In a pipette tip that is open at opposite distal and proximal ends, a glass tube has a first end adjacent to the distal end, a second end adjacent to the proximal end, and a first through hole extending therethrough from the first end to the second end. A connecting member has a second through hole with the glass tube inserted therein. The glass tube is at least partially inserted in the second through hole on one side adjacent to the second end, and is entirely located outside the second through hole on the other side adjacent to the first end. A diameter of an end portion of the connecting member opposite the distal end is greater than a diameter of the distal end of the pipette tip, and the connecting member is made of resin.

A digital dispense apparatus includes at least one fluid dispense device, at least one reservoir fluidically connected to the at least one fluid dispense device, a monolithic carrier structure carrying the at least one fluid dispense device and reservoir, the monolithic carrier forming fluid routing between the reservoir and the fluid dispense device.

This disclosure provides a gene chip comprising a substrate and at least one positioning device fixed on an upper surface of the substrate, wherein the at least one positioning device is provided with a receiving cavity for receiving a bead, the receiving cavity being arranged on a surface of the at least one positioning device facing away from the substrate, and a cross-sectional area of the receiving cavity is gradually decreased in a direction toward the upper surface of the substrate. This disclosure further provides a gene detection device comprising the gene chip.

A system for partitioning a liquid sample, the system including: an ejection device, the ejection device including an array of nozzles, wherein adjacent nozzles are separated by a constant distance in a first axis; and a microfluidics device including: a plurality of intake ports to receive a deposited droplet, wherein pairs of intake ports are separated by the same constant distance in the same first axis such that adjacent nozzles can simultaneously eject droplets to different intake ports.

A sample loading bottom plate (300,600, 810, 820, 831) and an immunochromatography detection apparatus (10) containing the sample loading bottom plate (300, 600, 810, 820, 831). During design of the sample loading bottom plate (300, 600, 810, 820, 831), a sample loading portion (310, 833) having a multistage-step structure is additionally provided on a sample loading region and comprises multistage steps having different heights, wherein a base surface (311) is used for carrying a sample solution. After a cover plate (100, 500, 834) is covered, the sample solution falls on the base surface (311) and then flows upwardly, and by means of the flow-intercepting and buffering effects of the multistage-step structure, the sample solution which finally flows to a top surface (342, 642) of the highest step (340, 640) can basically flow to sample loading regions of immunochromatography detection members synchronously, so that the multiple immunochromatography detection members can basically receive the sample solution synchronously, the unifying problem of time and sample horizontal lines is solved, and the test accuracy is high; moreover, only one-time sample adding is needed, the detection efficiency is high, and the risk of errors is low. During detection, the immunochromatography detection members perform detection individually and perform sample loading synchronously without mutual interference, and the accuracy of a detection result is high.

A cover assembly may include a tray assembly frame, a first cover supported by the tray assembly frame, the first cover extending in a first plane and defining one or more first openings; a second cover supported by the tray assembly frame, the second cover extending in a second plane and defining one or more second openings, wherein the first and second planes are different planes, and wherein the second cover is disposed above the first cover. The cover assembly may include one or more tray holders, each tray holder being configured to hold at least one tray in an upright orientation, wherein each tray holder is moveable between an open position and a closed position, the tray holders being accessible for loading or removing the trays in the open position, and the tray holders being positioned beneath the first and second covers in the closed position.

A tray for transferring a plurality of solid reagents to a multi-well cartridge, the tray including a top surface having a plurality of depressions formed therein, each depression being configured to receive and hold a single one of the solid reagents, and a barrier wall projecting above and substantially surrounding the top surface, where the barrier wall is discontinuous at a first end of the tray.

Multi-well collapsible basket arrays and methods for their use with high throughput culture and histology analysis of spheroids and organoids. Such a collapsible basket array includes a collapsible cellular array structure having multiple cells and connectors that interconnect adjacent pairs of the cells to cause the collapsible cellular array structure to collapse from an expanded configuration to a collapsed configuration in which the connectors are partially wrapped around perimeters or circumferences of the cells, whereby the collapsible cellular array structure is expandable to acquire an expanded configuration capable of individually aligning the cells thereof with wells of a well plate. The collapsible basket array further includes inserts individually mountable to the cells of the collapsible cellular array structure, with each insert including a permeable basket with pores sized to retain spheroids or organoids within the basket.

A system, method, and platform for target detection, the system including: a base substrate; a set of sample processing regions defined at a broad surface of the substrate, wherein each of the set of sample processing regions includes: a set of microwell subarrays arranged in a gradient between an upstream end and a downstream end of each respective sample processing region, and a boundary separating each respective sample processing region from adjacent sample processing regions; and a cover substrate configured to mate with the base substrate in a coupled mode, the cover substrate comprising a network of venting channels aligned with the set of sample processing regions upon mating the base substrate with the cover substrate in the coupled mode, the network of venting channels providing gas exchange between the base substrate and an environment surrounding the microwell assembly. The invention(s) can be used for MPN assays.

Fluidic device includes a manifold body having first and second body sides. The first body side has receiving ports forming a port array that defines a reaction region. The second body side has open-sided recesses forming reaction chambers when the fluidic device is mounted onto a sample substrate. The reaction chambers form a chamber array that defines a fluid-delivery region. The reaction region is greater than the fluid-delivery region. The manifold body also includes vent openings that open to an exterior. The fluidic device also includes upstream channels extending through the manifold body. Each of the upstream channels fluidly couples a corresponding receiving port of the port array to a corresponding reaction chamber of the chamber array. The fluidic device also includes venting channels extending through the manifold body. Each of the venting channels fluidly couples a corresponding reaction chamber of the chamber array to a corresponding vent opening.