one gas filter inlet port for the sparger(s) and headspace overlay, at least one fill port, at least one harvest port, at least one sample port, and at least one probe. In examples, at least one controller may monitor and control one or more parameters associated with the single-use bioreactor A method to cultivate and propagate mammalian cells is also provided. The method may include cultivating under suitable conditions and in a suitable culture medium in a first single-use bioreactor, transferring the medium containing the cells obtained by propagation from the at least one mammalian cell is into a second single-use bioreactor, transferring the medium containing the cells obtained by propagation from the at least one mammalian cell is into a third single-use bioreactor, and cultivating the cells in the third bioreactor.

A blending system is shown and described herein. The blending system may include a base including a motor, a blade assembly selectively and operably engaged with the base, where the motor drives the blade assembly, and a container having a cavity. The container includes a flute protruding from an inner surface. An exaggerated flute may extend closer to the blade assembly than the flute.

A single-use bioreactor is provided. The single-use bioreactor may include a bioprocess container, a shell, at least one agitator, at least one sparger, at least one gas filter inlet port for the sparger(s) and headspace overlay, at least one fill port, at least one harvest port, at least one sample port, and at least one probe. In examples, at least one controller may monitor and control one or more parameters associated with the single-use bioreactor A method to cultivate and propagate mammalian cells is also provided. The method may include cultivating under suitable conditions and in a suitable culture medium in a first single-use bioreactor, transferring the medium containing the cells obtained by propagation from the at least one mammalian cell is into a second single-use bioreactor, transferring the medium containing the cells obtained by propagation from the at least one mammalian cell is into a third single-use bioreactor, and cultivating the cells in the third bioreactor.

Method and apparatus for continuous processing to perform chemical or physical reactions comprises a tube in which internal axial stirrer blades mounted at the periphery of the tube are driven by a drive system. This generates tangential flow of material at the perimeter. Stationary axial baffles mounted inside the swept path of the stirrer blades convert tangential flow into turbulence and radial mixing.

Method and apparatus for continuous processing to perform chemical or physical reactions comprises a tube in which internal axial stirrer blades mounted at the periphery of the tube are driven by a drive system. This generates tangential flow of material at the perimeter. Stationary axial baffles mounted inside the swept path of the stirrer blades convert tangential flow into turbulence and radial mixing.

The present disclosure provides an apparatus for extracting resin from plant material, comprising an agitation tank having an open top and an outlet at a bottom thereof, a strainer basket installed within the agitation tank, the strainer basket comprising walls constructed from a mesh material selected based on a type of plant material to be processed, and an agitator comprising a motor which turns a shaft and two impellers mounted on the shaft. The present disclosure also provides a process for extracting resin from plant material, comprising placing a quantity of plant material within a strainer basket comprising walls constructed from a mesh material, submersing the strainer basket in a tank filled with chilled water at a temperature in the range of 0-10 Celsius, agitating the plant material and chilled water within the strainer basket to separate trichomes from the plant material, and removing a mixture of water and trichomes from an outlet at the bottom of the tank.