Provided in one implementation is a method that includes introducing a volume of raw material into a chamber of a cavitation machine. The raw material can include a mixture comprising a powder and a solvent. The powder can have a first average particle size in the raw material. The method includes applying a hydrodynamic cavitation process to the raw material to produce a product material. The powder can have a second average particle size, smaller than the first average particle size, in the product material. The method includes causing the product material to exit the cavitation chamber and drying the product material to remove the solvent. Apparatus employed to apply the method are also provided.

Mixing device (1) and fluid mixing method, by means of successive transfers between syringes. The mixing method comprises placing a pair of syringes (2, 3) in the mixing device (1), adjusting a variable fixing element adaptable to the pair of syringes (2, 3) and selecting and running a mixing programme, being the mixing force, the speed and the range and the number of transfers adjustable. The mixing device comprises a mobile carriage (7) longitudinally movable and fixing elements (8, 9) with an adjustable distance between them. The invention allows for the mixing or emulsifying of blood fluids with different viscosity, particularly a protein gel and a platelet-rich plasma, for the preparation of dermatological formulations, in a versatile, hygienic and effective manner.

The invention relates to a method for processing a liquid sample situated in a receptacle, wherein an attachment device is attached to the receptacle such that at least one fluid line protrudes into the liquid sample and a fluid is directly dispensed into the liquid sample through the fluid line and/or a portion of the liquid sample is aspirated into the fluid line.

An analysis system may perform operations on an analyte that may be combined with multiple regents prior to being introduced into a flow cell. The instrument may include a volume into which the reagents to be combined with the analyte are aspirated one-by-one. The volume may be formed as a serpentine channel in a valve manifold associated with sippers for aspirating the reagents. The reagents may then be mixed by cycling a pump to move the reagents within the mixing volume or channel. For this, the reagents may be aspirated from a recipient into the volume or channel, ejected back into the recipient, and this process may be performed repeatedly to enhance mixing.

Provided in one implementation is a method that includes introducing a volume of raw material into a chamber of a cavitation machine. The raw material can include a mixture comprising a powder and a solvent. The powder can have a first average particle size in the raw material. The method includes applying a hydrodynamic cavitation process to the raw material to produce a product material. The powder can have a second average particle size, smaller than the first average particle size, in the product material. The method includes causing the product material to exit the cavitation chamber and drying the product material to remove the solvent. Apparatus employed to apply the method are also provided.

Provided is a container for preparing a diluted solution of a biological sample to be used for biological sample analysis. Specifically, provided is a container for specimen dilution, including: an open; a first bottom; a second bottom formed on an inner side wall of the container; and a groove upwardly formed, on the inner side wall of the container, from the second bottom, in which the groove has a constant width equal to a width of the second bottom, or the groove has, at a lower end thereof, a width equal to the width of the second bottom and upwardly widens.

In one embodiment described herein, a cartridge is provided comprising a cartridge frame; a plurality of diluents each in an expandable container; a plurality of reagents each in an expandable container; and a plurality of mixing vessels comprising empty expandable containers.

Devices and methods for preparing a slurry for coating onto a substrate. The devices and methods of the present disclosure relate to providing a slurry in a closed volume with at least one passage. The slurry includes a solvent, a powder, and a binder. The slurry can also include a dispersion agent. The slurry is forced repeatedly under high pressure through the at least one passage in a first flow direction and then back through the at least one passage in a second flow direction, opposite the first flow direction. The forcing homogenously disperses the powder and the binder within the solvent. Both sides of the substrate are then coated simultaneously with the slurry extruded from the closed volume after the forcing. Curing of the coated slurry includes freeze drying to preserve the porosity of the slurry on the substrate.

Microfluidic devices, systems, and methods for mixing a solution are disclosed, comprising a microfluidic device (100) having a first chamber (110) connected via a connection channel to a second chamber (116) that in operation is only in fluidic communication with the first chamber of the device (100). In the method, solution in the first chamber (110) is forced into the second chamber (116), compressing the air trapped within the second chamber (116), and then that solution is returned to the first chamber (110). On return to the first chamber (110), the solution exits the connecting channel (115) and causes mixing in the first chamber (110).

A mechanism for collecting a trace of a biological sample to be used for a biological sample analysis, and for preparing a diluted solution of the sample. A container for specimen preparation includes: a biological sample collecting device; and a container for sample dilution. The biological sample collecting device includes: a capillary tube having openings formed at both ends thereof; and a support member for supporting the capillary tube. The container for sample dilution includes: an opening; and a swirl flow generating member formed on an inner wall of the container for sample dilution. The capillary tube of the biological sample collecting device is arranged inside the container for sample dilution by the support member.