The present invention relates to means for manufacturing micro-beads (polymer micro-particles) comprising thermoplastic polymer and having the average particle size of 10 μm or less, and extending into the nano-range. An original filament comprising a thermoplastic polymer is passed through an orifice under an air pressure (P1) and guided to a spray chamber under a pressure (P2; where P1>P2). The original filament having passed through the orifice is heated and melted under irradiation by an infrared beam, and is sprayed in microparticulate form from the orifice by the flow of air generated by the pressure differential between P1 to P2, whereby micro-beads comprising thermoplastic polymer micro-particles having an average particle size of 10 μm or less, and even less than 1 μm are manufactured.

The present invention relates to means for manufacturing micro-beads (polymer micro-particles) comprising thermoplastic polymer and having the average particle size of 10 μm or less, and extending into the nano-range. An original filament comprising a thermoplastic polymer is passed through an orifice under an air pressure (P1) and guided to a spray chamber under a pressure (P2; where P1>P2). The original filament having passed through the orifice is heated and melted under irradiation by an infrared beam, and is sprayed in microparticulate form from the orifice by the flow of air generated by the pressure differential between P1 to P2, whereby micro-beads comprising thermoplastic polymer micro-particles having an average particle size of 10 μm or less, and even less than 1 μm are manufactured.

A method and system for coating metallic powder particles is provided. The method includes: disposing an amount of metallic powder particulates within a fluidizing reactor; removing moisture adhered to the powder particles disposed within the reactor using a working gas; coating the powder particles disposed within the reactor using a precursor gas; and purging the precursor gas from the reactor using the working gas.

A method and system for coating metallic powder particles is provided. The method includes: disposing an amount of metallic powder particulates within a fluidizing reactor; removing moisture adhered to the powder particles disposed within the reactor using a working gas; coating the powder particles disposed within the reactor using a precursor gas; and purging the precursor gas from the reactor using the working gas.

An injector head for delivering particulate material from a feeder source to a receiver is fitted with a plurality of splitter bars extending generally laterally from the sidewalls thereof into the space through which particulate material is fed as it flows into a receiver. Spray nozzles mounted to said sidewalls below said splitter bars spray coating material generally laterally relative to said sidewalls and generally laterally relative to the length of said splitter bars so as to coat particulate material as it passes over and to the sides and ends of said splitter bars.

Compositions are provided that include having at least 95% by weight of a taxane, or a pharmaceutically acceptable salt thereof, where the particles have a mean bulk density between about 0.050 g/cm.sup.3 and about 0.15 g/cm.sup.3, and/or a specific surface area (SSA) of at least 18 m.sup.2/g, 20 m.sup.2/g, 25 m.sup.2/g, 30 m.sup.2/g, 32 m.sup.2/g, 34 m.sup.2/g, or 35 m.sup.2/g. Methods for making and using such compositions are also provided.

The process comprises delivering a spray solution comprising an active agent and a matrix material in an organic solvent to a spray-drying apparatus, atomizing the spray solution into droplets within the spray-drying apparatus to remove at least a portion of the organic solvent from the droplets to form a plurality of particles, and collecting the particles. The spray solution may be formed by forming a feed suspension comprising the active agent, the matrix material, and the organic solvent, wherein the feed suspension is at a temperature T.sub.1, and directing the feed suspension to a heat exchanger, thereby increasing the temperature of the feed suspension to a temperature T.sub.2, wherein T.sub.2 is greater than T.sub.1, and the spray solution is at a pressure greater than the vapor pressure of the organic solvent at T.sub.2, such that the active agent and matrix material are soluble in the organic solvent at T.sub.2.

The process comprises delivering a spray solution comprising an active agent and a matrix material in an organic solvent to a spray-drying apparatus, atomizing the spray solution into droplets within the spray-drying apparatus to remove at least a portion of the organic solvent from the droplets to form a plurality of particles, and collecting the particles. The spray solution may be formed by forming a feed suspension comprising the active agent, the matrix material, and the organic solvent, wherein the feed suspension is at a temperature T.sub.1, and directing the feed suspension to a heat exchanger, thereby increasing the temperature of the feed suspension to a temperature T.sub.2, wherein T.sub.2 is greater than T.sub.1, and the spray solution is at a pressure greater than the vapor pressure of the organic solvent at T.sub.2, such that the active agent and matrix material are soluble in the organic solvent at T.sub.2.

The present invention provides, inter alia, for a liquid feeding device for the generation of droplets, in particular for the use in a process line for the production of freeze-dried particles, with a droplet ejection section for ejecting liquid droplets in an ejection direction, the droplet ejection section comprising at least one inlet port for receiving a liquid to be ejected, a liquid chamber for retaining the liquid, and a nozzle for ejecting the liquid from the liquid chamber to form droplets, wherein the liquid chamber is restricted by a membrane on one side thereof, the membrane being vibratable by an excitation unit, wherein the longitudinal axis of the liquid chamber is tilted relative to the longitudinal axis of the nozzle, and/or the liquid feeding device further comprises a deflection section for separating the droplets from each other by means of at least one gas jet, wherein the deflection section gas jet intersects perpendicular with an ejection path of the liquid ejected from the liquid chamber.

The present invention provides, inter alia, for a liquid feeding device for the generation of droplets, in particular for the use in a process line for the production of freeze-dried particles, with a droplet ejection section for ejecting liquid droplets in an ejection direction, the droplet ejection section comprising at least one inlet port for receiving a liquid to be ejected, a liquid chamber for retaining the liquid, and a nozzle for ejecting the liquid from the liquid chamber to form droplets, wherein the liquid chamber is restricted by a membrane on one side thereof, the membrane being vibratable by an excitation unit, wherein the longitudinal axis of the liquid chamber is tilted relative to the longitudinal axis of the nozzle, and/or the liquid feeding device further comprises a deflection section for separating the droplets from each other by means of at least one gas jet, wherein the deflection section gas jet intersects perpendicular with an ejection path of the liquid ejected from the liquid chamber.