Systems and methods for conducting surface-mediated chemical and/or biochemical reactions within an enclosed chamber are disclosed. Systems and methods of the present disclosure may be used in conducting hybridization reactions of biopolymers. In some examples, an improved method for mixing thin films of solutions in a hybridization chamber includes altering the direction of mixing at least once over the course of a reaction. In some examples, an improved method for mixing thin films of solutions in a hybridization chamber includes altering the speed of mixing at least once over the course of a reaction. In some examples, an improved method for mixing thin films of solutions in a hybridization chamber includes altering the speed of mixing and the direction of mixing at least once over the course of a reaction.

A nucleic acid extraction system, comprising: a nucleic acid extraction plate, and a pipetting device and positive pressure device that are arranged side by side, the pipetting device comprising: an infusion device, an infusion device mounting frame, an infusion device driving unit, and a plurality of infusion units, each of the infusion units comprising: a reagent supply device and a reagent flow controller; the positive pressure device comprises: a plug, an air pipe, a positive pressure provider and a positive pressure driving device. The nucleic acid extraction system is highly efficiency and low-cost when extracting nucleic acid.

A bench top incubator is described. The bench top incubator includes a first tray stack designed to retain microscope slides in a plurality of slide trays and a second tray stack designed to retain multi-well plates in a plurality of plate trays. The incubator is relatively simple and small in design and can be conveniently located to carry out temperature processing of biological samples such as fixed cells and tissues, biological fluids, and so forth.

This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.

An assay plate is provided. The assay plate has a body with a plurality of reservoirs formed therein. The reservoirs are shaped and aligned in the body in an orientation to induce drainage of fluids contained therein in a desired direction. A plate array and a funnel array forming an assembly for pooling of samples contained in the assay plate is also provided.

The present invention relates to methods, devices and systems for associating consumable data with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system adjusts one or more steps of an assay protocol based on consumable data specific for that consumable. Various types of consumable data are described, as well as methods of using such data in the conduct of an assay by an assay system. The present invention also relates to consumables (e.g., kits and reagent containers), software, data deployable bundles, computer-readable media, loading carts, instruments, systems, and methods, for performing automated biological assays.

The invention relates to a temperature-control element (4) for a multiwell plate (1), which comprises a plurality of cavities (2) arranged in rows and columns for freezing and/or thawing biological samples. The temperature-control element (4) comprises a base body (6) which is made of a thermally conductive material and is flown through by a temperature-control fluid; and a plurality of protruding temperature-control fingers (5) arranged in rows and columns on an upper side of the base body (6), which are connected in a thermally conductive manner to the base body (6), wherein a grid spacing of the temperature control fingers (5) corresponds to a grid spacing of the cavities (2) of the multiwell plate (1). The invention further relates to a device and method for freezing biological samples, in particular for cryopreservation, and/or thawing biological samples, in particular a cryopreserved sample.

The instant disclosure provides methods of multi-assay processing and multi-assay analysis. Such multi-assay processing and analysis pertain to automated detection of target nucleic acids, e.g., as performed in the clinical setting for diagnostic purposes. Also provided are common assay timing protocols derived from a variety of individual nucleic acid amplification and analysis protocols and modified to prevent resource contention. The instant disclosure also provides systems and devices for practicing the methods as described herein.

A system (100) for storing, identifying and localizing supports (20, 21) for tissue samples embedded in paraffin, comprising—a plurality of supports (20, 21), wherein each one is provided with a respective RFID tag (201), said supports (20, 21) being each a histology cassette (20) configured to contain a tissue sample embedded in paraffin, or a slide (21); —a plurality of trays (1), wherein each tray (1) is provided with a respective RFID tag (101), and is configured to contain a plurality of said supports (20, 21), ach tray (1) being provided with a plurality of seats (11), each seat (11) being configured to receive a respective support (20, 21) and each support (20, 21) being adapted to be arranged at a respective seat (11); —at least one component (3) provided with a plurality of RFID antennas (10, 31), said plurality of RFID antennas (10, 31) comprising an RFID antenna (10) for reading the RFID tag (101) of a tray (1) of said plurality of trays, and RFID antennas (31) for reading the RFID tags (201) of the supports (20, 21); —at least one RFID interrogator (4); —one or more demultiplexers (5), by means of which the RFID interrogator (4) may be connected to each RFID antenna (10, 31) of said plurality of RFID antennas (10, 31), said one or more demultiplexers (5) being configured to sequentially activate a unique signal transmission line for each RFID antenna (10, 31) of said plurality of RFID antennas (10, 31); —an electronic control unit (6), configured to synchronize said one or more demultiplexers (5) and said at least one RFID interrogator (4) with one another, to sequentially read the RFID tags (210) of the supports (20, 21) and the RFID tag (101) of a tray (1) of said plurality of trays by means of one RFID antenna (10, 31) at a time, of said plurality of RFID antennas (10, 31).

The invention is a device for quantitatively collecting pooled samples from multiwell plates.