A method for separating biological entities in a fluid sample, which contains small, medium, and large biological entities, includes the steps introducing the fluid sample into a first microfluidic device as two streams along two sidewalls thereof; applying a first power to the first microfluidic device to exert a first acoustic radiation pressure to produce a first output fluid having a higher relative fraction of the large biological entities than the fluid sample and a second output fluid having a lower relative fraction of the large biological entities than the fluid sample; introducing the second output fluid into a second microfluidic device as two streams along two sidewalls thereof; and applying a second power, which is higher than the first power, to the second microfluidic device to exert a second acoustic radiation pressure to produce a third output fluid having a higher relative fraction of the medium biological entities than the fluid sample.

An automated radiopharmaceutical production and quality control system includes a particle accelerator, a radiopharmaceutical micro-synthesis subsystem, and quality control subsystem. The micro-accelerator of the improved biomarker generator is optimized for producing radioisotopes useful in synthesizing radiopharmaceuticals in quantities on the order of multiple unit doses, allowing for significant reductions in size, power requirements, and weight when compared to conventional radiopharmaceutical cyclotrons. The radiopharmaceutical micro-synthesis subsystem encompasses a small volume chemical synthesis system comprising a microreactor and/or a microfluidic chip and optimized for synthesizing the radiopharmaceutical in small quantities, allowing for significant reductions in processing time and in the quantity of radioisotope required. The automated quality control subsystem is used to test the composition and characteristics of the radiopharmaceutical to ensure that it is safe to inject.

A method of a polyurethane foam includes the following steps of: (1) simultaneously pumping a mixed solution prepared from hydrogen peroxide, an organic acid, a catalyst and a stabilizer and a vegetable oil into a first microstructured reactor of a micro-channel modular reaction device for reacting to obtain a reaction solution containing epoxidized vegetable oil; (2) simultaneously pumping the reaction solution containing the epoxidized vegetable oil obtained from the step (1) and a compound of formula III into a second microstructured reactor of the micro-channel modular reaction device for reaction to obtain a vegetable oil polyol; and (3) reacting the vegetable oil polyol prepared from the step (2) with a foam stabilizer, a cyclohexylamine, an isocyanate and a foaming agent cyclopentane for foaming so as to prepare a rigid polyurethane foam.

Apparatuses and methods are described herein for processing polynucleotides in a sealed path environment. The apparatuses include optical sensors to monitor operations and to track material usage for good manufacturing practice.

Methods and apparatuses for making and using therapeutics, including in particular mRNA therapeutics, that separate double-stranded RNA from single-stranded RNA as part of a continuous flow. These methods and apparatuses may include formulation of an RNA therapeutic using a permeable insert integrated into a microfluidic path device. In particular, these methods and apparatuses may include formulation of an RNA therapeutic by removing dsRNA from a solution of RNA by within a microfluidic path device including a cellulose material.

A method for producing a chemical reactor device based on a fluid flow comprises obtaining a substrate with a fluid channel defined by a channel wall, in which an ordered set of silicon pillar structures is positioned in the fluid channel and electrochemically anodising at least the silicon pillar structures to make the silicon pillar structures porous at least to a certain depth. After the anodising, the substrate and pillar structures are thermally treated, the treatment being carried out at a temperature, with a duration and in an atmosphere such that any silicon oxide layer formed has a thickness of less than 20 nm. The substrate and the pillar structures are further functionalized.

An object of the present invention is to provide a flow type reaction device which is capable of maintaining reaction efficiency and productivity which are sufficient for practical use for a long time, and reducing the size and cost of the reaction device, and the present invention provides a flow type reaction device (1) for continuously reacting two or more kinds of raw materials, including a mixing section (10) which is configured to mix two or more kinds of the raw materials, and a reaction section (20) which is provided on a secondary side with respect to the mixing section (10), and configured to obtain a product by reacting two or more kinds of the raw materials, the mixing section (10) includes a mixing device (13) which is configured to mix two or more kinds of the raw materials, and two or more supply pipes (L11, L12) which are configured to supply each of two or more kinds of the raw materials to the mixing device (13), the supply pipes (L11, L12) are respectively connected to the mixing device (13), and at least one of the supply pipes (L11) has, in the vicinity of a connection portion of the supply pipe (L11) with the mixing device (13), a suppression mechanism which is configured to suppress movement of a fluid from the mixing device (13) to the supply pipe (L11).

A device for continuously manufacturing acrylate compound and a method for continuously manufacturing acrylate compound are provided. The device for continuously manufacturing acrylate compound includes a reaction system, a feed tank and a collection tank. The feed tank connects to the inlet port of the reaction system, in order to introduce an alcohol compound and acrylic acid compound into the reaction system. The collection tank connects to the outlet port of the reaction system, in order to collect the acrylate compound. In particular, the reaction system includes at least two reaction units, an inlet port and an outlet port, wherein each reaction unit includes a microreactor and a centrifugal element.

Disclosed are modular chemical reaction systems and methods of using such chemical reaction systems. The disclosed systems can have a substrate layer and a plurality of modules selectively mounted to an outer surface of the substrate layer. The substrate layer can include flow connectors that cooperate with the modules to form a fluid flow pathway for performing at least one step of a chemical reaction. At least one of the modules can be a process module, such as a reactor or separator. The modules can also include at least one regulator module. The system can also include at least one analysis device that analyzes at least one characteristic of the chemical reaction as the reaction occurs. The system can also include processing circuitry that monitors and/or optimizes the chemical reaction based on feedback received from the analysis device or other system components.

Aspects of the present disclosure relate to reconfigurable chemical synthesis systems and related components and methods. In one aspect, a fluidic system comprises a plurality of fluid outlets, a plurality of fluid inlets, a plurality of tensioners, and a plurality of flexible conduits associated with the plurality of tensioners, wherein at least one flexible conduit of the plurality of flexible conduits is configured to fluidically connect a fluid outlet of the plurality of fluid outlets and a fluid inlet of the plurality of fluid inlets. Another aspect relates to a method in which ends of a plurality of flexible conduits are physically moved along paths, one after the other, prior to flowing material through the flexible conduits, after which the ends of the flexible conduits are again physically moved.