The present disclosure provides a method for efficiently producing and providing compounds having a spirooxindole skeleton, for example compounds having a spirooxindole skeleton and having antitumor activity that inhibit the interaction between Mdm2 protein and p53 protein, or intermediates thereof, using an asymmetric catalyst. Compounds having optically active tricyclic dispiroindole skeletons are obtained through catalytic asymmetric 1,3-dipolar cycloaddition reaction using ketimine as a reaction substrate and using a chiral ligand and a Lewis acid.

The present invention relates to an improved method of preparing metal complexes, in particular carbene-metal complexes. The method comprises the step of subjecting a salt of formula Z.sup.+—X.sup.− and a non-ionic metal salt of formula ML.sub.n or subjecting a metallate of formula Z.sup.+ . . . ML.sub.nX.sup.− to a mechanical mixing process in the presence of a base. The method allows to formation of heterocyclic carbene metal complexes such as a nitrogen-containing heterocyclic carbene (NHC)-metal complexes. The invention also relates to the use of metal complexes, in particular carbene-metal complexes such as heterocyclic carbene-metal complexes obtainable by the method according to the present invention as catalysts.

A method for synthesizing a chiral -hydroxy acid ester compound is disclosed. The method includes the steps of: using an aldehyde compound and a monoalkyl malonate as raw materials, using a metal and a chiral ligand as a catalyst to make the raw materials be directly and fully reacted in an organic solvent and form a reaction solution, and separating and purifying the reaction solution to obtain the highly stereoselective -hydroxy acid ester compound. The beneficial effects are mainly embodied in: 1. simple operation; 2. rapidly constructing a highly stereoselective -hydroxy acid ester skeleton structure molecule; 3. high reaction yield and good stereoselectivity. Therefore, the invention has high basic research significance, industrial production value and social economic benefit.

A method for preparing a porous nano-fiber heterostructure photocatalytic filter screen includes: preparing a noble metal nanostructure with tunable spectra and a heterostructure composite photocatalyst of a photocatalytic material; and preparing a large area and multilayer porous nano-fiber filter screen structure, while utilizing a scattering enhancement effect of metal nanoparticles in an porous optical fiber to realize repeated conduction of sunlight in the optical fiber and finally interact with the composite photocatalyst on a surface to improve photocatalytic efficiency. Preparation of the heterostructure composite photocatalyst with a wide spectral response of and tunable visible to infrared band spectra is realized, at the same time, with reference to high adsorbability, high light transmission of nanometer fiber and unique optical characteristics of metal nanoparticles, an air purification filter screen with a high sunlight utilization rate and a high catalytic degradation capability is creatively provided.

Methods of synthesizing compounds using CO.sub.2 as a directing group for CH functionalization, and compounds made thereby, are described.

Polydentate macrocyclic NHCs (NHC ligands) and related methods are disclosed. Such ligands advantageously facilitate a variety of ligand coordination modes and stabilize oxidation states of metal complexes with a number of coordination environments and shapes. The NHC ligands described herein comprise pendant groups configured to facilitate a variety of reactions including: cis-trans isomerization, proton shuttling and facilitating changes in coordination environments as a result of redox reactions.

Use of transition metal complexes of the formula (I) in organic light-emitting diodes

##STR00001## where: M.sup.1 is a metal atom; carbene is a carbene ligand; L is a monoanionic or dianionic ligand; K is an uncharged monodentate or bidentate ligand selected from the group consisting of phosphines; CO; pyridines; nitriles and conjugated dienes which form a complex with M.sup.1; n is the number of carbene ligands and is at least 1; m is the number of ligands L, where m can be 0 or 1; o is the number of ligands K, where o can be 0 or 1; where the sum n+m+o is dependent on the oxidation state and coordination number of the metal atom and on the denticity of the ligands carbene, L and K and also on the charge on the ligands carbene and L, with the proviso that n is at least 1, and also

an OLED comprising these transition metal complexes, a light-emitting layer comprising these transition metal complexes, OLEDs comprising this light-emitting layer, devices comprising an OLED according to the present invention, and specific transition metal complexes comprising atb least two carbene ligands.

A method and composition for reducing halogenated decomposition byproducts and precursors of the byproducts in the water and air of an aquatic facility. The composition contains a water soluble metal-porphyrin catalyst that accelerates oxidation of the halogenated decomposition byproducts and their precursors. The catalyst remains stable and only requires replenishment relative to the makeup water added to the treated aquatic facility. The average time interval of replenishment can be measured in weeks or months.

The present invention relates to supported metal catalysts, wherein the catalysts are modified by at least one amine, a method for the preparation thereof and hydrogenation processes utilising the supported metal catalysts.

A method for synthesizing a chiral -hydroxy acid ester compound is disclosed. The method includes the steps of: using an aldehyde compound and a monoalkyl malonate as raw materials, using a metal and a chiral ligand as a catalyst to make the raw materials be directly and fully reacted in an organic solvent and form a reaction solution, and separating and purifying the reaction solution to obtain the highly stereoselective -hydroxy acid ester compound. The beneficial effects are mainly embodied in: 1. simple operation; 2. rapidly constructing a highly stereoselective -hydroxy acid ester skeleton structure molecule; 3. high reaction yield and good stereoselectivity. Therefore, the invention has high basic research significance, industrial production value and social economic benefit.