The present invention provides devices, systems, and methods for rapid and easy-to-use in sample thermal cycling or temperature changes for the facilitation of reactions such as but not limited to PCR.

Operability, accuracy, and safety when fitting a glass-made pipette tip to a pipette are improved. A pipette tip fitting adapter includes a hollow body having one end portion configured to serve as a tip inserting portion into which a pipette tip is inserted, and the other end portion configured to serve as a pipette inserting portion into which a pipette is inserted, and at an opening side of an inner circumferential surface of the tip inserting portion, seal portions projecting inward are formed in a circumferential direction. Accordingly, a pipette tip that is long and heavy like a glass tip can be held.

The invention concerns a frame (1) for holding a plurality of filtration assemblies (100) and a testing unit (10) for microbiological testing. The frame (1) for holding the plurality of filtration assemblies (100) comprises an array of supports (5) each configured to receive and support one of the filtration assemblies (100) on a common support plane (2), and connection means (6) provided on the periphery (7) of the frame (1) and configured to releasably connect, by a form-locking engagement, a further frame (1) such that the common support planes (2) of the connected frames (1) are contiguous. Further, the testing unit (10) comprises at least one frame (1) packed in a bag (20) in pre-sterilized condition.

Technology for a biochip pillar structure is disclosed. According to an embodiment of the present disclosure, the biochip pillar structure includes: a pillar structure including a plate-shaped first substrate portion, and pillar portions protruding from a surface of the first substrate portion; and a well structure including a plate-shaped second substrate portion, and well portions formed in a surface of the second substrate portion and having a predetermined depth to respectively receive the pillar portions of the pillar structure, wherein the well portions have a diameter within a range of 800 m to 1500 m, and the pillar portions configured to be inserted into the well portions have a diameter of which the ratio to the diameter of the well portions ranges from 0.3 to 0.58, thereby providing a high-density biochip and preventing bubbling in an aqueous liquid contained in the well portions when the pillar portions are inserted.

The invention relates to a device (1), a method, and a kit for analysing liquid samples. The device (1) comprises a sample layer (111) having a plurality of liquid permeable test sites (112) separated by a liquid impermeable barrier region (113), and an inlet part (2) comprising a plurality of inlet channels (211), which lead to respective test sites (112) of the sample layer (111), such that a flow connection between said inlet channels (211) and said respective test sites (112) is established or can be established, wherein said inlet channels (211) comprise first openings (218) and second openings (219), wherein a second surface area defined by the positions of said second openings (219) is smaller than a first surface area defined by the positions of said first openings (218) The invention further relates to a method for functionalizing a sample layer (111).

The present invention relates to systems that utilize a combination of immunoassay and magnetic immunoassay techniques to detect an analyte within an extended range of specified concentrations. In particular, a device includes a first electrochemical sensor positioned within a conduit adjacent to a second electrochemical sensor and spaced apart from one another at a predetermined distance. The first electrochemical sensor includes an immobilized layer of antibodies. The second electrochemical sensor includes a magnetic field disposed locally around the second electrochemical sensor, and the magnetic field is configured to attract magnetic beads onto a surface of the second electrochemical sensor. The device further includes a scavenging electrode positioned between the first electrochemical sensor and the second electrochemical sensor. The scavenging electrode is configured to prevent crosstalk between the first electrochemical immunosensor and the second electrical immunosensor.

Among other things, the present invention is related to devices and methods of performing biological and chemical assays, particularly an easy sample manipulation and/or a rapid change or a rapid thermal cycling of a sample temperature is needed (e.g. Polymerase Chain Reaction (PCR) for amplifying nucleic acids).

The present invention provides devices, systems, and methods for rapid and easy-to-use in sample thermal cycling or temperature changes for the facilitation of reactions such as but not limited to PCR.

Disclosed herein are a device and method for the easy removal of selected individual wells, selected groups/strips of wells, or all strips of wells quickly and safely from a well strip plate. A well strip extractor press may include a manually pivotable well strip plate carrier having an open bottom, and an adjustable well strip extractor assembly having multiple press arms positioned to engage the bottom of a well strip plate positioned in the well strip plate carrier. A user may manually position a selection of press arms to align with those well strips that the user wishes to remove from the well strip plate. The user may lower the plate carrier into a frame assembly that pivotably mounts the press arms, causing the selected well strips that are to be dislodged from the well strip plate to engage individual extractor pins on the selected press arms, in turn causing those extractor pins to push the bottom portions of the selected well strips upward so as to at least partially dislodge from their seating within the strip well plate. Thereafter, a user may slide the strip well plate out from the plate carrier and remove the selected well strips from the well strip plate with ease.

Systems and methods for handling a variety of sample and preparatory fluids in a rack specifically configured for compatibility with predetermined liquid handlers such as automated pipettors or multi-channel manual pipettors and set up for magnetic based sample preparation. The rack can hold all of the necessary sample and reagent vials, and present them to the pipettor in some embodiments in a way that allows for parallel operation. The rack includes slidable magnets that in some embodiments are actuatable directly by the pipettor, eliminating a layer of complexity. Combined with a suitable pipettor the magnet enabled rack supports a multistep magnetic based sample preparation capability in a high throughput manner at one station that enhances sample purity throughout magnetic separation processes.