A clinical diagnostic sample analyzer for analyzing a sample of a patient is disclosed. The analyzer includes a telescoping closed-tube sampling assembly with a sample probe concentrically housed within a piercing probe and a venting mechanism. The closed-tube sampling assembly is used for aspirating a sample from a sample tube for analysis by a clinical diagnostic sample analyzer.

This pipette tip includes: a first part having an outer diameter which increases gradually from a distal end side toward a proximal end side; a second part in which a taper angle of an outer surface of the second part is smaller than a taper angle of an outer surface of the first part; a third part in which a taper angle of an outer surface of the third part is larger than the taper angle of the outer surface of the first part; and a fourth in which a taper angle of an outer surface of the fourth part is smaller than the taper angle of the outer surface of the third part.

A pipette has a first chamber and a second chamber that connects to the first chamber and extends with an outlet channel to a pipette tip. The chambers are separated from one another by a longitudinally displaceable piston having a piston non-return valve. The second chamber has a chamber non-return valve which is arranged upstream of the outlet channel. An associated method includes recirculating the liquid in the first chamber, filling the first chamber with the liquid via a direct feed line, filling the second chamber with the liquid from the first chamber by pulling back the piston in the filling position toward the first chamber with the piston non-return valve open and with the chamber non-return valve closed, and emptying the second chamber by advancing the piston in the emptying position towards the outlet channel, with the piston non-return valve closed and the chamber non-return valve open.

A droplet generating apparatus, system, and method are disclosed. Based on a relative vibration between a micro-pipe and a container containing a second liquid, a first liquid flowing out from an outlet end of the micro-pipe can be detached from the micro-pipe by a fluid shear force of the second liquid to form droplets in the second liquid. Multitudinous quantitative and uniform droplets can be generated precisely and accurately in the present disclosure.

A stand for a pipet controller is provided that includes a housing with a cradle arranged to hold a pipet controller in at least three distinct orientations relative to the housing. The at least three distinct orientations include a first orientation for storing the pipet controller when not in use, a second orientation for storing the pipet controller between intermittent uses such that a grip of the pipet controller is able to be ergonomically gripped by a user of the pipet controller, and a third orientation for storing the pipet controller such that, if a pipet is connected to a pipet connector of the pipet controller, the connected pipet does not contact the stand nor a surface supporting the base of the stand. The stand can also be a charger for charging the pipet controller in at least one orientation.

Disclosed are methods and devices for detection of ion migration and binding, utilizing a nanopipette adapted for use in an electrochemical sensing circuit. The nanopipette may be functionalized on its interior bore with metal chelators for binding and sensing metal ions or other specific binding molecules such as boronic acid for binding and sensing glucose. Such a functionalized nanopipette is comprised in an electrical sensor that detects when the nanopipette selectively and reversibly binds ions or small molecules. Also disclosed is a nanoreactor, comprising a nanopipette, for controlling precipitation in aqueous solutions by voltage-directed ion migration, wherein ions may be directed out of the interior bore by a repulsing charge in the bore.

This application relates to a sample analyzing apparatus. In one aspect, the apparatus includes a base, a connector arranged at an end of the base, and a temperature controlling member mounted on the base and configured to adjust a temperature of the connector. The apparatus may also include a controller configured to adjust heat generation of the temperature controlling member to adjust a bonding force of a pipette tip attached to a surface of the connector.

A liquid is efficiently suctioned and discharged from and to a container formed by a plurality of aligned storing portions for storing the liquid, using a plurality of nozzles. Provided is a liquid suction/discharge device including a container support device for supporting a culture container formed by a plurality of aligned storing portions, and a nozzle support device for supporting a plurality of nozzles in a state in which distal ends of the nozzles are directed downward. The nozzle support device includes a nozzle support member that swingably supports the plurality of nozzles using prescribed parts as support points, and the liquid suction/discharge device further includes a nozzle inclination device for causing each of the nozzles to be inclined with respect to the nozzle support member.

A sample vessel includes a biological sample container and a sample stabilizer container. The biological sample container is configured to receive a biological sample and to store the biological sample. The sample stabilizer container is configured to contain a stabilizer associated with the biological sample. The sample stabilizer container is assembled from a stabilizer vial, an adaptor, and a fluid channel. The stabilizer vial is configured to store an amount of the stabilizer. The adaptor is configured to secure the biological sample container and the stabilizer vial such that the biological sample container and the stabilizer vial form the sample vessel. The fluid channel extends through the adaptor from the stabilizer vial to the biological sample container, the biological sample moving from the biological sample container into the stabilizer vial through the fluid channel.

In order to facilitate disassembly of the fluid dispensing unit (4), the latter has the covering cap (17) with which at least one sealing means (18) located in the head part (12) of the fluid dispensing unit (4) can be fixed in its use position. In order to release the covering cap (17) from the head part (12), said covering cap is rotatable relative to the head part (12). A releasable snap connection (19) is provided between the covering cap (17) and the head part (12), said snap connection being formed by at least one latching projection (20) and/or at least one latching depression (21), wherein at least one oblique surface (22) is formed on the latching projection (20) and/or on the latching depression (21), said surface being oriented in such a manner that the snap connection (19) can be released by rotation of the covering cap (17) relative to the head part (12) (FIG. 3).