Atomization processes for manufacturing a metal powder or an alloy powder having a melting point comprising of about 50 Celsius to about 500 Celsius are provided herein. In at least one embodiment, the processes comprise providing a melt of a metal or an alloy having said melting point of about 50 Celsius to about 500 Celsius through a feed tube; diverting the melt at a diverting angle with respect to a central axis of the feed tube to obtain a diverted melt; directing the diverted melt to an atomization area; and providing at least one atomization gas stream to the atomization area. The atomization process can be carried out in the presence of water within an atomization chamber used for the atomization process. In at least one embodiment, the processes provide a distribution of powder with an average particle diameter under 20 microns with geometric standard deviation of lower than about 2.0.

Atomization processes for manufacturing a metal powder or an alloy powder having a melting point comprising of about 50 Celsius to about 500 Celsius are provided herein. In at least one embodiment, the processes comprise providing a melt of a metal or an alloy having said melting point of about 50 Celsius to about 500 Celsius through a feed tube; diverting the melt at a diverting angle with respect to a central axis of the feed tube to obtain a diverted melt; directing the diverted melt to an atomization area; and providing at least one atomization gas stream to the atomization area. The atomization process can be carried out in the presence of water within an atomization chamber used for the atomization process. In at least one embodiment, the processes provide a distribution of powder with an average particle diameter under 20 microns with geometric standard deviation of lower than about 2.0.

A method for obtaining at least one particle, including: (a) preparing solution A including at least one precursor of at least one of Si, B, P, Ge, As, Al, Fe, Ti, Zr, Ni, Zn, Ca, Na, Ba, K, Mg, Pb, Ag, V, Te, Mn, Ir, Sc, Nb, Sn, Ce, Be, Ta, S, Se, N, F, and Cl; (b) preparing aqueous solution B; (c) forming droplets of solution A; (d) forming droplets of solution B; (e) mixing droplets; (f) dispersing mixed droplets in a gas flow; (g) heating dispersed droplets to obtain the at least one particle; (h) cooling the at least one particle; and (i) separating and collecting the at least one particle. The aqueous solution is acidic, neutral, or basic. In step (a) and/or step (b) at least one colloidal suspension of a plurality of nanoparticles is mixed with the solution. Also, a device for implementing the method.

A method and an apparatus for a large-scale production of monodisperse microspheres and biodegradable polymer-based drug delivery systems and design optimization method for the apparatus are provided. The method uses a plurality of microchips, each microchip having at least a first pathway, a second pathway and an outlet, wherein the first pathway and the second pathway merge at a cross point being one end of the outlet, and the method comprises preparing a polymer-phase solution including a degradable polymer and a water-phase solution including a surfactant, having the polymer-phase solution flow through the first pathway, having the water-phase solution flow through the second pathway, gathering a mixed solution flowing out of the outlet, and collecting the microspheres by filtering out the water-phase solution.

A method and an apparatus for a large-scale production of monodisperse microspheres and biodegradable polymer-based drug delivery systems and design optimization method for the apparatus are provided. The method uses a plurality of microchips, each microchip having at least a first pathway, a second pathway and an outlet, wherein the first pathway and the second pathway merge at a cross point being one end of the outlet, and the method comprises preparing a polymer-phase solution including a degradable polymer and a water-phase solution including a surfactant, having the polymer-phase solution flow through the first pathway, having the water-phase solution flow through the second pathway, gathering a mixed solution flowing out of the outlet, and collecting the microspheres by filtering out the water-phase solution.

A device for spherification of a liquid includes a first device for storing a first liquid; and a spherification tank for storing a second liquid, arranged so that the second liquid defines a level of the second liquid in the spherification tank. A device meters the first liquid coming from the first tank into the spherification tank. An extraction device extracts spheres generated in the spherification tank as a result of the metering. The extraction device includes a worm screw located in the spherification tank, the worm screw being arranged at an angle to the level, and a motor for rotating the worm screw.

A device for spherification of a liquid includes a first device for storing a first liquid; and a spherification tank for storing a second liquid, arranged so that the second liquid defines a level of the second liquid in the spherification tank. A device meters the first liquid coming from the first tank into the spherification tank. An extraction device extracts spheres generated in the spherification tank as a result of the metering. The extraction device includes a worm screw located in the spherification tank, the worm screw being arranged at an angle to the level, and a motor for rotating the worm screw.

Cryogranulation systems with improved dispenser assemblies are provided for use in manufacturing frozen pellets of pharmaceutical substances in a fluid medium. Methods of cryogranulating the pharmaceutical substance in the fluid medium are also provided. In particular embodiments, the dispenser assembly is used with suspensions or slurries of pharmaceutical compositions including biodegradable substances, such as proteins, peptides, and nucleic acids. In certain embodiments, the pharmaceutical substance can be adsorbed to any pharmaceutically acceptable carrier particles suitable for making pharmaceutical powders. In one embodiment, the pharmaceutical carrier can be, for example, diketopiperazine-based microparticles. The dispenser assembly improves the physical characteristics of the cryopellets formed and minimizes product loss during processing.

Cryogranulation systems with improved dispenser assemblies are provided for use in manufacturing frozen pellets of pharmaceutical substances in a fluid medium. Methods of cryogranulating the pharmaceutical substance in the fluid medium are also provided. In particular embodiments, the dispenser assembly is used with suspensions or slurries of pharmaceutical compositions including biodegradable substances, such as proteins, peptides, and nucleic acids. In certain embodiments, the pharmaceutical substance can be adsorbed to any pharmaceutically acceptable carrier particles suitable for making pharmaceutical powders. In one embodiment, the pharmaceutical carrier can be, for example, diketopiperazine-based microparticles. The dispenser assembly improves the physical characteristics of the cryopellets formed and minimizes product loss during processing.

The present disclosure provides a system and method for granulating and molding silicon liquid. The system includes a silicon liquid transferring device, wherein cooling system and a lifting system matching with the cooling system are provided below the silicon liquid transferring device. The silicon liquid transferring device transfers smelted silicon liquid to a position above the cooling system, uniformly pours the silicon liquid into the cooling system according a set flow to enable the silicon liquid to be solidified into silicon pellets, and then the molded silicon pellets are extracted by the lifting system, solving the problem in the prior art of irregular molding and inconsistent size of silicon blocks caused by pouring. A container bottom and a diversion pipe are set to be of detachable structures, and can be quickly disassembled and assembled as vulnerable parts without affecting the production.