Provided is an ultra-fine bubble generator capable of efficiently generating ultra-fine bubbles in fluid. The generator is a fluid activating device including: a shaft in a cylindrical columnar shape; a tubular body provided with a hollow part to accommodate the shaft with a predetermined interval between an inner peripheral surface of the hollow part and an outer peripheral surface of the shaft; and multiple blades that are provided between the outer peripheral surface of the shaft and an inner peripheral surface of the tubular body while forming a flow path extending spirally from one end of the tubular body toward another end of the tubular body, and that generate a turbulent flow in fluid flowing in the flow path, the tubular body having an inner peripheral surface provided with multiple ribs each composed of a ridge extending in an axial direction of the shaft.

A jet impingement reactor having a housing made of a polymeric material, including at least two housing pieces that are affixed to one another. The housing encloses a substantially spherical reaction chamber having at least two fluid inlets provided by nozzles and a fluid outlet. Further provided are methods for making the reactor based on injection molding, as well as the use of the reactor for the aseptic manufacture of a sterile liquid pharmaceutical compositions, in particular compositions including nanoparticles such as lipid nanoparticles.

A mixer insert for a static mixer, includes mixing elements that are arranged behind one another along a longitudinal central axis. The mixing elements have a web arrangement including a plurality of intersecting or mutually adjoining webs. The mixing elements have web arrangements that are rotated by an angle of rotation with respect to one another. The mixer insert is configured as a single-part component.

A microdroplet/bubble-generating device comprising a slit and a row of a plurality of microflow paths is constructed, in such a manner that either a continuous phase or dispersion phase is supplied to the slit, and so that the end of the slit, the other supply port for the continuous phase or dispersion phase and the liquid recovery port are connected. The plurality of microflow paths each have a narrow part where the cross-sectional area of the flow channel is locally narrowed adjacent to or near the connection point between the slit and the microflow path. The continuous phase and dispersion phase that have met at the connection points flow into the narrow parts, and the dispersion phase is sheared at the narrow parts with the continuous phase flow as the driving force, forming droplets or gas bubbles of the dispersion phase. The product is recovered from the liquid recovery port.

A compound preparation system for infusing, melting, activating, or blending botanical, fungal, or carrier formulations using indirect heat, programmable mixing, and compound-specific logic. The system integrates a removable canister, sensor-driven thermal control, modular agitation, and a processor executing workflows based on the ELOH (Empirical Logic Organizing Heuristics) database. The system enables users to optimize compound yield, flavor, scent, or potency through guided prompts, real-time estimation, and synergy-aware enhancements.