The present invention provides a biological sample holder and handler system for cell-based liquid biopsies. The system is useful for performing diagnostic assays, based on a simple blood sample. For example, the system is useful for delivering precision cancer diagnoses that improve patient outcomes by optimizing treatment options, monitoring therapy efficacy, characterizing metastasis and assessing treatment toxicity

A holder for a single capillary tube includes: an elongated carrier which at one end thereof has two clamping jaws at a distance from each other for receiving one end of the capillary tube and an other end thereof a handle with an elongated planar area, the handle being connected to the elongated carrier in one piece. The elongated carrier includes a planar area and is thinner than a diameter of a capillary rod to be held, and at one end the elongated carrier has an elongated slit forming two opposite arms including clamping jaws. A planar area of the handle includes a marking field for applying information. The marking field is arranged on one side or on both sides of the elongated carrier.

The combined capillary electrophoresis electrospray mass spectrometry apparatus has a circuit to handle excess current allows separations under a wide range of electrophoretic conditions. The apparatus includes an electrospray with an emitter and an electrospray interface connected with a separation capillary configured to transport a sample with an injection end and a distal end. The injection end of the separation capillary is inserted into a reservoir containing a background electrolyte and the distal end is threaded within the electrospray interface and sized and shaped to mate with the electrospray interface. A power supply is electrically connected to the injection end and an amplifier at least one first diode positioned between the amplifier and the distal end allows current to flow to the distal end only. A second diode positioned between the distal end and a ground configured to allow current flow to the ground.

A capillary tube holder is provided for holding a capillary tube. The capillary tube holder includes a holder insert and a holder base. The holder insert includes a capillary groove configured for receiving the capillary tube. The holder base is configured for slidably receiving and retaining the holder insert therein.

An aliquoting and freezing storage device comprises a test tube and at least one capillary tube. The capillary tube is inserted into a test tube, and the capillary tube is provided with an inner long hole which penetrates throughly. The device utilizes the capillarity to quickly and easily store biological samples in the capillary tubes. When needed, the operator only needs to remove one or several of the tubes, without affecting the remaining biological samples, so as to avoid repeated freezing and thawing of biological samples.

The present disclosure describes a cryogenic vessel or holder designed to retain biological specimens, such as embryos or unfertilized eggs. The holder is insulated to reduce the rate of warming of the biological specimens, can hold numerous biological specimens snuggly to alleviate damage by jarring, and has an inner cavity that receives cryogen to keep the biological specimens immersed in cryogen during shipping. The design allows for safer shipping and handling of the biological specimens with less risk of damage. The design can also be utilized as a long-term sample holding and storage device.

A sampling device comprises a handle and a collector. The collector is connected to the handle. The collector has a capillary function and is able to automatically suction a liquid reagent or sample. The sampling device is able to suction a required amount of the reagent or sample quickly, conveniently and quantitatively. The sampling device can be product conveniently, and may achieve micro-quantitative sampling. The reagent is stored in the collector of the sampling device in the form of a dry powder, which may achieve the individual packaging of the detection reagent.