Embodiments described herein relate to an apparatus for positioning and securing an excised biological tissue specimen for imaging and analysis. In some embodiments, an apparatus includes a sample bag defining an inner volume configured to receive a biological tissue sample, and a sealing member coupled to the sample bag. An imaging window is disposed and configured to be placed in contact with at least a portion of the biological tissue sample, and a positioning member is coupled to the imaging window and is configured to be disposed against the sealing member to substantially seal the inner volume. The positioning member includes a vacuum port disposed and configured to be aligned with a vacuum source to withdraw air from the inner volume of the sample bag.

The present invention provides a test device. The device includes a testing element and a housing accommodating the testing element; the housing is formed by folding a card which is made of a paper material. The testing element is located in the housing, and the housing is allowed to be in different change states to achieve the detection or assay of an analyte in a sample.

An apparatus for preparing a reagent solution includes an enclosure and a container disposed within the enclosure. The container defines an internal cavity having a compressible volume and defines a passage providing fluidic communication between the internal cavity and the exterior of the container. Optionally, a compressible member is disposed within the internal cavity. A reagent is disposed within the internal cavity.

A sampling apparatus can have an elongate tube and a liquid partitioning unit, first port can receive an incoming flow of test liquid and a second port may be coupled to the elongate tube. The liquid partitioning unit can combine the flow of test liquid with a plurality of partitioning elements to define a plurality of discrete liquid samples for movement along and storage in the elongate tube.

A computerized device provides microscopy and electrochemistry tests, performed in dual channels. The device can be brought to the field, for on-site testing with instant results. The dual channels include an imaging channel and a signal channel.

A carrier includes at least one take-up region based on a non-woven polyolefin containing dried-up capillary blood. The carrier is useful for semi-quantitatively, preferably quantitatively determining the concentration of an analyte in a blood sample. Further, a method is used for detecting an analyte in a blood sample and includes the steps of providing the carrier, applying a blood sample to the take-up region of the carrier, drying the carrier, contacting the carrier containing the dried-up capillary blood with a liquid which is suitable for taking up the analyte from the dried-up blood sample, and detecting the analyte in the liquid.

Methods, devices and systems for analyzing precious samples of cells, including single cells are provided. The methods, devices, and systems in various embodiments of the invention are used to assess genomic heterogeneity, which has been recognized as a central feature of many cancers and plays a critical role in disease initiation, progression, and response to treatment. The methods devices and systems are also used to analyze embryonic biopsies for preimplantation genetic diagnosis (PGD). In one embodiment, the devices, systems and methods provided herein allow for the construction of genomic and RNA-seq libraries without a pre-amplification step.

Embodiments described herein relate to an apparatus for positioning and securing an excised biological tissue specimen for imaging and analysis. In some embodiments, an apparatus includes a sample bag defining an inner volume configured to receive a biological tissue sample, and a sealing member coupled to the sample bag. An imaging window is disposed and configured to be placed in contact with at least a portion of the biological tissue sample, and a positioning member is coupled to the imaging window and is configured to be disposed against the sealing member to substantially seal the inner volume. The positioning member includes a vacuum port disposed and configured to be aligned with a vacuum source to withdraw air from the inner volume of the sample bag.

An apparatus configured for displacing fluid from a fluid container comprises first and second actuators configured to be movable together until the first actuator compresses a first part of the fluid container and then moveable independently until the second actuator compresses a second part of the fluid container. Fluid containers comprise a first vessel, a second vessel, and a sealing partition preventing fluid flow from the second vessel and further include a piercing point for piercing the sealing partition to permit fluid flow from the second vessel. A fluid container comprises a vessel configured to be collapsed to displace fluid from the vessel, a housing surrounding at least a portion of the vessel, and a floating compression plate movably disposed within the housing and configured to permit an external actuator to press the compression plate into the vessel to collapse the vessel and displace the fluid contents therefrom.

A sealed bag containing a reference fluid for the calibration and/or quality control of a creatine and/or creatinine sensor, the bag comprising: an inner polymer layer and an outer polymer layer; and an aluminium oxide gas barrier layer there between; and wherein the inner polymer layer is in contact with the reference fluid.