A system and method for producing fine droplets of polysaccharide from a premixed water-in-oil emulsion uses a packed bed (5) comprising hydrophilic beads (7).

A first fluid is dispersed in a second fluid to form an emulsion of micro-droplets having an average droplet size and having a droplet size distribution around said average droplet size and below a maximum droplet size. Said micro-droplets will lose their solvent to transform to micro-spheres exhibiting a particle size distribution around an average particle size and substantially below a maximum allowable particle size. Said micro-spheres are subjected to a micro-filter having a relatively narrow pore size distribution around an average pore size, which average pore size is between said average particle size and said maximum particle size. A filtrate of said micro-filter comprises a majority of said micro-spheres that is substantially void of micro-spheres having a particle size exceeding the maximum allowable particle size.

A porous acoustic bead resonator is provided, wherein the Young's modulus of the material of the resonator is lower than 1 GPa and the porosity of the resonator is comprised between 20% and 50%, most of the pores of the resonator being filled with a gas and most of the pores being interconnected, via at least one pore, with the exterior of the resonator.

A porous acoustic bead resonator is provided, wherein the Young's modulus of the material of the resonator is lower than 1 GPa and the porosity of the resonator is comprised between 20% and 50%, most of the pores of the resonator being filled with a gas and most of the pores being interconnected, via at least one pore, with the exterior of the resonator.

Provided is an apparatus for producing solid polymeric microparticles, the apparatus comprising a plurality of liquid droplet generators for forming liquid droplets of a first liquid, and a nozzle for forming a jet of a second liquid, wherein the plurality of liquid droplet generators and the nozzle are arranged relative to each other such that, in use, liquid droplets from the plurality of liquid droplet generators pass through a gas into said jet of second liquid. Also provided is a process for producing solid microparticles, the process comprising: providing a first liquid comprising a solute and a solvent, the solute comprising a biocompatible polymer, the concentration of polymer in the first liquid being at least 10% w/v, ‘w’ being the weight of the polymer and ‘v’ being the volume of the solvent, providing a plurality of liquid droplet generators operable to generate liquid droplets, providing a jet of a second liquid, causing the plurality of liquid droplet generators to form liquid droplets of the first liquid, passing the liquid droplets through a gas to contact the jet of the second liquid so as to cause the solvent to exit the droplets, thus forming solid microparticles, the solubility of the solvent in the second liquid being at least 5 g of solvent per 100 ml of second liquid, the solvent being substantially miscible with the second liquid.

Device for producing pulverulent plastics with a spherical structure comprises: a container delimiting an interior space, a nozzle device disposed in an upper region of the interior space and connected to a supplying conveyor pipe for a hot melt of the product, wherein the melt exits the nozzle device and separates into small droplets that fall downward in the interior space, a supply unit for a cryogas in a predominantly liquid state having several outlet openings, wherein a cryogas flow, which comes into contact with the small droplets, exits into the interior space. The supply unit is located above or at the same level as the nozzle device, and method wherein, the hot melt of the product exits the nozzle device in the shape of a spray cone, the cryogas flow exits the supply unit in the shape of a cone, and the spray cone is located within the cone.

Device for producing pulverulent plastics with a spherical structure comprises: a container delimiting an interior space, a nozzle device disposed in an upper region of the interior space and connected to a supplying conveyor pipe for a hot melt of the product, wherein the melt exits the nozzle device and separates into small droplets that fall downward in the interior space, a supply unit for a cryogas in a predominantly liquid state having several outlet openings, wherein a cryogas flow, which comes into contact with the small droplets, exits into the interior space. The supply unit is located above or at the same level as the nozzle device, and method wherein, the hot melt of the product exits the nozzle device in the shape of a spray cone, the cryogas flow exits the supply unit in the shape of a cone, and the spray cone is located within the cone.

A spray drying process and apparatus for drying a spray dryable liquid composition to a spray dried powder is described, in which the spray dryable liquid composition contains no carrier. The spray dryable liquid composition is processed at a solids concentration not exceeding 80% by weight, based on total weight of the spray dryable liquid composition, being atomized to generate an atomized spray of liquid particles of the spray dryable liquid composition into a spray drying chamber, in which the atomized spray is contacted with a stream of drying fluid flowed at temperature not exceeding 100° C. into the spray drying chamber, to form the spray dried powder.

A spray drying process and apparatus for drying a spray dryable liquid composition to a spray dried powder is described, in which the spray dryable liquid composition contains no carrier. The spray dryable liquid composition is processed at a solids concentration not exceeding 80% by weight, based on total weight of the spray dryable liquid composition, being atomized to generate an atomized spray of liquid particles of the spray dryable liquid composition into a spray drying chamber, in which the atomized spray is contacted with a stream of drying fluid flowed at temperature not exceeding 100° C. into the spray drying chamber, to form the spray dried powder.

Provided is an organic solvent-free method for producing a plurality of microsphere having an average diameter of less than 500 μm in diameter and having average contact angle θc greater than 140°, consisting essentially of a biocompatible hot-melt carrier vehicle and a payload substance to be delivered, including melting and mixing a polymer carrier vehicle which is solid at room temperature and at least one payload substance, and dispensing microportions of the molten mixture through a droplet-forming space onto a cooled solid superoleophobic surface.