The present invention relates to a Palladium (II)-catalyzed C(sp.sup.3)H alkynylation of amines using picolinamide as directing group. The developed alkynylation strategy is simple, efficient, and tolerant of various ring size including five to eight member cyclic, quaternary amines, and N-heterocyclic motifs.

The present invention relates to a Palladium (II)-catalyzed C(sp.sup.3)-H alkynylation of amines using picolinamide as directing group. The developed alkynylation strategy is simple, efficient, and tolerant of various ring size including five to eight member cyclic, quaternary amines, and N-heterocyclic motifs.

Internal dienes (including supported versions) and their Periodic Groups IX, X and Pt Group Metal Complexes as catalysts for hydrosilylation/coupling reactions. A process for the hydrosilylation of an unsaturated compound comprising reacting (a) a silyl or siloxy hydride with (b) an unsaturated compound in the presence of (c) one or more platinum complex containing said internal dienic ligand or (d) a platinum compound and one or more said internal dienic ligand additive. For Ru, Os, Co, Rh, Ir, Ni, or Pd, catalyzed processes such as CC/CN or CO coupling comprising reacting (a) an aromatic halide/vinyl halide/an aromatic triflate with (b) a primary/secondary amine/amide, an alcohol/aryl boronic acid/aryl boronate/vinyl halide or an activated olefin in the presence of (c) a Group IX or X or Pt Group metal complex containing said dienic ligand(s) or (d) a suitable compound of these metals and of one or more said internal dienic ligand additive.

The present disclosure provides a method for efficiently producing and providing compounds having a spirooxindole skeleton, for example compounds having a spirooxindole skeleton and having antitumor activity that inhibit the interaction between Mdm2 protein and p53 protein, or intermediates thereof, using an asymmetric catalyst. Compounds having optically active tricyclic dispiroindole skeletons are obtained through catalytic asymmetric 1,3-dipolar cycloaddition reaction using ketimine as a reaction substrate and using a chiral ligand and a Lewis acid.

Catalytic processes employing rhodium complexes are disclosed, wherein the catalytic processes involve an initial step of activation of a CH bond present within a hydrocarbon substrate. In contrast to prior art techniques, the catalytic processes of the invention can be conducted at low temperatures, and the catalytic compounds are themselves highly recyclable. Also disclosed are the rhodium complexes themselves and processes of making them.

The present invention refers to processes for catalytic reversible alkene-nitrile interconversion through controllable HCN-free transfer hydrocyanation.

The present invention is directed to processes from producing beta-lactone and beta-lactone derivatives using heterogenous catalysts. In preferred embodiments of the present invention, the processes comprise the steps: passing a feed stream comprising an epoxide reagent and a carbon monoxide reagent to a reaction zone; contacting the epoxide reagent and the carbon monoxide reagent with a heterogenous catalyst to produce a beta-lactone product in the reaction zone; and removing the beta-lactone product from the reaction zone. In preferred embodiments, the heterogenous catalyst comprises a solid support containing a cationic Lewis acid functional group and a metal carbonyl compound comprising at least one of anionic metal carbonyl compound or a neutral metal carbonyl compound. In certain preferred embodiments, the epoxide reagent and carbon monoxide reagent have a biobased content.

Provided herein is a compound of formula (I): ##STR00001##
wherein each R is independently selected from the group consisting of C.sub.1-8 alkyl, C.sub.1-8 heteroalkyl having 1-4 heteroatoms independently selected from N, O, and S, C.sub.3-6 cycloalkyl, 3-10 membered heterocycloalkyl having 1-4 heteroatoms independently selected from N, O, and S, C.sub.6-10 aryl, and 5-10 membered heteroaryl having 1-4 heteroatoms independently selected from N, O, and S; each X is independently selected from OH, PAr.sub.2, P(O)Ar.sub.2, OPAr.sub.2, C.sub.3-6 cycloalkyl, 3-10 membered heterocycloalkyl having 1-4 heteroatoms independently selected from N, O, and S or each X together form O.sub.2PNR.sub.2; Ar is C.sub.6-10aryl; and each R is independently selected from hydrogen and C.sub.1-8 alkyl. Also provided are methods of making and using the compound of formula (I).

The present disclosure provides a method for efficiently producing and providing compounds having a spirooxindole skeleton, for example compounds having a spirooxindole skeleton and having antitumor activity that inhibit the interaction between Mdm2 protein and p53 protein, or intermediates thereof, using an asymmetric catalyst. Compounds having optically active tricyclic dispiroindole skeletons are obtained through catalytic asymmetric 1,3-dipolar cycloaddition reaction using ketimine as a reaction substrate and using a chiral ligand and a Lewis acid.

Disclosed are complexes and methods of using the complexes as catalysts for addition of amines to unsaturated electrophiles, as well as novel compounds produced by the disclosed complexes and methods. The disclosed methods may utilize the disclosed complexes as catalysts for adding unprotected primary amines and secondary amines to unsaturated electrophiles in an enantioselective manner to produce novel compounds which may include amino substituted succinimide compounds.