A device for preparing a gelatin-based product having a mix tank, a mix pod that is fluidly coupled to the mix tank via a pod spike, and a hot water tank, where the hot water tank is coupled to the mix pod via the pod spike. In at least one example, the pod spike has an outer tube and an inner tube. In one or more examples, the pod spike of the device has a hub, where a first end of the outer tube is coupled to the hub. Further, in some examples, a first end of the inner tube may also be coupled to the hub.

A cylindrical or annular polymeric bioreactor is disclosed which provides enhanced mixing and aeration of the growth medium while simultaneously offering reduced mechanical shear force.

A bioreactor configured to contain a volume of liquid is provided. The bioreactor includes a collapsible bag able to contain the volume of liquid, a support structure surrounding and containing the collapsible bag, a first sparger connected to the collapsible bag, the first sparger having a first aperture size, and a second sparger connected to the collapsible bag, the second sparger having a second aperture size that is different from the first aperture size.

A reactor system includes a support housing having an interior surface bounding a chamber, the chamber having a vertically extending central longitudinal axis. A flexible bag is disposed within the chamber of the support housing and has an interior surface bounding a compartment. A mixing element is disposed within the compartment of the flexible bag. A drive element, such as a drive shaft, is secured the mixing element, wherein the mixing element is laterally offset from and/or is angled relative to the vertically extending central longitudinal axis of the support housing.

The present invention is directed to a fluid mixing system. In an embodiment, the fluid mixing system includes a first vessel; a second vessel disposed within the first vessel; a mixer disposed outside of the first vessel in fluid communication with the second vessel; and a media introduction port disposed outside of the first vessel in fluid communication with the mixer.

A bag assembly for use with a heat exchanger includes a flexible bag having of one or more sheets of polymeric material, the bag having a first end that bounds a first compartment and an opposing second end that bounds a second compartment, a support structure being disposed between the first compartment and the second compartment so that the first compartment is separated and isolated from the second compartment. A first inlet port, a first outlet port, and a first drain port are coupled with the flexible bag so as to communicate with the first compartment. A second inlet port, a second outlet port, and a second drain port are coupled with the flexible bag so as to communicate with the second compartment.

Miniature stirred tank bioreactor and system; the bioreactor configured for single use culturing providing unobstructed culturing volume with sensors, probes and ports using minimally invasive placement in-wall or across the wall methods; the bioreactor further capable of containing scaffolds and features for culturing cells and tissue, including structures providing surfaces for cell growth, and screens for retaining microparticles during media exchange.

A disposable material processing apparatus, useable as a bioreactor or fermenter, includes a hollow tank (101) and a mixing paddle (110) disposed within the interior of the tank and adapted to mix contents therein. The paddle may be isolated within a flexible sleeve (140). Various functional elements, such as a sparger, sensor, material extraction conduit, material addition conduit, and/or heat exchange element may be provided, and optionally arranged to travel with the paddle within the tank interior. Baffles may protrude into a mixing tank to enhance mixing. A tank and/or sleeve may comprise polymeric film materials.

A container having a recess or a series of projections on the interior side of its wall to catch or restrain a magnetic stir bar during the pouring of contents from the container. The recess or series of projections may extend along the full interior circumference of the container or may be vertically aligned with a spout located at the opening of the container. One or more drainage channels extending from the recess towards the opening of the container may be provided to assist in pouring the contents out of the container.

In order to provide a feed mixture, a feed mixer is proposed which has a container. The container has a bottom and a wall which is connected to the bottom and delimits a filling opening, the area of which is greater than the area of the bottom. A rotatable auger is provided which can be rotated about an axis, the axis running substantially perpendicularly with respect to the bottom. The feed mixer has a pivoting device which is intended and suitable for pivoting the container during a mixing operation, in particular after a predefined time period or after a predefined number of revolutions of the at least one auger.