A method of processing a sample in a receptacle comprising a plurality of chambers. Each of the chambers is connected to at least one other chamber by a portal and at least a first one of the chambers is formed of a flexible material. The method includes the steps of causing gas bubbles contained in the first chamber to accumulate in a portion of the first chamber, applying a compressive external force to the first chamber to cause some or all of the liquid contents of the first chamber to flow into an interconnected second chamber through a portal connecting the first and second chambers; and preventing the gas bubbles accumulated in a portion of the first chamber from flowing through the portal into the second chamber

A toilet apparatus has a waste material receiving bowl with an opening to receive an absorbent media and indicator and a sensor to detect a presence of the indicator in the material receiving bowl when the indicator is present in the material receiving bowl and transmit a signal indicating the indicator is present in the material receiving bowl. A control circuit receives the signal from the sensor, processes the signal to determine the indicator is present in the material receiving bowl, and causes one or more actions to be taken by the toilet apparatus based on determining the indicator is present in the material receiving bowl.

A biological cell preservation or culturing arrangement (20) comprises a chamber defining a fluid retaining space (30) for retaining in use a body of fluid (34) and a deformable membrane (36) in communication with the fluid retaining space, and being manipulable by an electroactive polymer actuator arrangement (38) to undergo a defined topology change to induce in the fluid a pattern of fluid flow by which fluid is exchanged between a sub-region (46) immediately proximal the deformable membrane and a sub-region (48) removed from the deformable membrane.

A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample. The detector can be used to detect an optical signal emitted by the contents of the receptacle.

A toilet apparatus has a waste material receiving bowl with an opening to receive an absorbent media and indicator and a sensor to detect a presence of the indicator in the material receiving bowl when the indicator is present in the material receiving bowl and transmit a signal indicating the indicator is present in the material receiving bowl. A control circuit receives the signal from the sensor, processes the signal to determine the indicator is present in the material receiving bowl, and causes one or more actions to be taken by the toilet apparatus based on determining the indicator is present in the material receiving bowl.

The present invention relates to devices and methods for the detection of analytes. In particular, the invention relates to methods for the qualitative and/or quantitative detection of analytes, comprising a microarray on a substrate, onto which probe molecules are immobilized on array elements, said microarray being disposed on a first surface of the device; and a detection chamber formed between the first surface including the microarray disposed thereon and a second surface, wherein the distance between the microarray and the second surface is variable, and wherein the second surface has a displacement structure.

The subject of the present invention is a microfluidic circuit in which are defined microchannels able to contain fluids and including at least one device for forming drops of a solution, guiding the drops to a storage zone in which one of the drops can be brought into contact with a drop of another solution, the walls of the microchannel portion forming the first drop-formation device diverging so as to cause drops of the first solution to detach under the effect of the surface tension of the first solution; the first guide include wall portions of the microchannels that diverge so as to cause the drops to move along under the effect of the surface tension of the first solution.

A mixing machine configured to receive a receiving device in order to form a mixing machine, the manufacturing apparatus comprising: a support defining a receiving housing, having a first receiving location configured to receive a first deformable capsule and a second receiving location configured to receive a second deformable capsule, the first and second capsules fluidly linked and respectively containing a first formulation and a second formulation, an actuation system movable relative to the support inside the receiving housing, comprising a first actuation member positioned on one side of the receiving housing and movable thereinside, in order to transmit a pressure force on the first capsule, along a first actuation stroke, a second actuation member positioned on another side, preferably an opposite side, of the receiving housing and movable thereinside, in order to transmit a pressure force on the second capsule, along a second actuation stroke, in which the first actuation stroke has a different length from the second actuation stroke.

A mixing machine configured to receive a receiving device in order to form a mixing machine, the manufacturing apparatus comprising: a support defining a receiving housing, having a first receiving location configured to receive a first deformable capsule and a second receiving location configured to receive a second deformable capsule, the first and second capsules fluidly linked and respectively containing a first formulation and a second formulation, an actuation system movable relative to the support inside the receiving housing, comprising a first actuation member positioned on one side of the receiving housing and movable thereinside, in order to transmit a pressure force on the first capsule, along a first actuation stroke, a second actuation member positioned on another side, preferably an opposite side, of the receiving housing and movable thereinside, in order to transmit a pressure force on the second capsule, along a second actuation stroke, in which the first actuation stroke has a different length from the second actuation stroke.

The present invention relates to devices and methods for the qualitative and/or quantitative detection of particles. In particular, the invention relates to devices for the detection of particles, comprising a reaction chamber formed within a chamber body between a first surface and a second surface, wherein the second surface is located opposite to the first surface, and one or more displacers, wherein the distance between the first surface and the second surface is variable via the one or more displacers at least in one or more parts of the surface area of the first surface and/or second surface. The invention also relates to corresponding methods for the detection of particles.