Methods, devices and systems for analyzing precious samples of cells, including single cells are provided. The methods, devices, and systems in various embodiments of the invention are used to assess genomic heterogeneity, which has been recognized as a central feature of many cancers and plays a critical role in disease initiation, progression, and response to treatment. The methods devices and systems are also used to analyze embryonic biopsies for preimplantation genetic diagnosis (PGD). In one embodiment, the devices, systems and methods provided herein allow for the construction of genomic and RNA-seq libraries without a pre-amplification step.

The present invention relates to a bioprocess bag 118 comprising a bag wall defining an enclosed volume for holding biomaterials. The bag wall comprises at least one inlet port 142 and at least one outlet port 146. The bioprocess bag 118 also comprises a tube structure 400 comprising a first opened-end proximate the bag wall and a second distal end, the tube extending into the enclosed volume, and the tube structure 400 comprising a reinforced portion 402 proximate the first opened-end.

The present disclosure relates to an immunoassay method for performing immunoassay by using a patch that contains antibodies. An immunoassay method according to an aspect of the present disclosure performs diagnosis by detecting a target protein from a sample to be diagnosed by using a patch which includes a mesh structural body forming micro-cavities and is configured to contain a liquid substance in the micro-cavities, and includes placing the sample to be diagnosed in a reaction region, and providing an antibodies that react specifically with a target protein to the reaction region by using a patch that contains the antibodies.

Computerized devices provide microscopy and electrochemistry tests, performed in dual channels. The devices can be brought to the field, for on-site testing with instant results. The dual channels include an imaging (optical or microscopic) channel and a signal channel. Microfluidic chips are disclosed for use with the microscopy channel optics.

A method and a device connects a partially flexible protective cover (2) sealed against the environment and forming a barrier between a contaminated area (12) and an uncontaminated area, to a partially flexible safety cover (20) by transferring the protective cover (2) out of the contaminated area (12) inverting the protective cover (2) over an opening such that its inside is turned out and then severing it from the safety cover (20) and closing the opening; or transferring the protective cover (2) from the contaminated area (12) by sheathing the protective cover (2) with the safety cover (20) as it is pulled through a passage and subsequently severing of both covers (2, 20) from the safety cover (20) and closing the sheathing; or pulling the protective cover (2) back into the contaminated area (12) and then sealing the ends shut to sever the safety cover (20) by forming a further sealed joint between adjacent film parts.

The invention discloses a highly integrated analyte detection system, including: a bottom case; a sensor structure, the sensor structure includes a sensor and a sensor base, the sensor includes a signal output end and a detection end, and at least two first electrical connection areas insulated from each other are provided on the surface of the signal output end; and a transmitter, the transmitter and the bottom case are fastened with each other, and the transmitter is provided with second electrical connection areas, which are insulated from each other, corresponding to the first electrical connection areas, each second electrical connection area is electrically connected to the corresponding first electrical connection area. Such a design reduces the height of the sensor structure, making the overall structure of the detection system more compact, as a result, reducing the volume and enhancing the user experience.

The invention discloses a micro-analyte detection device, which comprises a bottom case, the bottom board of the bottom case is provided with a mounting hole; a sensor structure, the sensor structure includes a sensor and a sensor base, and the sensor includes a signal output end and a detection end, and a transmitter, the transmitter includes a transmitter housing and an electronic device, the electronic device is provided with an electrical connection area, when the transmitter is installed in the working position, the electrical connection area is electrically connected with the signal output end. This device effectively reduces the overall thickness of the analyte detection device and enhances the user experience.

A sensing device includes a base, a probe structure and a transmitter structure. The base is provided with a first fastener part. The probe structure includes a second fastener part, a probe and a connection area. The transmitter structure includes a transmitter housing and a transmitter disposed inside the transmitter housing, the transmitter housing is provided with a connection hole, the shape of which matches the shape of the probe structure, and when the transmitter structure is mounted to the base, the probe structure is located in the connection hole, and the transmitter is electrically connected to the connection area to receive the signal generated by the probe.

An in-situ fecal specimen sampling device for stool tests, comprising: a sampling tube of a tube-like structure comprising an bottom with an opening; a sampling structure disposed inside the sampling tube is attached to the bottom of the sampling tube, and is an tube-like structure with a closed top end, an bottom end with opening and an stretchable soft body, which can insert a finger from the opening of the bottom outside the sampling tube and push forward and stretch the closed top end to beyond the sampling tube. The sample provider is able to collect the sample by placing the sampling structure onto the stool or inside the anus through the finger operated sampling structure by himself. All of the process can be finished during defecation process in-situ.

A modular aircraft galley insert for performing thermal cycling for PCR testing includes a housing having a sample module for receiving a sample to be tested, a thermal module thermally connected to the sample module for cycling temperatures of the sample to be tested, a power module for providing power to the thermal module, a detector module configured to analyze the sample and connected to receive power from the power module, and a connectivity module for communicating results of a test from the detector module to a remote location with respect to the housing.