Proposed are an automated microreactor for effective optimization of a high-speed chemical reaction, and a method of optimizing a high-speed chemical reaction using the same. The automated microreactor includes a raw material supply unit including a plurality of flow rate controllers that supply a plurality of raw materials and control flow rates of the plurality of raw materials, an intermediate reaction unit including a plurality of micromixers for intermediate that generate a first mixture and a plurality of tubular reactors for intermediate that generate an intermediate product, an intermediate reaction control unit including a valve member, and a product reaction unit including a product micromixer that produces a second mixture and producing a product, through which optimal synthesis conditions (optimal temperature, flow rate, reaction volume and organolithium reagent type) can be achieved to obtain the highest yield in a short time.

An adapter for connecting one or more storage containers with a syringe is described. The adapter includes a first port that provide a connection with a first container volume, a second port that provides a connection with a second container volume, a third port that provides a connection to a syringe. The adapter further includes a mixing channel extending from a first end in fluid communication with the third port to a second end. The mixing channel includes a tortuous path along at least a portion of its length. The mixing channel enables two constituents of a pharmaceutical complex to be mixed through the mixing channel to form the pharmaceutical complex. Also disclosed is a system including such an adapter, a method of mixing two constituents of a pharmaceutical complex via such an adapter and a method of manufacturing such an adapter.

An adapter for connecting one or more storage containers with a syringe is described. The adapter includes a first port that provide a connection with a first container volume, a second port that provides a connection with a second container volume, a third port that provides a connection to a syringe. The adapter further includes a mixing channel extending from a first end in fluid communication with the third port to a second end. The mixing channel includes a tortuous path along at least a portion of its length. The mixing channel enables two constituents of a pharmaceutical complex to be mixed through the mixing channel to form the pharmaceutical complex. Also disclosed is a system including such an adapter, a method of mixing two constituents of a pharmaceutical complex via such an adapter and a method of manufacturing such an adapter.

There is disclosed a capillary microfluidic circuit including a main channel communicating with a flow inducing element. The main channel has intermediary inlets. Reservoirs for containing one or more liquids prior to being drawn into the main channel. The reservoirs include a first reservoir and at least a second reservoir. Each of the reservoirs has an upstream end connectable to vents for filling the reservoirs with the one or more liquids and a downstream end. The downstream end of each of the reservoirs is connected to the intermediary inlets of the main channel A conduit is disposed between the first reservoir and the a least a second reservoir. The conduit links the downstream end of the first reservoir with the upstream end of the at least a second reservoir.

An exemplary compounding system and method can include a transfer set that includes a manifold for assisting in transferring a plurality of ingredients from supply container(s) to a final container. The manifold can include a first channel in fluid communication with at least one primary ingredient, and a second channel in fluid communication with a plurality of secondary ingredients. The first channel and second channel can be in fluid isolation from each other such that the at least one primary ingredient does not mix with the plurality of secondary ingredients within the manifold. The transfer set can include a plurality of inlet lines in fluid communication with the manifold and two outlet lines configured for connection to two separate pumps and eventually being in fluid communication with the final container.

An embodiment for a microfluidic device is provided. The device comprises two areas, arranged side-by-side, and a trigger channel. They include a first area, which is delimited by a first liquid pinning barrier, and a second area, which is delimited by a second liquid pinning barrier. The latter extends parallel to the first liquid pinning barrier to delimit a corridor. The trigger channel extends through the corridor between the two areas. In addition, the trigger channel connects the first liquid pinning barrier with the second liquid pinning barrier, allowing a first liquid pinned at the first liquid pinning barrier and a second liquid pinned at the second liquid pinning barrier to be contacted, each, by a reverse flow of the second liquid in the trigger channel and thereby start mixing at a level of the corridor, in operation. The invention is further directed to related methods of operation.

An apparatus and method for simple, low power, automated processing of biological samples through multiple preparation and assay steps. The apparatus and methods described facilitate the point-of-care implementation of diagnostic assays. The apparatus includes mechanical actuating elements using linear and/or rotational motion.

The present disclosure provides methods and systems for assaying a sample. A microfluidic device to perform an assay of a sample (e.g., biological sample) is described having a sample application site, a porous component and a flow channel. The porous component provides for uniform dissolution of a reagent and mixing of the sample and reagent without filtering the sample.

The present disclosure relates to a microfluidic device and a method allowing the generating and screening of combinatorial samples. A microfluidic device for producing droplets of at least one sample into an immiscible phase is provided, the device comprising a droplet maker connecting an immiscible phase channel and a sample channel having at least one sample inlet connected to at least one sample inlet channel injecting the at least one sample into the sample channel, wherein the injection of the at least one sample is controlled by at least one sample valve, so that the at least one sample flows either towards a sample waste outlet or into the at least one sample inlet channel, wherein different sample inlet channel of the at least one sample inlet channel have the same hydrodynamic resistance resulting from the length, height and width of each sample inlet channel upstream of the droplet maker.

The present invention relates broadly to microfluidic devices, particularly microfluidic devices optimised for the industrial production of nanoparticles such as liposomes. The device (101) comprises a substrate which extends between a distal end (107) comprising an outlet region (105) and a proximal end (108) comprising an inlet region (106). The inlet region comprises two substantially parallel outer channels (103a, 103b) for transport of a first fluid, said outer channels (103a, 103b) defined in part by a first outer wall (109a) and a second outer wall (109b) respectively, and a linear inner channel (104) for transport of a second fluid. The linear channel is disposed between the two substantially parallel outer channels. The outer channels (103a, 103b) and inner channel (104) extend from the proximal end (108) to a mixing chamber (102) which extends from the inlet region (106) to the outlet region (105). The mixing chamber (102) is in flow communication with the inner and outer channels (103a, 103b, 104) to receive the first and second fluids from the inner and outer channels (103a, 103b, 104) and the mixing chamber (102) has a uniform width (W) along its length substantially equal to the width (W1) between the outer walls (109a, 109b) of the two substantially parallel outer channels (103a, 103b).