Embodiments of the present invention are directed to devices, systems and methods adapted for implementing intermittent displacement of blood to mitigate peripheral nerve neuropathy such as that induced by chemotherapeutic agents (i.e., chemotherapy-induced neuropathy (CIN)) that are administered to a patient. Such devices, systems and methods advantageously provide for precise, uniform and controlled blood flow occluding (and optionally blood displacing) compression along irregular surfaces of an appendage of a patient. Such precise, uniform and controlled blood occluding compression is imparted upon the epidermal and dermis skin layers within the aforementioned areas of a patient's extremities to decrease the time that free nerve endings located in the epidermal and encapsulated nerve endings located in the dermis skin layers are exposed to nerve damaging chemotherapy chemicals, thereby substantially decreasing CIN caused by prolonged exposure to such chemicals.

Embodiments of the present invention are directed to devices, systems and methods adapted for implementing intermittent displacement of blood to mitigate peripheral nerve neuropathy such as that induced by chemotherapeutic agents (i.e., chemotherapy-induced neuropathy (CIN)) that are administered to a patient. Such devices, systems and methods advantageously provide for precise, uniform and controlled blood flow occluding (and optionally blood displacing) compression along irregular surfaces of an appendage of a patient. Such precise, uniform and controlled blood occluding compression is imparted upon the epidermal and dermis skin layers within the aforementioned areas of a patient's extremities to decrease the time that free nerve endings located in the epidermal and encapsulated nerve endings located in the dermis skin layers are exposed to nerve damaging chemotherapy chemicals, thereby substantially decreasing CIN caused by prolonged exposure to such chemicals.

Apparatus, methods, and systems are provided for applying, or use with, a multibaric treatment protocol to a human limb. The apparatus may comprise a bag formed to surround at least a portion of the limb; a connection arrangement mounted to a wall of the bag in a distal portion of the bag, effective to enable therethrough a flow of a gas between the pressure-regulating device and an interior space of the bag; and a gas-permeable strip affixed to or integral with an interior surface of the bag.

A massage system includes a massage head configured to contact a treatment region of a patient during a massage treatment procedure, a body having a handle, a connector having a first end and a second end, wherein the first end is releasable secured to the body and the second end is coupled to the massage head, a motor positioned within the body and configured to drive movement of the massage head relative to the body, and a platform configured to be placed against the patient during a massage treatment procedure. The platform defines an opening. The platform is positioned so that the massage head extends at least partially through the opening during movement of the massage head relative to the body, and the platform surrounds the massage head in at least one dimension during movement of the massage head relative to the body.

Provided herein is an inflatable compression device for performing compression therapy to an amputated limb of a subject, the device includes a compression sleeve and an adjustable compression pocket configured to provide compression therapy to the stump face and adjust to the length of the amputated limb. Further provided are systems and methods of using the same.

A treatment device for removing heat from subcutaneous lipid-rich cells of a subject having an actuator that provides mechanical energy to the tissue. The mechanical energy provided may include a vibratory component that can range between low and ultra-high frequencies, and such energy may include various combinations of two or more frequencies tailored to produce the desired effect on the subcutaneous tissue. Disruption of adipose tissue cooled by an external treatment device may be enhanced by applying mechanical energy to cooled tissue. Furthermore, such mechanical energy may impart a vibratory effect, a massage effect, a pulsatile effect, or combinations thereof on the tissue.

A wearable health management system includes a flexible member configured to be worn on an affected area by a patient. At least one actuator is operably coupled to the flexible member. The at least one actuator is configured to be adjusted between a deployed state and a non-deployed state. At least one of a photoplethysmogram sensor and a bioimpedance sensor is coupled to the flexible member to obtain one or more health metrics from the patient. A controller is in communication with the at least one actuator. The controller is configured to adjust the at least one actuator to the deployed state to provide a selected pressure to the affected area.

A treatment device for removing heat from subcutaneous lipid-rich cells of a subject having an actuator that provides mechanical energy to the tissue. The mechanical energy provided may include a vibratory component that can range between low and ultra-high frequencies, and such energy may include various combinations of two or more frequencies tailored to produce the desired effect on the subcutaneous tissue. Disruption of adipose tissue cooled by an external treatment device may be enhanced by applying mechanical energy to cooled tissue. Furthermore, such mechanical energy may impart a vibratory effect, a massage effect, a pulsatile effect, or combinations thereof on the tissue.

A method of treating a reflexology zone to reduce aging using pressure pulses or shock waves has the steps of: placing an applicator head of an acoustic shock wave or pressure pulse generator or source at a reflexology zone; coupling the applicator head directly or indirectly to an exposed surface of the skin near the reflexology zone; and activating the generator or source to emit pressure pulses or acoustic shock waves through the skin to the reflexology zone to reduce, reverse or stop cell senescence or aging and apoptosis.

A massage pillow configured to be positioned over a fluid jet includes a cushion and a retaining assembly. The cushion includes a front surface, a rear surface, and side surfaces extending there between. The rear surface includes an annular edge defining an opening providing access to an interior of the cushion sized to at least partially cover the jet. The retainer assembly includes an opening configured to align with the jet and a peripheral edge configured to retain the annular edge of the cushion. The retainer assembly is configured to be removably fixed to a wall surrounding the jet with the jet aligned with the opening of the retainer assembly and the opening of the cushion, such that fluid expelled from the jet passes into the interior of the cushion, so that the pillow provides massage and/or warmth due to the expelled fluid.