Biocompatible intraocular implants, such as microparticles, include a prostamide component and a biodegradable polymer that is effective in facilitating release of the prostamide component into an eye for an extended period of time. The prostamide component may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the prostamide component may be encapsulated by the polymeric component. The present implants include oil-in-oil emulsified implants or microparticles. Methods of producing the present implants are also described. The implants may be placed in an eye to treat or reduce a at least one symptom of an ocular condition, such as glaucoma.

The present disclosure discloses a method of preparing a carbon-coated ceria hollow sphere, which includes the following steps of: S110, dispersing silica in a solvent to obtain a silica dispersion; S120, performing a hydrothermal reaction between the silica dispersion and a cerium salt to obtain a ceria-coated silica microsphere; S140, coating the ceria-coated silica microsphere with a carbon source to obtain a primary product, wherein the carbon source is dopamine; S160, sintering the primary product under a protective gas atmosphere to obtain a carbon-coated ceria microsphere; and S170, etching the carbon-coated ceria microsphere by using an etchant to obtain a carbon-coated ceria hollow sphere.

The present disclosure discloses a method of preparing a carbon-coated ceria hollow sphere, which includes the following steps of: S110, dispersing silica in a solvent to obtain a silica dispersion; S120, performing a hydrothermal reaction between the silica dispersion and a cerium salt to obtain a ceria-coated silica microsphere; S140, coating the ceria-coated silica microsphere with a carbon source to obtain a primary product, wherein the carbon source is dopamine; S160, sintering the primary product under a protective gas atmosphere to obtain a carbon-coated ceria microsphere; and S170, etching the carbon-coated ceria microsphere by using an etchant to obtain a carbon-coated ceria hollow sphere.

The invention relates to a process for the manufacture of thermally expandable thermoplastic microspheres. The process comprises, providing a mixture of monomeric materials suitable for polymerisation to form a thermoplastic polymer and at least one blowing agent, providing to the mixture a colloidal silica that is surface-modified with at least hydrophobic organosilane groups and forming an emulsion. A polymerisation is performed to form the thermally expandable thermoplastic microspheres. The invention further relates to thermally expandable thermoplastic micro spheres, expanded micro spheres and their use in the manufacture of products.

The invention relates to a process for the manufacture of thermally expandable thermoplastic microspheres. The process comprises, providing a mixture of monomeric materials suitable for polymerisation to form a thermoplastic polymer and at least one blowing agent, providing to the mixture a colloidal silica that is surface-modified with at least hydrophobic organosilane groups and forming an emulsion. A polymerisation is performed to form the thermally expandable thermoplastic microspheres. The invention further relates to thermally expandable thermoplastic micro spheres, expanded micro spheres and their use in the manufacture of products.

Structures of a particle containing a core and at least one shell, a metal oxide material of which is necessarily doped to ensure protection of a material of the core from photodegradation. The core can include any of a thermochromic material, a phase-change material, and a judiciously defined auxiliary material that in turn contains organic and/or polymeric material. Derivative products utilizing a plurality of such particles. Methodologies for producing such particles and derivative products.

Structures of a particle containing a core and at least one shell, a metal oxide material of which is necessarily doped to ensure protection of a material of the core from photodegradation. The core can include any of a thermochromic material, a phase-change material, and a judiciously defined auxiliary material that in turn contains organic and/or polymeric material. Derivative products utilizing a plurality of such particles. Methodologies for producing such particles and derivative products.

A population of capsules, the capsules can include a core including a benefit agent and a shell surrounding the core, wherein the shell can include a first shell component.

A population of capsules, the capsules can include a core including a benefit agent and a shell surrounding the core, wherein the shell can include a first shell component.

There is provided a composite comprising an inorganic metal or alloy core at least partially covered by a protection layer comprising a carboxylate salt, a metal oxide, a metal oxide salt or a metal-amino acid complex. There is also provided a method of preparing the composite comprising an inorganic metal or alloy core at least partially covered by a protection layer comprising a carboxylate salt, a metal oxide, a metal oxide salt or a metal-amino acid complex, comprising the step of mixing a metal or alloy with an acid, at elevated temperature for a time duration, optionally in the presence of a solvent. There is also provided use of a composite as an antimicrobial agent, and uses of a composite in the treatment or prophylaxis of microbial infection. There is also provided a method of inhibiting microbial activity or treating a microbial infection or disease comprising administering an antimicrobial composition comprising said composite as disclosed herein to a subject or applying the antimicrobial composition on a surface.