Methods and systems for chromatography are disclosed that employ a flexible container configured to fit within a support structure and adapted to receive a filtration or absorptive medium, such as a chromatography resin. The flexible container can include at least one inlet, at least one outlet, and a separation barrier peripherally sealed within the container to separate the container into a resin containing portion and a drainage portion. The barrier can be configured to exclude the resin material from the drainage portion during use while allowing fluids to pass therethrough. The disposable chromatography system can further include one or more agitators disposed within the flexible container and adjustably configured to be raised or lowered in the flexible container. When the agitator is in the raised position, the resin packing material can operate in a settled, packed-bed configuration. Alternatively, the agitator in the lowered position permits the chromatography resin packing material to operate in a mixed, slurry configuration.

A method of mixing a pharmaceutical solution including adding a gas into an interior compartment of a mix bag to form a headspace. The interior compartment of the mix bag includes a top portion and a bottom portion. The headspace adjacent to the top portion contains gas. The method includes adding a solvent into the mix bag, and establishing a bubble column in the interior compartment by activating a recirculation assembly. The recirculation assembly includes a connecting pathway operably coupled to a recirculation pump. A first end of the connecting pathway is coupled to a top gas recirculation port and a second end is coupled to a bottom gas recirculation port of the mix bag such that the recirculation pump draws the gas from the headspace and delivers the gas to the interior compartment via the bottom gas recirculation port. The method includes adding a solute into the mix bag.

In a reaction apparatus, a reaction furnace is cylindrical and includes a supply port for receiving a raw material to be supplied at one end and a discharge port for discharging a reaction product at another end. A temperature control region includes an apparatus for controlling a temperature of the reaction furnace. A screw extends from the one end of the reaction furnace to the other end and is configured to be able to convey the raw material toward the discharge port by rotating. A first fluid control region includes a first fluid inlet and outlet for allowing a first fluid to pass through the reaction furnace in a predetermined region in the intermediate part. A second fluid control region includes a second fluid inlet and outlet for allowing a second fluid to pass through a region different from the first fluid control region in the intermediate part.

A system and an associated method for starting up stirring machines in a sediment in a controlled manner are provided, which system has the following: a container for receiving materials to be processed; a stirring device with stirring blades for stirring the materials to be processed in the container; a purging device; and a device for operating stirring machines. The purging device is arranged in such a way and set up so as to feed a medium for purging to a deposited sediment. Furthermore, a controller is provided which initiates controlled re-starting of stirring machines after purging.

The invention concerns an apparatus (1) for the dispersion of an expansion gas even in supercritical conditions, e.g. carbon dioxide, in a reactive resin, of the kind in which a reaction chamber having an input (27) for gas and an input (37) for resin is provided. Advantageously, the chamber is a dispersion and containment chamber made into a casing (2) of predetermined high resistance susceptible to sustain high pressure and is divided into two sections (6,7) by a head (14) of a dispersion and mixing cylinder-piston group (4) in fluid communication between themselves by means of at least one pouring passage (31, 36, 32, 39) provided with a static mixer (38), motor means (3) being provided for piston (34) control of said mixing cylinder-piston group (4). The invention also concerns a process for the formation of a polyurethane foam starting with the dispersion of carbon dioxide, even supercritical, in a reactive resin in which at least one initial dispersion and mixing controlled phase of the two components is provided in a dispersion and containment chamber under pressure divided into two sections (6,7) by a head (14) of a cylinder-piston mixing group (4) in fluid communication between themselves by means of at least one pouring passage (31, 36, 32, 39) provided with a static mixer (38) and in which adduction, dispersion and mixing occurs under high pressure (at least greater than 75 bar).

A rotor of a gas dispersion arrangement, including a cover disc, air slots arranged to protrude away from the cover disc, the air slots defining an interior space in the interior of the rotor, an air channel connected to the air slot for supplying air to be dispensed in slurry, and slurry slots arranged between and an alternating way with the air slots around the interior space. The slurry slots are in fluid communication with the interior space, and radially extending blades are arranged for separating the air slot from adjacent slurry slots. The cover disc includes at least one through-hole extending from an upper surface of the cover disc to at least one of the slurry slots.

An apparatus and methods of mixing materials in a silo that includes a mixing chamber (2) with an outlet (23) the bottom and an inlet hose (4) connected to an inlet opening at the top; a sieve (16) at the top of the mixing chamber above the inlet opening and below the outlet opening to prevent contact between a particulate mixing material and the top of the mixing chamber and to allow dust through; a pump system (18) to create a negative pressure region at the top of the mixing chamber; and an air manifold assembly (8), which includes an air pressure manifold (10) having an air nozzle (12) to introduce an air stream into the mixing chamber and an air manifold cover (14) to prevent contact between the particulate mixing material and the air pressure manifold, and to allow a particulate mixed product material to pass to the mixing chamber outlet.

A system for performing a gas-liquid mass transfer includes a container bounding a compartment and having a top wall, a bottom wall, and an encircling sidewall extending therebetween. A tube has a first end and an opposing second end, the first end of the tube being disposed within the compartment of the container. A nozzle is disposed within the compartment of the container and has at least one outlet, the nozzle being coupled with the tube so that a gas can be passed through the tube and out the at least one outlet of the nozzle. The nozzle is sufficiently buoyant so that when a fluid is disposed within the compartment of the container, the nozzle floats on the fluid.

A reactor for coating particles includes a stationary vacuum chamber that has a lower portion that forms a half-cylinder and an upper portion and that holds a bed of particles to be coated, a vacuum port in the upper portion of the chamber, a paddle assembly, and a gas injection assembly that includes a vaporizer to convert a first liquid to a first reactant or precursor gas, a manifold to receive the first reactant or precursor gas from the vaporizer, and a plurality of channels leading from the manifold to a plurality of apertures located in the lower portion of the chamber.

A system for performing a gas-liquid mass transfer includes a container bounding a compartment and having a top wall, a bottom wall, and an encircling sidewall extending therebetween. A first opening is formed on the container so as to communicate with the compartment. A liquid is disposed within the compartment and having a top surface disposed below the first opening. A gas is blown through the first opening so that the gas passes over at least a portion of the top surface of the liquid, the gas producing turbulence on the top surface of the liquid that is sufficient to produce a mass transfer between the gas and the liquid. A mixing element is disposed within the compartment.