The present invention relates to a method for preparing graphene using a novel block copolymer. The present invention has features that, by using the block copolymer to mediate graphene that is hydrophobic and a solvent of a feed solution that is hydrophilic, the exfoliation efficiency of graphene as well as the dispersion stability thereof can be increased during high-pressure homogenization.

The invention relates to a microfluidic system based on active control of flow resistance and balancing pressures in microfluidic channels and an improved method for enhancing reactions with magnetic beads used in disposable microfluidic devices and cartridges for use in, but not limited to, in-vitro diagnostics. The microfluidic system and device of the invention does not utilize mechanical moving parts to control the fluid flow and has no external fluidic connection to the instrument or fluidics controller. The microfluidic system and device combines magnetic control over the movement of magnetic detection beads with electric field and convective enhancement of the movement of analytes and/or or reagentss surrounding the magnetic detection beads, thereby enabling movement of magnetic beads and analytes in the same direction or in different directions. The present invention thereby provides significantly enhanced interactions between analytes and/or reagents with the magnetic beads, which yields higher sensitivity for detection.

An apparatus suitable for clamping at least one microfluidic device, which includes (i) a fluid-tight chamber having a fluid inlet, the chamber being configured to receive a microfluidic device to be clamped by compression of at least one deformable part of the microfluidic device under the action of a pressure of a clamping fluid in the chamber, and (ii) a perfusion fluid management system configured to adjust the pressure of a perfusion fluid in the microfluidic device in such a way that, during a clamping operation, the pressure of the clamping fluid in the chamber is strictly higher than the pressure of the perfusion fluid in the microfluidic device.

The present disclosure provides fluidic devices and fluidic device assemblies, including microfluidic devices and cartridges comprising the same, that in illustrative embodiments, can be used to make particles or protein precipitates, or to monitor precipitate formation. The fluidic devices typically include channels that connect a reaction well to an inlet port and an outlet port, and a fluidic constriction channel that is configured to help retain fluids in the reaction well and/or promote mixing within the reaction well. In some aspect, fluidic devices are interconnected into fluidic assemblies that can be used in continuous process methods.

A catalytic microscale reactor with spiral reactor geometry may have a high surface area to volume ratio, high catalytic surface area, high heat transfer surface area, long residence time, and high single pass conversion. The catalytic surface may be treated with micro sphere spacer particles which serve to maintain the space between them at an engineered distance without the need for precise manufacturing techniques. The design of the reactor may allow for a catalyst surface to be removed, uncoiled, refurbished, and recoiled in an automated continuous process. An automated continuous process may be suitable both for initially preparing a new catalytic surface as well as refurbishing a fouled catalytic surface and may the time and cost to prepare a new surface.

The present invention relates to a method for preparing graphene using a novel block copolymer. The present invention has features that, by using the block copolymer to mediate graphene that is hydrophobic and a solvent of a feed solution that is hydrophilic, the exfoliation efficiency of graphene as well as the dispersion stability thereof can be increased during high-pressure homogenization.

A flow reactor has a module having a process fluid passage with an interior surface, a portion of the passage including a cross section along the portion having a cross-sectional shape, and a cross-sectional area with multiple minima along the passage. The cross-sectional shape varies continually along the portion and the interior surface of the portion includes either no pairs of opposing flat parallel sides or only pairs of opposing flat parallel sides which extend for a length of no more than 4 times a distance between said opposing flat parallel sides along the portion and the portion contains a plurality of obstacles distributed along the portion.

A method for continuously processing at least two liquid feed streams is provided. A system for continuously processing at least two liquid feed streams is also provided.

In an embodiment, the present disclosure pertains to a method of making magnetic nanoparticles through the utilization of a microfluidic reactor. In some embodiments, the microfluidic reactor includes a first inlet, a second inlet, and an outlet. In some embodiments, the method includes applying a magnetic nanoparticle precursor solution into the first inlet of the microfluidic reactor through a first flow rate and applying a reducing agent into the second inlet of the microfluidic reactor through a second flow rate. In some embodiments, the magnetic nanoparticles are produced in the microfluidic reactor and collected from the outlet of the microfluidic reactor. In an additional embodiment, the present disclosure pertains to a composition including a plurality of magnetic nanoparticles. In a further embodiment, the present disclosure pertains to a microfluidic reactor.

The present invention relates to a continuous micro-electro-flow reactor system for ultra-fast, oxidant free, C—C coupling reaction for making symmetrical biaryls and analogs thereof. This invention further relates to the said process for preparation of antiviral drug, daclatasvir of general formula I.