The present set of embodiments relate to a bioproduction system, method, and apparatus for creating a scalable bioreactor system. Specifically, the present set of embodiments enable the determination of bioreaction performance characteristics of a commercial scale by matching operational parameters between a small test scale bioreaction to that of a commercial scale bioreaction. The system and methods do not rely on simply making bioreactor apparatuses across scales the same dimensionally which would not account for differences in fluid dynamic properties between very small to very large volumes, but requires tuning of a variety of systems (mixing assembly, sparger system, and headspace airflow system) in conjunction with one another to achieve predictive outcomes.

The present set of embodiments relate to a bioproduction system, method, and apparatus for creating a scalable bioreactor system. Specifically, the present set of embodiments enable the determination of bioreaction performance characteristics of a commercial scale by matching operational parameters between a small test scale bioreaction to that of a commercial scale bioreaction. The system and methods do not rely on simply making bioreactor apparatuses across scales the same dimensionally which would not account for differences in fluid dynamic properties between very small to very large volumes, but requires tuning of a variety of systems (mixing assembly, sparger system, and headspace airflow system) in conjunction with one another to achieve predictive outcomes.

A stirring device includes: a stirring tank that accommodates a fluid; a fluid blade that is rotated to make the fluid flow in the stirring tank; and a stirring blade that is provided between a bottom portion of the stirring tank and the fluid blade, is rotated to stir the fluid, and includes a substantially-plate-shaped blade portion that extends from a rotary shaft of the stirring blade to a side wall of the stirring tank, in which a normal direction of a stirring surface of the substantially-plate-shaped blade portion is inclined with respect to both an axial direction of the rotary shaft and a rotation direction of the blade portion, and a blade diameter of the substantially-plate-shaped blade portion in an extension direction is between about 50% and 70% of a tank diameter of the stirring tank.

A stirring device includes: a stirring tank that accommodates a fluid; a fluid blade that is rotated to make the fluid flow in the stirring tank; and a stirring blade that is provided between a bottom portion of the stirring tank and the fluid blade, is rotated to stir the fluid, and includes a substantially-plate-shaped blade portion that extends from a rotary shaft of the stirring blade to a side wall of the stirring tank, in which a normal direction of a stirring surface of the substantially-plate-shaped blade portion is inclined with respect to both an axial direction of the rotary shaft and a rotation direction of the blade portion, and a blade diameter of the substantially-plate-shaped blade portion in an extension direction is between about 50% and 70% of a tank diameter of the stirring tank.

An exhaust-gas treatment arrangement for an exhaust system of an internal-combustion engine includes a diesel internal-combustion engine. The arrangement includes a first exhaust-gas treatment unit and, downstream of the first exhaust-gas treatment unit, an exhaust-gas treatment assembly. The first exhaust-gas treatment unit and the exhaust-gas treatment assembly are arranged axially succeeding one another in the direction of a longitudinal axis of a flow path encompassing the first exhaust-gas treatment unit and the exhaust-gas treatment assembly. A hydrocarbon-feeding assembly is provided for feeding hydrocarbon into exhaust gas flowing in the flow path. The hydrocarbon-feeding assembly includes a hydrocarbon-dispensing unit dispensing hydrocarbon into the flow path downstream of the first exhaust-gas treatment unit and upstream of the exhaust-gas treatment assembly. A swirl-flow-generating unit is provided in the flow path upstream of the hydrocarbon-dispensing unit.

An exhaust-gas treatment arrangement for an exhaust system of an internal-combustion engine includes a diesel internal-combustion engine. The arrangement includes a first exhaust-gas treatment unit and, downstream of the first exhaust-gas treatment unit, an exhaust-gas treatment assembly. The first exhaust-gas treatment unit and the exhaust-gas treatment assembly are arranged axially succeeding one another in the direction of a longitudinal axis of a flow path encompassing the first exhaust-gas treatment unit and the exhaust-gas treatment assembly. A hydrocarbon-feeding assembly is provided for feeding hydrocarbon into exhaust gas flowing in the flow path. The hydrocarbon-feeding assembly includes a hydrocarbon-dispensing unit dispensing hydrocarbon into the flow path downstream of the first exhaust-gas treatment unit and upstream of the exhaust-gas treatment assembly. A swirl-flow-generating unit is provided in the flow path upstream of the hydrocarbon-dispensing unit.

A slurry mixing apparatus includes: an agitator in a ceiling part of the slurry mixing apparatus and configured to revolve about a revolution axis thereof while rotating about a first rotation axis thereof; a distributor in the ceiling part of the slurry mixing apparatus and configured to revolve about the revolution axis while rotating about a second rotation axis; a driver configured to provide a rotational force to the agitator and the distributor; a container configured to accommodate a slurry to be mixed by the agitator and the distributor; and a liquid supply part in at least one of the ceiling part, the agitator, the distributor, and the container and configured to provide a liquid.

A slurry mixing apparatus includes: an agitator in a ceiling part of the slurry mixing apparatus and configured to revolve about a revolution axis thereof while rotating about a first rotation axis thereof; a distributor in the ceiling part of the slurry mixing apparatus and configured to revolve about the revolution axis while rotating about a second rotation axis; a driver configured to provide a rotational force to the agitator and the distributor; a container configured to accommodate a slurry to be mixed by the agitator and the distributor; and a liquid supply part in at least one of the ceiling part, the agitator, the distributor, and the container and configured to provide a liquid.

A bioproduction mixing system includes a flexible compartment having a first end, a second end, and a sidewall extending therebetween, a center axis passing through the flexible compartment between the first end and the second end. A helical assembly is disposed within the flexible compartment and is suspended between the first end and the second end, the helical assembly being offset from the center axis of the flexible compartment.

A bioproduction mixing system includes a flexible compartment having a first end, a second end, and a sidewall extending therebetween, a center axis passing through the flexible compartment between the first end and the second end. A helical assembly is disposed within the flexible compartment and is suspended between the first end and the second end, the helical assembly being offset from the center axis of the flexible compartment.