A permanent-magnet piston subassembly (10) for a pipetting apparatus, the piston subassembly (10) extending along a piston axis (K) and comprising a plurality of permanent-magnet arrangements (14a to 14m) that are arranged one behind another along the piston axis (K) with alternatingly opposite polarization directions in such a way that for each two permanent-magnet arrangements (14i, 14j) directly successive along the piston axis, it is the case that magnetic poles located closest to one another along the piston axis (K), of different successive permanent-magnetic arrangements (14a to 14m), are like poles, is characterized in that the piston subassembly (10) encompasses a sheath tube (12), extending along the piston axis (K) constituting a tube axis (H), in which the plurality of permanent-magnet arrangements (14a to 14m) are received.

Provided are a compact mixing system capable of reducing a use amount of a mixing agent and reducing a volume of a utility that supplies the mixing agent, and a measurement system using the mixing system. The mixing system includes: a mixing agent discharge nozzle through which a mixing agent to be mixed with a sample is to be discharged; and a movable mechanism configured to adjust a gap between the mixing agent discharge nozzle and a sample collection port that opens to an inside of a sample tube through which the sample is to flow so as to collect the sample.

The present invention provides an analytical system comprising a sample management module. A pressure delivery assembly is configured to compress and deform a mixing chamber containing a sample preparation, and simultaneously open a plug of the mixing chamber to release the sample preparation. The system can be manufactured as a sample box combinable to a detector box, and is particularly convenient for patients to use at home, for example, screening colorectal cancer with their fecal sample.

An analytical device comprising A) A first sealed compartment comprising an extraction solvent or extraction reagent within the device wherein the first compartment comprises a seal over an opening, B) A second compartment comprising an opening, wherein the opening of the second compartment is aligned with the opening of the first compartment, C) A reaction region comprising one or more reaction reagents wherein at least a portion of the reaction region is located below at least a portion of the first or second compartment and is configured to receive liquid flowing from the first or second compartment. D) A first fluid passage connecting the first or second compartment to the reaction region wherein the first fluid passage comprises a first surface energy gradient coating, E) A detection region comprising one or more detection agents wherein the detection region is located downstream of the reaction region and is configured to receive liquid flowing from the reaction region. F) A third compartment having an opening wherein at least a portion of the third compartment is located above the reaction region, and
wherein the openings of the first, second, and third compartments are configured to receive at least a portion of a sampler.

A reagent pack changer includes a reagent pack input device, a reagent pack storage compartment, a reagent pack storage carousel disposed within the storage compartment, and a rotary distributor. The input device includes a reagent pack input carousel rotatable about an axis of rotation, with reagent pack stations for holding reagent packs disposed around the axis of rotation of the carousel. The reagent pack storage carousel is rotatable about an axis of rotation with reagent pack stations for holding reagent packs disposed around the axis of rotation. The rotary distributor is configured to move a reagent pack between the reagent pack input carousel and the reagent pack storage carousel.

The present invention provides for a fluid transfer device for interconnecting vessels, the fluid transfer device comprising a main body with a first body part providing a first hollow interior merging into a first open end for receiving a fluid obtaining vessel, and a second body part providing a second hollow interior merging into a second open end for receiving a fluid supplying vessel, a connection assembly with a double-ended cannula for connecting the first hollow interior with the second hollow interior, and a first encasing member encasing a first cannula part arranged within the first hollow interior, and an actuating member provided inside the first hollow interior, wherein the actuating member is movably arranged along a longitudinal axis of the first body part, and wherein the actuating member is in contact with the first encasing member for piercing the first encasing member by the cannula during a movement of the actuating member towards the second body part. Furthermore, the present invention provides for the use of such fluid transfer device for venting a fluid supplying vessel and/or interconnecting vessels, as well as for a respective method.

A diagnostic system is configured to perform first and second, different nucleic acid amplification reactions. The system includes a bulk reagent container compartment configured to store first bulk reagent container containing a first bulk reagent for performing sample preparation processes with a first subset and a second subset of a plurality of samples and a second bulk reagent container containing a second bulk reagent for performing the first nucleic acid amplification reaction. The system includes a unit-dose reagent compartment storing a unit-dose reagent pack including unit-dose reagents for performing the second nucleic acid amplification reaction. The system is configured to perform the sample preparation process using the first bulk reagent on the first and second subsets of the samples, perform the first nucleic acid amplification reaction using the second bulk reagent on the first subset of the samples, and perform the second nucleic acid amplification reaction using the unit-dose reagents on the second subset of the samples.

The automatic analysis system comprise a storage device configured to store a plurality of reaction cuvettes intended to contain biological liquids samples to analyze; at least one samples processing station, comprising at least one receiving cavity which is downwardly open and configured to receive and house at least partially one reaction cuvette; and a displacement device configured to displace a reaction cuvette, the displacement device being further configured to unload a reaction cuvette out of the storage device and to load and unload a reaction cuvette into and out of the at least one receiving cavity of the at least one samples processing station via the respective introduction opening.

To introduce a reagent with a small amount of residual liquid and enable a fluidic manipulation by deformation of an elastic film, a sealed type of sample processing device is configured with a reagent storage including a joint portion which joins an upper film and a lower film at a periphery of a storage space which stores a reagent between both films, an analysis chip including a lower surface fluid channel through which a liquid flows on a lower surface side and an upper surface fluid channel through which the liquid flows on an upper surface side, and an elastic film which seals the lower surface side of the analysis chip. A portion of the lower film is joined to the upper surface side of the analysis chip, a removed portion, in which the lower film is partially removed, is in an upper part of the upper surface fluid channel.

A cartridge covering element for sealing off a microfluidic cartridge comprising: at least one stratified adhesive mass, the stratified adhesive mass being UV-activatable to induce curing and being tacky at room temperature prior to and after activation until expiry of an open time.