The present application provides processes for preparing 4-[3-(cyanomethyl)-3-(3′,5′-dimethyl-1H, 1′H-4,4′-bipyrazol-1-yl)azetidin-1-yl]-2,5-difluoro-N-[(1S)-2,2,2-trifluoro-1-methylethyl]benzamide, and phosphoric acid salt thereof, which is useful as a selective (Janus kinase 1) JAK1 inhibitor, as well as salt forms and intermediates related thereto.

Provided is a catalyst that has excellent oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) catalytic activity and is useful as a catalyst for water electrolysis, an electrode catalyst for an air battery, or the like. The catalyst includes (A) either or both of Ni atoms and Fe atoms, (B) thiourea, and (C) fibrous carbon nanostructures. It is preferable that the catalyst includes (A) Ni atoms and Fe atoms, that the thiourea is coordinated with the Ni atoms and the Fe atoms, and that a mass ratio of the content of a Ni-thiourea coordination compound relative to the content of an Fe-thiourea coordination compound (Ni-thiourea coordination compound/Fe-thiourea coordination compound) is not less than 5/95 and not more than 70/30.

A platinum-catalyzed composition along with a process for producing the same and a shaped body or products made from the same. The platinum-catalyzed composition is crosslinkable by a hydrosilylation reaction. The composition includes strong acids (S) having a pKa of <2.5 is less than 0.3 ppm by weight The platinum catalysts are those having the formula R.sup.1.sub.3Pt{CpR.sup.2.sub.5} wherein Cp is the cyclopentadienyl radical and R.sup.1 may be identical or different and is a monovalent, optionally substituted, aliphatically saturated hydrocarbon radical. R.sup.2 may be identical or different and is a hydrogen atom, SiC-bonded silyl radical or a monovalent, optionally substituted hydrocarbon radical.

A platinum-catalyzed composition along with a process for producing the same and a shaped body or products made from the same. The platinum-catalyzed composition is crosslinkable by a hydrosilylation reaction. The composition includes strong acids (S) having a pKa of <2.5 is less than 0.3 ppm by weight The platinum catalysts are those having the formula R.sup.1.sub.3Pt{CpR.sup.2.sub.5} wherein Cp is the cyclopentadienyl radical and R.sup.1 may be identical or different and is a monovalent, optionally substituted, aliphatically saturated hydrocarbon radical. R.sup.2 may be identical or different and is a hydrogen atom, SiC-bonded silyl radical or a monovalent, optionally substituted hydrocarbon radical.

Disclosed is an application of a hydrophobic phthalocyanine as a heterogeneous catalyst in oxidizing phenol wastewater by hydrogen peroxide. A hydrophobic silane is decorated on a bacterial cellulose-metal phthalocyanine heterogeneous catalyst to obtain a hydrophobic phthalocyanine heterogeneous catalyst; during the catalytic degradation of phenols, the obtained catalyst is capable of adjusting a concentration of hydrogen peroxide oxidant around the catalyst. A preparation method of the hydrophobic phthalocyanine comprises: 1. preparing a mixed solution of a bacterial cellulose medium containing metal phthalocyanine; 2. adding acetic acid bacterium into the mixed solution obtained in step 1 for biological culture; 3. heating the product obtained in step 2, and taking out a solid for cleaning and drying; 4. preparing a hydrophobic silane solution; and 5. immersing the product obtained in step 3 into the solution obtained in step 4, and taking out a solid after reaction for cleaning and drying.

Disclosed is an application of a hydrophobic phthalocyanine as a heterogeneous catalyst in oxidizing phenol wastewater by hydrogen peroxide. A hydrophobic silane is decorated on a bacterial cellulose-metal phthalocyanine heterogeneous catalyst to obtain a hydrophobic phthalocyanine heterogeneous catalyst; during the catalytic degradation of phenols, the obtained catalyst is capable of adjusting a concentration of hydrogen peroxide oxidant around the catalyst. A preparation method of the hydrophobic phthalocyanine comprises: 1. preparing a mixed solution of a bacterial cellulose medium containing metal phthalocyanine; 2. adding acetic acid bacterium into the mixed solution obtained in step 1 for biological culture; 3. heating the product obtained in step 2, and taking out a solid for cleaning and drying; 4. preparing a hydrophobic silane solution; and 5. immersing the product obtained in step 3 into the solution obtained in step 4, and taking out a solid after reaction for cleaning and drying.

This invention provides supported catalysts comprising a carrier, phosphorus, at least one Group VI metal, at least one Group VIII metal, and a polymer. In the catalyst, the molar ratio of phosphorus to Group VI metal is about 1:1.5 to less than about 1:12, the molar ratio of the Group VI metal to the Group VIII metal is about 1:1 to about 5:1, and the polymer has a carbon backbone and comprises functional groups having at least one heteroatom. Also provided are a process for preparing such supported catalysts, as well as methods for hydrotreating, hydrodenitrogenation, and/or hydrodesulfurization, using supported catalysts.

This invention provides supported catalysts comprising a carrier, phosphorus, at least one Group VI metal, at least one Group VIII metal, and a polymer. In the catalyst, the molar ratio of phosphorus to Group VI metal is about 1:1.5 to less than about 1:12, the molar ratio of the Group VI metal to the Group VIII metal is about 1:1 to about 5:1, and the polymer has a carbon backbone and comprises functional groups having at least one heteroatom. Also provided are a process for preparing such supported catalysts, as well as methods for hydrotreating, hydrodenitrogenation, and/or hydrodesulfurization, using supported catalysts.

The present invention provides a magnetic Fe.sub.2O.sub.3 nanosphere with PNH surface modification and application thereof in water treatment. First, 2,2-bipyridyl-5,5′-dicarboxylic acid is reacted with thionyl chloride to obtain 2,2-bipyridyl-5,5′-diacid chloride; then 2,2-bipyridyl-5,5′-diacid chloride and 1,4,8,11-tetraazacyclotetradecane react in the presence of triethylamine to obtain a polynitrogen heterocyclic polymer; the polynitrogen heterocyclic polymer is added into an aqueous solution with iron salt to obtain a magnetic Fe.sub.2O.sub.3 nanosphere with PNH surface modification which has strong light absorption ability, which improves its ability to catalyze in degradation of tetracycline under visible light, so that the pollutants are removed from water.

The present invention provides a magnetic Fe.sub.2O.sub.3 nanosphere with PNH surface modification and application thereof in water treatment. First, 2,2-bipyridyl-5,5′-dicarboxylic acid is reacted with thionyl chloride to obtain 2,2-bipyridyl-5,5′-diacid chloride; then 2,2-bipyridyl-5,5′-diacid chloride and 1,4,8,11-tetraazacyclotetradecane react in the presence of triethylamine to obtain a polynitrogen heterocyclic polymer; the polynitrogen heterocyclic polymer is added into an aqueous solution with iron salt to obtain a magnetic Fe.sub.2O.sub.3 nanosphere with PNH surface modification which has strong light absorption ability, which improves its ability to catalyze in degradation of tetracycline under visible light, so that the pollutants are removed from water.