Provided is a heating mechanism for a biochemical reaction device, including: a heat-conducting body including: at least one accommodating groove each including a chamber and an opening communicating with the chamber; a clamping hole, in communication with the opening and for inserting a reaction tube; and at least one heat-conducting block, movably disposed in the chamber and having one end connected with an elastic element and another opposite end provided with an abutting portion, the elastic element enabling the abutting portion of the heat-conducting block to protrude from the opening and locate in the clamping hole; and a temperature control element connected to the heat-conducting body for heating and regulating a temperature of the heat-conducting block. The heat-conducting blocks of the heating mechanism can be in direct and assured contact with the reaction tube for conducting heat, so that the solution in the reaction tube can easily and assuredly reach a preset temperature, thereby achieving a consistent reaction condition and increasing the accuracy of the reaction result.

A column tube holder includes: a first side rail extending vertically; a second side rail extending vertically; a first shelf extending horizontally between the first side rail and the second side rail; a second shelf extending horizontally between the first side rail and the second side rail, the second shelf disposed below the first shelf; and a third shelf extending horizontally between the first side rail and the second side rail, the third shelf disposed below the second shelf. The column tube holder is composed of a conductive material, an anti-static material, and/or a static dissipative material.

A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lends can be a bi-convex lens.

An adapter assembly for receiving a capillary includes a passage, into which the capillary is or can be received. The adapter assembly has an adapter cone which is configured for being received in or on a correspondingly configured counter cone. The adapter cone, at least over a section for bringing the adapter cone into contact with the counter cone, includes an elastic material that is more elastic than the material of the counter cone. The invention further relates to a counterpart for connecting to the adapter, to an apparatus and to a method for automatically exchanging capillaries.

High-throughput digital microfluidic (DMF) systems and methods (including devices, systems, cartridges, DMF apparatuses, etc.), are described herein. The systems, apparatuses and methods integrate liquid handling with the DMF apparatuses, providing flexible and efficient sample reactions and sample preparation. These systems, apparatuses and methods may be used with a variety of cartridge configurations and sizes.

The technology relates in part to a segmented pipette tip adapter that includes a plurality of plate segments and a junction between adjacent plate segments. Each of the plate segments often includes a proximal surface, a distal surface, edges, one or more nozzles disposed on the proximal surface, and one or more tubular projections disposed on the distal surface. Each of the nozzles often includes a nozzle bore, each of the tubular projections often includes a tubular projection bore, each of the plate segments often includes a plate bore disposed at each of the nozzles, and each nozzle bore often is aligned with a tubular projection bore and a plate bore. Each junction often is between adjacent edges of a pair of adjacent plate segments.

This dispensing method includes a connection step for connecting a flange part (64) of a piston (65) and a drive member (50) that drives the piston (65), a first movement step for causing the drive member (50) to move to a first position so as to come into contact with the lower surface of the flange part (64), an intake step for raising the piston (65) to thereby take a liquid into a syringe (62) into which the piston (65) is inserted, a second movement step for causing the drive member (50) to move to a second position so as to come into contact with the upper surface of the flange part (64), a discharge step for lowering the piston (65) to thereby discharge the liquid inside the syringe (62), and a separation step for separating the flange part (64) and the drive member (50).

The present invention relates to methods, devices and systems for associating consumable data with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system adjusts one or more steps of an assay protocol based on consumable data specific for that consumable. Various types of consumable data are described, as well as methods of using such data in the conduct of an assay by an assay system. The present invention also relates to consumables (e.g., kits and reagent containers), software, data deployable bundles, computer-readable media, loading carts, instruments, systems, and methods, for performing automated biological assays.

The self-contained kit comprises methods for receiving and preparing the biological samples for the nucleic acid amplification and sensing the presence of the target assay. The kit consists of a self-heating pack to provide the heat for nucleic acid sample preparation and amplification processes. The change of the amplification is indicated through colorimetric or turbidity sensing and detected through a mobile phone camera and associated mobile application for photographic scanning of physical or chemical differences of the samples to produce the test results.

The invention relates to a system for automatic closure of sample vessels (PG), in particular of sample vessels (PG) with medical laboratory samples, with iii. a plurality of identically shaped, stackable closure caps (10) which have a convex outer face and a concave inner face and which are stacked in at least one closure cap stack in such a way that an upper closure cap (10) in the closure cap stack bears with its convex outer face on the concave inner face of a lower closure cap (10) lying immediately below in the closure cap stack, iv. a closure gripper (20) for gripping an uppermost closure cap (10) from the at least one closure cap stack, for transferring the gripped closure cap (10) to the sample vessel (PG) to be closed, and for introducing the gripped closure cap (10) into an opening of the sample vessel in order to tightly close the opening, wherein the closure gripper (20) has a centering piece which can be inserted into a closure cap (10) in such a way that it bears on the concave inner face of the closure cap (10). With such a system, automated closure of sample vessels is possible in a space-saving and efficient way. Furthermore, a method for automatic closure of sample vessels is also disclosed.