A three component composition for use in the treatment of an autoimmune disease where the first component comprises a bimodal synthetic carbon particle mixture; the second component comprises a bimodal synthetic carbon particle mixture and an anion exchange resin and the third component comprises a bimodal synthetic carbon particle mixture and a cation exchange resin.

A method for the manufacture of highly purified .sup.68Ge material for radiopharmaceutical purposes. The invention particularly concerns the production of .sup.68Ge-API (API=Active Pharmaceutical Ingredient) solution complying with the Guidelines for good manufacturing practices (GMP). Starting material for the method of the present invention can be a .sup.68Ge stock solution of commercial or other origin as raw material. Such .sup.68Ge containing raw solutions are purified from potential metal and organic impurities originating from production processes. The radiochemical method disclosed is based on a twofold separation of .sup.68Ge from organic and metallic impurities with two different adsorbent materials. During the first separation phase .sup.68Ge is purified from both organic and metallic impurities by adsorption in germanium tetrachloride form, after which hydrolyzed .sup.68Ge is purified from remaining metallic impurities by cation exchange. The final .sup.68Ge-API-product e.g. fulfills the regulatory requirements for specifications of the GMP production of .sup.68Ge/.sup.68Ga generators.

A method for the manufacture of highly purified .sup.68Ge material for radiopharmaceutical purposes. The invention particularly concerns the production of .sup.68Ge-API (API=Active Pharmaceutical Ingredient) solution complying with the Guidelines for good manufacturing practices (GMP). Starting material for the method of the present invention can be a .sup.68Ge stock solution of commercial or other origin as raw material. Such .sup.68Ge containing raw solutions are purified from potential metal and organic impurities originating from production processes. The radiochemical method disclosed is based on a twofold separation of .sup.68Ge from organic and metallic impurities with two different adsorbent materials. During the first separation phase .sup.68Ge is purified from both organic and metallic impurities by adsorption in germanium tetrachloride form, after which hydrolyzed .sup.68Ge is purified from remaining metallic impurities by cation exchange. The final .sup.68Ge-API-product e.g. fulfills the regulatory requirements for specifications of the GMP production of .sup.68Ge/.sup.68Ga generators.

A continuous resin regeneration system includes a process by which resin in need of being recharged is continuously recharged and cleaned with a plurality of two-set filtration columns so that resin regeneration and the flow of influent is continuous and interrupted. Downstream filtration columns also undergo this cycling but at slower and related rates as the first column with the dirtiest water will naturally degrade resin faster than the downstream columns. Contaminated influent is cleaned by the continuously recharged resin in multiple column sets. The degree of cleaning of earlier filtration columns affects the resin flow rate of later filtration columns.

A vitamin E production method and a vitamin E production device which can highly purify vitamin E in a vitamin E concentrated fraction are provided. A raw oil supply section supplies a raw oil to a series column in which two or more columns including a strongly basic anion exchanger are coupled in series to adsorb vitamin E included in the raw oil on the strongly basic anion exchanger of at least one column from among the series column. A desorption solution supply section supplies a desorption solution to a column on which vitamin E has been adsorbed to desorb vitamin E from the strongly basic anion exchanger of the column.

An ion exchange chromatography column contains an ion exchange stationary phase that includes a charged substrate, a plurality of first particles, and a plurality of second particles. The plurality of first particles each include first ion exchange groups and the first particles are ionically bound to the charged substrate. The plurality of second particles each include second ion exchange groups and the second particles are ionically bound to the charged substrate. The first particles having a first ion exchange group density, and the second particles having a second ion exchange group density. The first ion exchange group density is greater than the second ion exchange group density. The ion exchange chromatography column has a number of zones connected in series where each zone can have a varying level of first ion exchange groups and second ion exchange group from the inlet zone to the outlet zone.

A method for more accurately analyzing the content of a metal impurity in a liquid (ultrapure water) containing a low concentration of the metal impurity includes: passing the liquid through an ion exchanger; eluting and recovering the metal impurity captured in the ion exchanger with an eluent; and analyzing the eluent containing the eluted metal impurity and measuring the content of the metal impurity in the eluent, wherein the ion exchanger is used by connecting multiple ion exchangers of the same ion type in series, the volume of the porous ion exchangers per unit is 0.5 to 5.0 ml, and the differential pressure coefficient is 0.01 MPa/LV/m or less.

A three component composition for use in the treatment of an autoimmune disease where the first component comprises a bimodal synthetic carbon particle mixture; the second component comprises a bimodal synthetic carbon particle mixture and an anion exchange resin and the third component comprises a bimodal synthetic carbon particle mixture and a cation exchange resin.

A three component composition for use in the treatment of an autoimmune disease where the first component comprises a bimodal synthetic carbon particle mixture; the second component comprises a bimodal synthetic carbon particle mixture and an anion exchange resin and the third component comprises a bimodal synthetic carbon particle mixture and a cation exchange resin.

Systems for separating Ra from a mixture comprising at least Ra, Pb, Bi, and Th are provided. The systems can include: a first vessel housing a first media and Th or Bi; a second vessel in fluid communication with the first vessel, the second vessel housing a second media and Pb; and a third vessel in fluid communication with the second vessel, the third vessel housing a third media and Ra, wherein at least one of the first, second, or third medias are different from the other media.

Methods for separating Ra from Pb, Bi, and Th are provided, the methods can include: providing a first mixture comprising Ra, Pb, Bi, and/or Th; providing a system that can include: a first vessel housing a first media; a second vessel in fluid communication with the first vessel, the second vessel housing a second media; and a third vessel in fluid communication with the second vessel, the third vessel housing a third media; and exposing the first mixture to the first media within the first vessel then, through the fluid communication, exposing the first remainder to the second media in the second vessel, then, through fluid communication, exposing the next remainder to the third media in the third vessel, the exposing separating the Th and Bi from the Ra and Pb, and the Ra from the Pb.

Methods for separating Ra from being associated with a media are also provided. The methods can include: exposing the Ra and media to a chelating agent to form a mixture comprising the Ra complexed with the chelating agent.