The present invention provides novel methods of cell disruption and release of biomolecules from a cell. The invention comprises the use of positively and/or negatively charged microparticles comprising ground resin. It is particularly useful for purification of biomolecules from cell culture.

A method of treating an beverage, comprising exposing a beverage to an ion exchange matrix that includes a mixture of cation exchange beads and anion exchange beads each capable of binding to one or more cationic or anionic constituents present in the beverage and thereby reduce concentrations of the one or more cationic or anionic constituents in the beverage and capable of maintaining a pH of the beverage within 0.5 pH units of the beverage's pretreatment pH value. The cationic or anionic constituents have a noxious effect on humans and the cation exchange beads include a cationic mineral form and the anion exchange beads include a chloride mineral form.

An ion exchange membrane according to the present disclosure is provided with: a cation exchange composition body that is composed of cation exchange resin particles and a binder resin; and an anion exchange composition body that is composed of anion exchange resin particles and a binder resin. At least one of the cation exchange composition body and the anion exchange composition body is configured to contain a thermally infusible additive.

The invention relates to a sorbent for removing metabolic waste products from a dialysis liquid, the sorbent comprising a soluble source of sodium ions. The sorbent comprises an ion exchange system which converts urea to ammonium ions and which is configured to exchange ammonium ions for predominantly hydrogen ions and to exchange Ca, Mg, and K for predominantly sodium ions. The soluble source of sodium ions overcomes an initial drop in sodium concentration in regenerated dialysate. When used in conjunction with an infusion system configured to utilise exchange of Ca, Mg and K for sodium during dialysate regeneration a desired sodium ion concentration can be maintained.

An ion exchanger filled cartridge accommodated inside an accommodating container of a metal removing column and in which an ion exchanger is filled is provided. The ion exchanger filled cartridge includes a cylinder portion, an upper lid in which a through hole for a liquid to be treated is formed and which is provided on an upper end of the cylinder portion, a lower lid in which a through hole for a treated liquid is formed and which is provided on a lower end of the cylinder portion, an insertion pipe connected to the lower lid, having an O-ring attached to an outer side, and inserted into a treated liquid discharge pipe provided on a bottom portion of the accommodating container of the metal removing column, and the ion exchanger filled inside the cylinder portion.

An ion exchanger filled cartridge accommodated inside an accommodating container of a metal removing column and in which an ion exchanger is filled is provided. The ion exchanger filled cartridge includes a cylinder portion, an upper lid in which a through hole for a liquid to be treated is formed and which is provided on an upper end of the cylinder portion, a lower lid in which a through hole for a treated liquid is formed and which is provided on a lower end of the cylinder portion, an insertion pipe connected to the lower lid, having an O-ring attached to an outer side, and inserted into a treated liquid discharge pipe provided on a bottom portion of the accommodating container of the metal removing column, and the ion exchanger filled inside the cylinder portion.

The present invention relates to a method for producing purified water comprising a step of passing water through a mixed bed ion exchanger comprising beads having a diameter of less than 0.5 mm, as well as to a module comprising an ultrafiltration means and a mixed bed ion exchanger as defined above and a water treatment system for producing ultrapure water comprising ultrafiltration means and a mixed bed ion exchanger as defined above, wherein the ultrafiltration means is located upstream of said mixed bed ion exchanger.

The present invention relates to a method for producing purified water comprising a step of passing water through a mixed bed ion exchanger comprising beads having a diameter of less than 0.5 mm, as well as to a module comprising an ultrafiltration means and a mixed bed ion exchanger as defined above and a water treatment system for producing ultrapure water comprising ultrafiltration means and a mixed bed ion exchanger as defined above, wherein the ultrafiltration means is located upstream of said mixed bed ion exchanger.

The present invention relates to a method for producing purified water comprising a step (a) of passing water through a first mixed bed ion exchanger comprising beads having a diameter between 0.5 and 0.7 mm and a step (b) of passing water through a second mixed bed ion exchanger comprising beads having a diameter of less than 0.5 mm. The invention further relates to a module comprising the first and second mixed bed ion exchanger and to a water treatment system for producing ultra-pure water comprising the first and second mixed bed ion exchanger.

The present invention relates to a method for producing purified water comprising a step (a) of passing water through a first mixed bed ion exchanger comprising beads having a diameter between 0.5 and 0.7 mm and a step (b) of passing water through a second mixed bed ion exchanger comprising beads having a diameter of less than 0.5 mm. The invention further relates to a module comprising the first and second mixed bed ion exchanger and to a water treatment system for producing ultra-pure water comprising the first and second mixed bed ion exchanger.