There is provided an apparatus and a method for producing a play compound and the play compound itself which, in one embodiment is a compound which sufficiently fluid to be pliable and is typically cold and slimy to the touch. The apparatus and a method provide a powder and liquid to a user, which can be a non-skilled person and thereby allow the mixing of the powder and liquid together by that person to form the play compound outside of a factory environment whilst ensuring that the play compound which is formed has the desired characteristics. Most typically the user which performs the mixing can be the end user, such as a child, who will play with the compound and so the formation of the play compound forms a new part of the play experience.

A beverage bottle includes a bottle body, a bottle lid and a cutting device, wherein the bottle body has a side wall and a bottle bottom disposed at the side wall, wherein the cutting device is provided at the bottle bottom of the bottle body.

An antibody-resin coupling apparatus quickly and efficiently activates resin beads and couples them to antibodies, while preventing breakdown and crosslinking of the beads, thereby improving downstream column purification processes, extending the usable life of the resin beads, and increasing molecule capture efficiency of the resultant resin-antibody complexes, to allow improved isolation and purification of factor VIII molecules or other drug compounds.

A blending machine, for homogenizing materials deposited within an intermediate bulk container (IBC), includes: a frame; a drive motor; a clamp disk rotatably supported by the frame and coupled to the drive motor to drive disk rotation; first and second jaw clamps movably mounted to the frame; and a drive mechanism to drive the jaw clamps to translate toward each other and rotatably secure the IBC's boom to the rotatable clamp disk. A clutch, a torque limiter, and a limit switch limit the pressure applied by the clamps, and the extent of their travel to optimize clamping and rotatability. The blending machine is moveably mounted to a pedestal, and elevated by an actuator. A blending bar within the IBC is coupled through the boom to the clamp disk, and driven to rotate to blend the materials, in addition to mixing by rotation of the ICB.

A mixing device, in particular bulk material mixing device, with at least one mixing container comprises a receiving region for receiving a material to be mixed, with at least one mixing unit which is configured for mixing the material to be mixed that is present in the mixing container, and with at least one lump breaker unit comprising at least one cutter element which protrudes into the mixing container, wherein the at least one lump breaker unit is arranged in a frontal region of the mixing container.

Mixing device having a container rotatable about container axis, with emptying opening being arranged in the bottom thereof, rotatable mixing tool arranged in the interior of the container, and closure element for closing the emptying opening. The closure element can be pivoted about a pivot axis for opening and closing the emptying opening. With the emptying opening closed, the closure element has inner surface arranged within the container, outer surface arranged outside the container, and edge surface arranged opposite an edge surface of the emptying opening. The closure element, emptying opening and pivot axis are of such a configuration and arrangement that a point arranged furthest away from the pivot axis on the inner surface or the edge surface describes a circle in the pivotal movement, wherein the closure element is arranged within the circle and the edge surfaces of the emptying opening are arranged outside the circle.

This disclosure relates to equipment utilized to manufacture chemical agents, particularly biopharmaceuticals. In some embodiments, reactor systems comprising a mobile carriage assembly; a disposable reaction container removably attached to the carriage assembly; and, a carriage holder into which the mobile carriage assembly may be removably inserted are provided.

A mixing machine for continuously mixing powder material in a liquid flow, including: a mixing section, a liquid inlet section located above the mixing section, and a powder inlet section located above the liquid inlet section and having a through-channel having a lower end communicating with the liquid inlet chamber and an upper end communicating with at least one powder inlet duct, wherein the powder inlet section comprises a valve having a valve member cooperating with a valve seat formed in the through-channel of the powder inlet section.

A mixing machine for continuously mixing powder material in a liquid flow, including a mixing body including: a mixing section in which a rotor is rotatably mounted, a liquid inlet section located above the mixing section, and a powder inlet section located above the liquid inlet section The powder inlet section is movable between a closed position and an open position, such that in the closed position the powder inlet section closes an upper edge of the liquid inlet section, and in the open position the powder inlet section is detached from the upper edge of the liquid inlet section.

There is provided an inline saturator system and method for gas exchange with an aqueous-phase liquid. The system includes a pressure vessel, configured to receive a first liquid and a first gas from external sources and to discharge a second liquid and a second gas from the pressure vessel, and a gas infusion device situated within the pressure vessel. The gas infusion device is configured to receive the first liquid and first gas, to facilitate gas exchange therebetween, producing the second liquid and the second gas, and to discharge the second liquid and second gas into the pressure vessel. The system further includes a recirculation system configured to direct a portion of liquid within the pressure vessel back into the saturator device, where injection of the redirected liquid into the gas infusion device forces the first liquid into the gas infusion device for the gas exchange.