The invention provides a process for preparing core-shell composite particles comprising a polyester, polymerized ethylenically unsaturated silane compounds, and optionally a hydrophobic surface treatment. The invention further provides a composite particle comprising a polyester and a radically polymerized ethylenically unsaturated silane compound.

The present invention is an ethyl vanillin and/or vanillin friable shell-core microcapsule composition prepared by combining ethyl vanillin or vanillin with preformed friable shell-core microcapsules for a time sufficient for the ethyl vanillin or vanillin and microencapsulates to interact. Wash off consumer products and a method for depositing ethyl vanillin or vanillin on a surface are also provided.

Described herein is solid scent booster composition including: solid carrier, granulated powder including particles made of: a) a water soluble polymer matrix, b) an oil phase including a perfume dispersed in the polymer matrix, the oil being at least partly encapsulated in microcapsules, wherein granulated powder includes up to 30% by weight of encapsulated oil based on the total weight of the powder.

A method of manufacturing a triple capsule includes supplying an interior material, an intermediate film material, and an exterior film material; discharging a triple molding body by receiving the interior material, the intermediate film material, and the exterior film material through a nozzle mount and performing coextrusion on the interior material, the intermediate film material, and the exterior film material through a triple nozzle in which a first nozzle discharging the interior material, a second nozzle discharging the intermediate film material, and a third nozzle discharging the exterior film material are arranged concentrically; and forming the triple capsule by circulating a coolant and cooling the triple molding body.

The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing a suspension of preformed lipid nanoparticles and mRNA.

A system and method are directed toward the synthesis of polymeric capsules using a phase inversion process by extrusion of polymeric droplets through a syringe-needle assembly or an iris-shutter mechanism. The polymeric solution may be prepared by dissolving PAN (polyacrylonitrile) polymer in DMF (Dimethyl Formamide) solvent at high temperature through continuous stirring. Following preparation of the capsules, further treatment was initiated using triethylamine in gelation bath to make the final product an efficient removal agent of water hardness.

A system and method are directed toward the synthesis of polymeric capsules using a phase inversion process by extrusion of polymeric droplets through a syringe-needle assembly or an iris-shutter mechanism. The polymeric solution may be prepared by dissolving PAN (polyacrylonitrile) polymer in DMF (Dimethyl Formamide) solvent at high temperature through continuous stirring. Following preparation of the capsules, further treatment was initiated using triethylamine in gelation bath to make the final product an efficient removal agent of water hardness.

An extracellular vesicle separation method, a colloidal particle, and a preparation method thereof are provided. The colloidal particle is used for extracellular vesicle separation, and includes 2 wt % to 6 wt % of agarose. The colloidal particle has a particle size of 25 μm to 500 μm, and is surface-modified with biocompatible molecules. The biocompatible molecules include sodium carboxymethyl cellulose (CMC), methyl cellulose (MC), glycine, aspartic acid, glutamic acid, bovine serum albumin (BSA), fetal bovine serum (FBS), or a combination thereof.

An extracellular vesicle separation method, a colloidal particle, and a preparation method thereof are provided. The colloidal particle is used for extracellular vesicle separation, and includes 2 wt % to 6 wt % of agarose. The colloidal particle has a particle size of 25 μm to 500 μm, and is surface-modified with biocompatible molecules. The biocompatible molecules include sodium carboxymethyl cellulose (CMC), methyl cellulose (MC), glycine, aspartic acid, glutamic acid, bovine serum albumin (BSA), fetal bovine serum (FBS), or a combination thereof.

A device includes a heating zone having an inlet, and an outlet, a pump upstream of and in fluid communication with the heating zone, and capable of generating above-atmospheric pressure in the heating zone; an element for heating the heating zone; an expansion zone with an inlet and an outlet, said inlet of the expansion zone being connected to the outlet of the heating zone in such a way that a pressure drop is created, such that the expansion zone is at a lower pressure than the heating zone; and a back pressure generator downstream of the expansion zone configured to create a variable counter pressure in the expansion zone.