Pipette tip couplers, pipette tips, coupler and tip combinations, and methods for coupling and decoupling a pipette tip to or from an expanding mandrel pipette tip coupler mounted on a pipette device. The pipette tip couplers include circumferentially spaced apart segments for engaging an interior surface of a pipette tip, an annular base disposed below the segments, a distal elastomeric element disposed around a distal stem portion for sealing against the interior surface of the pipette tip, upwardly extending circumferentially spaced apart arms each supporting a different segment, and a stop disk for abutting a stop shoulder in a pipette tip. The pipette tips include a groove in a first cylindrical section, a second cylindrical section, a pipette tip stop shoulder surface, a third cylindrical section, and a sealing seat surface.

Pipette tip couplers, pipette tips, coupler and tip combinations, and methods for coupling and decoupling a pipette tip to or from, respectively, a pipette tip coupler mounted on a pipette device. The pipette tip couplers include an elastomeric element, an annular crown shaped raceway, and a coupler stop shoulder surface. The pipette tips include a groove in a first cylindrical section, a second cylindrical section, a tip stop shoulder surface at the interface of the first and second cylindrical sections, a third cylindrical section, a sealing seat surface at the interface of the second and third cylindrical sections, and a fourth section adjacent to the third cylindrical section. When the pipette tip is mounted on the pipette tip coupler, the annular crown shaped raceway abuts the tip groove, the coupler stop shoulder surface abuts the tip stop shoulder surface, and the elastomeric element abuts the sealing seat surface.

Multi-well collapsible basket arrays and methods for their use with high throughput culture and histology analysis of spheroids and organoids. Such a collapsible basket array includes a collapsible cellular array structure having multiple cells and connectors that interconnect adjacent pairs of the cells to cause the collapsible cellular array structure to collapse from an expanded configuration to a collapsed configuration in which the connectors are partially wrapped around perimeters or circumferences of the cells, whereby the collapsible cellular array structure is expandable to acquire an expanded configuration capable of individually aligning the cells thereof with wells of a well plate. The collapsible basket array further includes inserts individually mountable to the cells of the collapsible cellular array structure, with each insert including a permeable basket with pores sized to retain spheroids or organoids within the basket.

Pipette tip couplers, pipette tips, coupler and tip combinations, and methods for coupling and decoupling a pipette tip to or from a pipette tip coupler mounted on a pipette device. The pipette tip couplers include a proximal elastomeric element, a distal elastomeric element, and a coupler stop shoulder surface between the elastomeric elements. The pipette tips include a groove in a first cylindrical section, a second cylindrical section, a tip stop shoulder surface at the interface of the first and second cylindrical sections, a third cylindrical section distal to the second cylindrical section, and a sealing seat surface at the interface of the second and third cylindrical sections. When the pipette tip is mounted on the pipette tip coupler, the proximal elastomeric element abuts the tip groove, the coupler stop shoulder surface abuts the tip stop shoulder surface, and the distal elastomeric element abuts the sealing seat surface.

Pipette tip couplers, pipette tips, coupler and tip combinations, and methods for coupling and decoupling a pipette tip to or from, respectively, a pipette tip coupler mounted on a pipette device. The pipette tip couplers include an elastomeric element, a discrete segment assembly, and a coupler stop shoulder surface. The pipette tips include a groove in a first cylindrical section, a second cylindrical section, a tip stop shoulder surface at the interface of the first and second cylindrical sections, a third cylindrical section, a sealing seat surface at the interface of the second and third cylindrical sections, and a fourth section adjacent to the third cylindrical section. When the pipette tip is mounted on the pipette tip coupler, the discrete segment assembly abuts the tip groove, the coupler stop shoulder surface abuts the tip stop shoulder surface, and the elastomeric element abuts the sealing seat surface.

The present invention relates to a holding structure for simultaneously holding a plurality of containers for substances for pharmaceutical, medical or cosmetic applications or of devices having such containers, having a plurality of receptacles. The receptacles are arranged in a regular arrangement and are formed by in each case peripherally formed side walls. The receptacles have in each case one or two widened clearances having a dimension which is greater than the width of a gap between the containers received in the receptacles and side walls of the receptacles in the regions other than the widened clearances. The widened clearances additionally make available space for access to containers or devices which are received in the receptacles for handling thereof.

This disclosure provides a gene chip comprising a substrate and at least one positioning device fixed on an upper surface of the substrate, wherein the at least one positioning device is provided with a receiving cavity for receiving a bead, the receiving cavity being arranged on a surface of the at least one positioning device facing away from the substrate, and a cross-sectional area of the receiving cavity is gradually decreased in a direction toward the upper surface of the substrate. This disclosure further provides a gene detection device comprising the gene chip.

Pipette assembly comprising a pipette device, a pipette tip, and an expanding mandrel collet coupling device coupling the tip to the pipette device, the coupling device comprising a central body, a spacer with cogs circumscribing a central body, an expanding mandrel collet circumscribing the spacer having an annular base and circumferentially spaced apart upwardly extending collet arms wherein the cogs protrude through spaces between the arms, and an elastomeric element circumscribing the central body. The collet arms are attached to the annular base and configured to expand between a first and a second greater circumference for engaging a first interior working surface of the tip in concurrence with the elastomeric element sealing against a second interior working surface below the first surface and in concurrence with an abutment between the cogs and a stepped interior shoulder of the pipette tip disposed between the first and second working surfaces.

The invention is directed to a pipette assembly that includes a pipette device, a pipette tip, and an expanding mandrel collet coupling device coupling the tip to the pipette device, the coupling device comprising a central body, a spacer with cogs circumscribing a central body, an expanding mandrel collet circumscribing the spacer having an annular base and circumferentially spaced apart upwardly extending collet arms wherein the cogs protrude through spaces between the arms, and an elastomeric element circumscribing the central body. The collet arms are attached to the annular base and configured to expand between a first and a second greater circumference for engaging a first interior working surface of the tip in concurrence with the elastomeric element sealing against a second interior working surface below the first surface and in concurrence with an abutment between the cogs and a stepped interior shoulder of the pipette tip disposed between the first and second working surfaces.

Operability, accuracy, and safety when fitting a glass-made pipette tip to a pipette are improved. A pipette tip fitting adapter includes a hollow body having one end portion configured to serve as a tip inserting portion into which a pipette tip is inserted, and the other end portion configured to serve as a pipette inserting portion into which a pipette is inserted, and at an opening side of an inner circumferential surface of the tip inserting portion, seal portions projecting inward are formed in a circumferential direction. Accordingly, a pipette tip that is long and heavy like a glass tip can be held.