An ultrasonic system for homogenizing a sample includes an ultrasonic transducer and a control system. The transducer includes a horn or other probe that oscillates to produce cavitation in the sample and a converter that drives the horn through its oscillatory motion. The control system includes a closed-loop amplitude-control configuration and process. In particular, the control system includes a user interface, a controller, and a high-frequency driver, all connected together in a closed-loop configuration for enabling amplitude-control feedback. Control software includes programming for the closed-loop amplitude-control process including receiving a user-inputted desired amplitude of oscillatory horn motion, driving the transducer at a corresponding power level, determining the actual amplitude of oscillatory horn motion, and automatically adjusting the power level to the transducer to maintain the desired amplitude during operation of the ultrasonic system.

Systems, devices, and methods for kinetic release testing of compounds are discussed herein. Ultrasonic agitation, with resultant cavitation and acoustic streaming, is used to breakdown and release drugs from one or more compounds to form a solution. The system uses small volumes of solvent to increase accessibility and portability of the system. Once dissolved, the solution is passed to a sampling system for calculating kinetic release behavior. The kinetic release behavior can be compared to existing reference data to identify the compound and/or confirm accurate manufacture by comparison of dissolution characteristics of the active ingredients. In some embodiments, streak photography and hydrophone measurements are used to study the effects of system parameters on the acousto-hydrodynamic environment.

A bioFET device includes a semiconductor substrate having a first surface and an opposite, parallel second surface and a plurality of bioFET sensors on the semiconductor substrate. Each of the bioFET sensors includes a gate formed on the first surface of the semiconductor substrate and a channel region formed within the semiconductor substrate beneath the gate and between source/drain (S/D) regions in the semiconductor substrate. The channel region includes a portion of the second surface of the semiconductor substrate. An isolation layer is disposed on the second surface of the semiconductor substrate. The isolation layer has an opening positioned over the channel region of more than one bioFET sensor of the plurality of bioFET sensors. An interface layer is disposed on the channel region of the more than one bioFET sensor in the opening.

Gaseous nanobubbles are created and infused into the blood stream to therapeutic effect such as oxygenation. The nanobubbles may be created inside or outside of the patient, either during infusion or prior to infusion. CO2 is extracted from the blood to improve oxygen.

A dental irrigation device for heating a solution and mixing solutes within the solution. The present invention utilizes an oscillator and inductive coil to heat and/or mix the solution. A pump then delivers the heated and mixed pressurized solution from a basin ultimately into a dispenser.

A mixing apparatus includes a phosphoric acid aqueous solution supply, an additive supply, a tank, a phosphoric acid aqueous solution supply path and an additive supply path. The phosphoric acid aqueous solution supply is configured to supply a phosphoric acid aqueous solution. The additive supply is configured to supply an additive configured to suppress precipitation of a silicon oxide. The phosphoric acid aqueous solution supply path is configured to connect the phosphoric acid aqueous solution supply with the tank. The additive supply path is configured to connect the additive supply with the tank. The additive is supplied while fluidity is imparted to the phosphoric acid aqueous solution supplied from the phosphoric acid aqueous solution supply into the tank.

Devices, systems, and their methods of use, for generating droplets are provided. One or more geometric parameters of a microfluidic channel can be selected to generate droplets of a desired and predictable droplet size.

Provided is an UFB generating apparatus and an UFB generating method capable of efficiently generating an UFB-containing liquid with high purity. The ultrafine bubble generating apparatus includes a generating unit that generates ultrafine bubbles in a liquid and a post-processing unit that performs predetermined post-processing on the ultrafine bubble-containing liquid generated by the generating unit. The generating unit generates the ultrafine bubbles by causing a heating element, which is provided in the liquid on which the pre-processing is performed, to generate heat to generate film boiling on an interface between the liquid and the heating element.

Provided is an UFB generating apparatus and an UFB generating method capable of efficiently generating an UFB-containing liquid with high purity. To this end, the ultrafine bubble generating apparatus includes a pre-processing unit that performs predetermined pre-processing on a liquid W and a generating unit that generates ultrafine bubbles in the liquid on which the pre-processing is performed. The generating unit generates the ultrafine bubbles by causing a heating element, which is provided in the liquid on which the pre-processing is performed, to generate heat to generate film boiling on an interface between the liquid and the heating element.

An exemplary embodiment of the present invention provides a urea water manufacturing device which can reduce the time for producing urea water by forming a vibrating atmosphere using an ultrasonic wave generator when stirring urea and pure water supplied inside a stirring tank, and can produce urea water with high purity by real-time feedback control of specific gravity of urea water, and a method thereof. The urea water manufacturing device according to an exemplary embodiment of the present invention includes a pure water supply unit, a urea supply unit, a stirring unit, a specific gravity detection unit, a control unit, and a urea water discharge unit.