The present disclosure relates to compositions, kits and methods that may be used for removal of matrix components, including proteins and lipids, from one or more oligonucleotides.

The present invention provides a phosphate adsorbing agent for blood processing comprising a porous formed article comprising an organic polymer resin and an inorganic ion adsorbent and having a most frequent pore size of 0.08 to 0.70 μm measured with a mercury porosimeter, the phosphate adsorbing agent for blood processing having a biocompatible polymer in the surface of the porous formed article.

The present invention provides a phosphate adsorbing agent for blood processing comprising a porous formed article comprising an organic polymer resin and an inorganic ion adsorbent and having a most frequent pore size of 0.08 to 0.70 μm measured with a mercury porosimeter, the phosphate adsorbing agent for blood processing having a biocompatible polymer in the surface of the porous formed article.

The invention relates to a sorbent for removing metabolic waste products from a dialysis liquid, the sorbent comprising a soluble source of sodium ions. The sorbent comprises an ion exchange system which converts urea to ammonium ions and which is configured to exchange ammonium ions for predominantly hydrogen ions and to exchange Ca, Mg, and K for predominantly sodium ions. The soluble source of sodium ions overcomes an initial drop in sodium concentration in regenerated dialysate. When used in conjunction with an infusion system configured to utilise exchange of Ca, Mg and K for sodium during dialysate regeneration a desired sodium ion concentration can be maintained.

The invention relates to a sorbent for removing metabolic waste products from a dialysis liquid, the sorbent comprising a soluble source of sodium ions. The sorbent comprises an ion exchange system which converts urea to ammonium ions and which is configured to exchange ammonium ions for predominantly hydrogen ions and to exchange Ca, Mg, and K for predominantly sodium ions. The soluble source of sodium ions overcomes an initial drop in sodium concentration in regenerated dialysate. When used in conjunction with an infusion system configured to utilise exchange of Ca, Mg and K for sodium during dialysate regeneration a desired sodium ion concentration can be maintained.

The invention relates to a sorbent for removing metabolic waste products from a dialysis liquid, the sorbent comprising a soluble source of sodium ions. The sorbent comprises an ion exchange system which converts urea to ammonium ions and which is configured to exchange ammonium ions for predominantly hydrogen ions and to exchange Ca, Mg, and K for predominantly sodium ions. The soluble source of sodium ions overcomes an initial drop in sodium concentration in regenerated dialysate. When used in conjunction with an infusion system configured to utilise exchange of Ca, Mg and K for sodium during dialysate regeneration a desired sodium ion concentration can be maintained.

A method for obtaining .sup.225AC from .sup.225Ra having the steps of assembling a column having an inorganic stationary phase; priming the column to immobilize .sup.226Ra .sup.225Ra and natural decay products therefrom; immobilizing the .sup.226Ra, .sup.225Ra, .sup.224Ra, and natural decay products therefrom onto a stationary phase within the column; and eluting the column containing the .sup.225Ra with an aqueous sulfate solution to obtain a milking effluent that contains .sup.225AC. Also provided is a method for obtaining pure .sup.225AC from its isotope parents, the method comprising assembling a column having a stationary phase comprising an inorganic material; priming the column with the isotope parents to immobilize .sup.225Ac, and natural decay products of .sup.225AC; immobilizing the .sup.225Ac, and natural decay products therefrom onto the stationary phase within the column .sup.226Ra, .sup.225Ra, .sup.224Ra; and eluting the column containing the .sup.225AC to obtain an effluent that contains the isotope parents.

A method for obtaining .sup.225AC from .sup.225Ra having the steps of assembling a column having an inorganic stationary phase; priming the column to immobilize .sup.226Ra .sup.225Ra and natural decay products therefrom; immobilizing the .sup.226Ra, .sup.225Ra, .sup.224Ra, and natural decay products therefrom onto a stationary phase within the column; and eluting the column containing the .sup.225Ra with an aqueous sulfate solution to obtain a milking effluent that contains .sup.225AC. Also provided is a method for obtaining pure .sup.225AC from its isotope parents, the method comprising assembling a column having a stationary phase comprising an inorganic material; priming the column with the isotope parents to immobilize .sup.225Ac, and natural decay products of .sup.225AC; immobilizing the .sup.225Ac, and natural decay products therefrom onto the stationary phase within the column .sup.226Ra, .sup.225Ra, .sup.224Ra; and eluting the column containing the .sup.225AC to obtain an effluent that contains the isotope parents.

An aspect of the disclosure relates to a dialysate regenerator for connecting to a dialysis apparatus, the dialysate regenerator including a regenerator inlet for receiving dialysate; a regenerator outlet for dispensing regenerated dialysate; a hydraulic circuit connected between the regenerator inlet and the regenerator outlet, and further including a fluid portioning system to divide a dialysate flow into uniform portions for sequential regeneration An aspect of the disclosure relates to a dialysis system including a dialysis apparatus including: a fresh dialysate input; a spent dialysate output; and the dialysate regenerator, wherein the regenerator inlet may be coupled to the spent dialysate output for receiving spent dialysate, and wherein the regenerator outlet may be coupled to the fresh dialysate input for dispensing regenerated dialysate.

An aspect of the disclosure relates to a dialysate regenerator for connecting to a dialysis apparatus, the dialysate regenerator including a regenerator inlet for receiving dialysate; a regenerator outlet for dispensing regenerated dialysate; a hydraulic circuit connected between the regenerator inlet and the regenerator outlet, and further including a fluid portioning system to divide a dialysate flow into uniform portions for sequential regeneration An aspect of the disclosure relates to a dialysis system including a dialysis apparatus including: a fresh dialysate input; a spent dialysate output; and the dialysate regenerator, wherein the regenerator inlet may be coupled to the spent dialysate output for receiving spent dialysate, and wherein the regenerator outlet may be coupled to the fresh dialysate input for dispensing regenerated dialysate.