The present invention relates to a liquid handling and processing tool for analyzing a biological sample. Furthermore, the present invention relates to a fluid processing and detection module for processing a liquid sample and for detecting analyte in the sample.

The invention provides devices that improve tests for detecting specific cellular, viral, and molecular targets in clinical, industrial, or environmental samples. The invention permits efficient detection of individual microscopic targets at low magnification for highly sensitive testing. The invention does not require washing steps and thus allows sensitive and specific detection while simplifying manual operation and lowering costs and complexity in automated operation. In short, the invention provides devices that can deliver rapid, accurate, and quantitative, easy-to-use, and cost-effective tests.

A device for aggregating cells includes a cavity. The cavity includes a plurality of microwells for receiving at least one cell. Each of the microwells includes a vertical sidewall and a curved bottom. The microwells are made in a hydrogel layer. Each of said microwells has a diameter and an interwell distance between one microwell and another microwell, wherein a ratio for the interwell distance to the diameter is less than or equal to 1/10.

A bioluminescent single photon bioreactor for performing absolute quantification of light-producing activity by enzymes includes: a bioreactor that produces a bio-electronic signal; an electronic sensor that receives the bio-electronic signal and produces an electrical transduction signal; and an analyzer that receives the electrical transduction signal and absolutely quantifies light-producing activity by enzymes from the electrical transduction signal, such that the absolute quantification is accomplished quantum mechanically by determination of a second order autocorrelation function.

Methods and devices are provided for sample collection. In one example, a device is provided comprising at least one capillary tube or collection channel directed to a sample vessel, wherein in a one-step removal step of detaching the sample vessel from the collection channel, a vacuum force is created within the sample vessel, due in part of the pulling of the sealed vessel away from the device, wherein this vacuum force draw out residual sample that may still be resident in the collection channel.

Disclosed here are kits comprising pre-packed stabilizing solutions for stabilizing combinations of biomarkers demonstrating sufficient accuracy and specificity for identifying kidney injuries. Such kits can be better adapted for sample collection at a subject's dwelling, thus easing the burdensome requirement of continuous monitoring for kidney injury.

A microfluidic device comprises a first substrate and a second substrate, a gasket spacing the first substrate from the second substrate to define a fluid chamber between the first substrate and the second substrate, and at least one port for introducing a fluid sample into the fluid chamber. An inner edge face of the gasket defines a lateral boundary of the fluid chamber. A plurality of independently addressable array elements are provided on a surface of the first substrate facing the fluid chamber, and at least one circuit element is disposed on a surface of the second substrate facing the fluid chamber. The gasket is configured to provide a conductive path between a circuit element disposed on a surface of the second substrate facing the fluid chamber and an associated terminal.

Disclosed are a reagent holder, a testing apparatus assembly, an aqueous humor collection device and an aqueous humor collection method. The reagent holder (9) comprises a holder body and a functional station arranged on the holder body, wherein the functional station comprises a fluid holding tube insertion hole (91) and an elastic component. The elastic component can elastically act on a fluid holding tube (106) in the case where the fluid holding tube (106) is inserted into the liquid holding tube insertion hole (91) so as to enable the fluid holding tube (106) to elastically move in the direction of the central axis of the hole of the fluid holding tube insertion hole (91). By means of using the reagent holder to elastically fix the fluid holding tube (106), the rigid collision between a fluid drawing device and a bottom wall of the fluid holding tube (106) can be converted into an elastic collision, so as to prevent a testing apparatus from triggering a firing pin protection function during the fluid drawing process, such that the depth to which the fluid drawing device can extend into the tube cavity of the fluid holding tube (106) is greatly increased, and the sample extraction amount is thus effectively increased.

Assay system including assay apparatus and handheld single use assay devices for ElectroMagnetic Radiation (EMR) examination of a specimen. The assay devices include a housing, a specimen slide for elevation from an initial lowermost specimen introduction position to a final uppermost specimen examination position and a built-in liquid reagent dispensing arrangement for dispensing liquid reagent on the specimen slide. The assay apparatus automatically actuates an assay device and includes an imaging arrangement for obtaining specimen images.

The invention relates to a system with a seal between a manifold and a liquid container in which a sealing without an elastomer material is used, wherein the sealing properties of the seal are independent of the rotational position of the manifold in relation to the container