The present disclosure is directed towards improved systems and methods for large-scale production of nanoparticles used for delivery of therapeutic material. The apparatus can be used to manufacture a wide array of nanoparticles containing therapeutic material including, but not limited to, lipid nanoparticles and polymer nanoparticles. In certain embodiments, continuous flow operation and parallelization of microfluidic mixers contribute to increased nanoparticle production volume.

According to the present invention, there is provided a foaming apparatus that discharges a foamable material obtained by mixing gas into a viscous material of a resin and dispersing bubbles in a liquid of the viscous material. The foaming apparatus includes: a pipe; a material supply unit; a gas supply unit; a first gear pump; a second gear pump; a third gear pump; a mixer; a discharge unit; and a control unit.

Provided is a carbon dioxide fluidity control device comprising, a sample preparation tank, a high-pressure stirring unit, a reciprocating plunger pump and a booster pump, wherein the stirring unit comprises one or more high-pressure stirring tanks, each provided with an atomizing spray probe and a piston, wherein a discharge port of the sample preparation tank is connected to the atomizing spray probe via a plunger pump, which is connected to the piston to push the piston to reciprocate; the booster pump is connected to the high-pressure stirring tanks to provide supercritical carbon dioxide to the high-pressure stirring tank; and a discharge port of the high-pressure stirring tanks is connected to an oilfield well group. Provided is a carbon dioxide fluidity control method using the device, comprising mixing surfactants and nanoparticles with heated carbon dioxide, and injecting a microemulsion of supercritical carbon dioxide and nano-silicon dioxide into an oilfield well group.

An automated apparatus for preparing a liquid bioprocess solution includes at least one mixing chamber having a lower port and an upper port for fluid to enter the at least one mixing chamber, an array of tubing for fluid flow within the system, a plurality of valves provided within the tubing, and a mixing controller configured to cause the automated apparatus to perform a series of sequential mixing steps causing the preparation of the liquid bioprocess solution from a dry ingredient. The series of sequential mixing steps include opening a first valve associated with the lower port to provide fluid to the at least one mixing chamber through the lower port, and after a predetermined amount of elapsed time, closing the first valve and opening a second valve associated with the upper port to provide fluid to the at least one mixing chamber through the upper port.

Mixer comprises a cabinet (1a) with upper lid (2a) and rear support (3) with fixed pulley (4) and drive motor (5), on whose axis the rotor (6a) is mounted. Rotor base (6a) receives a bearing (9) for turning of cup holder (7). Rotor disk (6a) has two side flaps for rollers (10) of the rotation belt (11a) of the cup holder (7) which has a shaft (12) and bearing (9) fastened on the rotor base (6a). Pulley (14) provokes the turning of cup holder (7) by way of the belt (11a). Cup holder (7) is a hollow cylinder with eccentric turning that cause strong agitation of the recipient with liquid. Turning movement of the cup holder (7) occurs on the two shafts which employ only one belt (11a). Mixer has two or four cup holders (7) and one or three tensioner rollers (16) on rotor base (6b) or (6c).

An insert assembly for a foam generating device includes a first insert and a second insert with a channel defined therethrough. Inserts may be formed by two shell halves that are coupleable to one another to define the channel. A plurality of ribs extends along an interior surface of the channel. Pad structures defined by porous media are provided in the channel and gripped by the plurality of ribs. The pads receive cleaning solution passing through the channel and cause foam to be generated by breaking-up the cleaning solution and agitating. The ribs may be arranged horizontally relative to a longitudinal axis of the insert assembly and retain the pads within the device. Inserts may be arranged in series along a longitudinal axis of the foam generating device with the pad structures arranged within the channel.

The present invention relates to a biological material extraction apparatus. According to the present invention, a tube in which a solution for use in extracting a biological material is contained is rotated to directly mix the solution, and cells where stirring is being conducted in each step are sealed to fundamentally block stirring-induced pollution between cells, thereby improving an extraction efficiency.

A can mixing device is disclosed. The device may include a base plate having a base plate proximal surface and a base plate distal surface. The device may further include a first rod having a first rod proximal end and a first rod distal end. The first rod distal end may be attached to a center portion of the base plate proximal surface. The device may further include a top plate having a first hole in a top plate center portion. The top plate may be configured to slide along a first rod length through the first hole. Further, the top plate may be attached to the first rod proximal end via a fastening member. Furthermore, the device may include a connection member attached to the base plate distal surface. The connection member may be configured to removably couple with a power tool configured to generate a device reciprocating movement.

An insert assembly for a foam generating device includes a first insert and a second insert with a channel defined therethrough. Inserts may be formed by two shell halves that are coupleable to one another to define the channel. A plurality of ribs extends along an interior surface of the channel. The channel is configured to grip porous pad structures by the plurality of ribs for generating form by breaking-up the cleaning solution and agitating. The ribs may be arranged horizontally relative to a longitudinal axis of the insert assembly. Inserts may be arranged in series along a longitudinal axis of the foam generating device.

A method for aerating a pasty product and for mixing with another product is disclosed herein. In one example, the method includes passing a stream of pasty product to be aerated through an apparatus. The apparatus includes a housing, the housing including an inlet for the pasty product to be aerated an outlet for the aerated product. The apparatus further includes a gas injector for injecting a gas into the pasty product to be aerated. The apparatus further includes an intermediate mixing chamber and a secondary product introduction member. The method further includes injecting via the upstream gas injector a gas into the pasty product stream at a position upstream relative to the first set of a rotor and a stator. The method further includes injecting a secondary product via the secondary product introduction member into the intermediate mixing chamber.