A method for producing a chemical reactor, wherein the chemical reactor comprises one or more effective channels which comprise pillar structures, an input connected to one of the effective channels to allow fluid/gas into the effective channels and an output connected to one of the effective channels to remove at least one component of the liquid/gas. The method comprises obtaining an initial design of the reactor, further introducing into the initial design at least a structured area positioned adjacent to an effective channel of the one or more effective channels located at the edge of the initial design, the structured area not being fluidly connected to one of the effective channels, to obtain a further design and the production of the reactor according to the further design

Microfluidic methods and systems are provided for continuous flow synthesis and active loading of liposomes, which include a liposome formation region configured to form a population of liposomes and a microdialysis region downstream from the liposome formation region and configured to form a transmembrane gradient for active drug loading of the liposomes. Microfluidic methods and systems for high throughput production of liposomes are also provided featuring high aspect ratio microchannels.

The invention generally provides systems and methods for producing a chemical product. In certain embodiments, the invention provides systems that include a chemical product production unit. The chemical production unit includes a plurality of microfluidic modules configured to be fluidically coupled to each other in an arrangement that produces a chemical product from an input of a plurality of starting reagents that react with each other due to conditions within the plurality of microfluidic modules through which the starting reagents flow. The system also includes a droplet dispenser fluidically coupled to the chemical product production unit that forms and dispenses droplets of the chemical product.

The present disclosure is directed to systems and methods for reforming a hydrocarbon fuel to increase the cetane value of the hydrocarbon fuel. The system includes a microstatic mixer and a microchannel reactor downstream of the microstatic mixer. The microchannel reactor includes a microchannel with an NHPI catalyst coated onto the walls of the microchannel. A hydrocarbon fuel and an oxygen-containing gas are combined and mixed in the microstatic mixer to produce a combined stream and the combined stream is passed through the microchannel. The microchannel reactor includes a heat transfer system. The hydrocarbon fuel and oxygen-containing gas are contacted in the microchannel in the presence of the catalyst at a reaction temperature sufficient to produce a reformed hydrocarbon fuel having a cetane value greater than a cetane value of the starting hydrocarbon fuel.

The present disclosure is directed to systems and methods for reforming a hydrocarbon fuel to increase the cetane value of the hydrocarbon fuel. The system includes a microstatic mixer and a microchannel reactor downstream of the microstatic mixer. The microchannel reactor includes a microchannel with an NHPI catalyst coated onto the walls of the microchannel. A hydrocarbon fuel and an oxygen-containing gas are combined and mixed in the microstatic mixer to produce a combined stream and the combined stream is passed through the microchannel. The microchannel reactor includes a heat transfer system. The hydrocarbon fuel and oxygen-containing gas are contacted in the microchannel in the presence of the catalyst at a reaction temperature sufficient to produce a reformed hydrocarbon fuel having a cetane value greater than a cetane value of the starting hydrocarbon fuel.

The present disclosure provides fluidic devices and fluidic device assemblies, including microfluidic devices and cartridges comprising the same, that in illustrative embodiments, can be used to make particles or protein precipitates, or to monitor precipitate formation. The fluidic devices typically include channels that connect a reaction well to an inlet port and an outlet port, and a fluidic constriction channel that is configured to help retain fluids in the reaction well and/or promote mixing within the reaction well. In some aspect, fluidic devices are interconnected into fluidic assemblies that can be used in continuous process methods.

A full continuous flow synthesis process of fluorine-containing aromatic hydrocarbon compounds. Aromatic amine and hydrogen fluoride are respectively pumped into thermostats A and B, then flow into micro-channel reactor C for salt forming reaction whose temperature is kept constant; sulfuric acid solution of nitrosylsulfuric acid is pumped into thermostat D; after keeping the temperature constant, the sulfuric acid solution of nitrosylsulfuric acid and salt forming product flowing out from the micro-channel reactor C flow into micro-channel reactor E for diazotization reaction; the obtained product flows into micro-channel reactor F for thermal decomposition reaction, is cooled in cooler G, then enters three-phase separator H for continuous separation, fluorine-containing aromatic hydrocarbon crude product is subjected to continuous alkaline washing, drying and rectification to obtain fluorine-containing aromatic hydrocarbon finished product, and mixture of hydrofluoric acid and sulfuric acid is continuously distilled to obtain hydrogen fluoride and sulfuric acid.

A method of manufacturing core-shell particles comprises: filling a buffer into a rotor, which is extended in a longitudinal direction, and is accommodated so as to be spaced apart from an inner wall side of a non-rotational hollow cylinder extended in a longitudinal direction and then discharging air to outside; rotating the rotor after terminating the filling; forming a core-shell precursor by supplying raw materials from a first storage and a second storage, which comprise a material forming a core, into an interior of the cylinder in which the rotor rotates; supplying a shell material for coating the core to the interior of the cylinder in which a core-type precursor is formed; separating a liquid comprising core-shell particles formed through the supplying into a solid and a liquid; and drying the core-shell particles obtained through the separating.

Aspects of the present disclosure relate to reconfigurable chemical synthesis systems and related components and methods. In some embodiments, the described systems comprise one or more fluidic connector units, wherein each fluidic connector unit comprises a plurality of flexible conduits. In certain cases, a system comprising one or more fluidic connector units is configured to synthesize a first chemical compound by providing a plurality of fluidic connections between a plurality of fluid outlets (e.g., outlets of chemical reagent sources, outlets of pumps) and a plurality of fluid inlets (e.g., inlets of reaction modules, inlets of pumps) through the plurality of flexible conduits. In certain cases, the system is subsequently reconfigured by resetting the system (e.g., disconnecting each fluidic connection) and/or configuring the system to synthesize a second, different chemical compound (e.g., disconnecting one or more fluidic connections and providing one or more additional fluidic connections). According to some embodiments, in order to avoid tangling the flexible conduits during reconfiguration of the system, the fluidic connections are disconnected according to certain inventive methods described herein. In certain embodiments, fluidic connections are disconnected in reverse order relative to the order in which they were formed (e.g., the newest fluidic connection is disconnected first, the oldest fluidic connection is disconnected last). In certain embodiments, certain fluidic connections are targeted for disconnection, and additional fluidic connections are disconnected if they overlap the targeted fluidic connections and were formed more recently than the targeted fluidic connections. The fluidic connection and/or disconnection steps may, in some embodiments, be performed by a robotic manipulator.

Microfluidic radiopharmaceutical production system and process for synthesizing per run approximately, but not less than, ten (10) unit doses of radiopharmaceutical biomarker for use in positron emission tomography (PET). A radioisotope from an accelerator or other radioisotope generator is introduced into a reaction vessel, along with organic and aqueous reagents, and the mixture heated to synthesize a solution of a pre-selected radiopharmaceutical. The solution is purified by passing through a combination of solid phase extraction purification components, trap and release components, and a filter. The synthesis process reduces waste and allows for production of biomarker radiopharmaceuticals on site and close to the location where the unit dose will be administered to the patient. On-site, as-needed production of radiopharmaceuticals in small doses reduces the time between synthesis of the radiopharmaceutical and administration of that radiopharmaceutical, minimizing loss of active isotopes through decay and allowing production of lesser amounts of radioisotopes overall.