Lysis devices, methods, and systems are disclosed including a lysis device comprising a sample vessel having an outer surface, a microchannel within the confines of the outer surface, a first port extending through the outer surface to the microchannel, and a second port extending through the outer surface to the microchannel; and an acoustic transducer bonded to the outer surface of the sample vessel to form a monolithic structure, the acoustic transducer configured to emit ultrasonic acoustic waves into and/or to induce shear forces into a blood sample within the microchannel, thereby rupturing the blood cells.

A rapidly deployable cleanroom is constructed from multiple modular building sections that are side-by-side and have similarly sized lengths, as well as user-accessible panels in multiple of them for air, water, power, networking, and other utilities at a similar internal location along their lengths. The utility panels can be standardized such that each panel is substantially identical to one another. The modular building sections can be drawn together using tension cables within lateral hollow extruded structural tubes beneath and/or above the cleanroom, the tension system utilizing jackscrews to pull everything tight. Because the utility panels are at the same longitudinal location in the building sections, the joined structure and resulting open space “ballroom” style cleanroom has the utility panels aligned with each other inside the cleanroom.

A fluidic handling unit includes a baseplate, a fluidic inlet block, a fluidic outlet block, a pump in fluidic communication with the fluidic inlet block and the fluidic outlet block, a carrier control board in electrical communication with the pump, and a flow cell carrier comprising a microfluidic flow cell receiving area, wherein the flow cell carrier is configured to receive and retain the fluidic handling unit. A bottom surface of the fluidic handling unit is configured to complementary mate with a top surface of the flow cell carrier, or wherein a bottom surface of the flow cell carrier is configured to complementarily mate with a top surface of the fluidic handling unit.

A hand-held molecular diagnostic test device includes a housing, an amplification (or PCR) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (PCR) on the input sample. The detection module is configured to receive an output from the amplification module and a reagent formulated to produce a signal that indicates a presence of a target amplicon within the input sample. The amplification module and the detection module are integrated within the housing.

A modular laboratory-style computer-controlled system for multistep chemical processing for use in laboratory automation or chemical production is disclosed. The system comprised a plurality of interconnectable electrically-powered controllable chemical process modules having chemical input and output ports and at least one communications interface. Interconnection among the chemical process modules include both chemical flow interconnections for the transport of chemical materials and network interconnections for the transport of communications signals. In some implementations chemical flow interconnections are software controllable.

An apparatus for chemical separations includes a first substantially rigid microfluidic substrate defining a first fluidic port; a second substantially rigid microfluidic substrate defining a second fluidic port; and a coupler disposed between the first and second substrates, the coupler defining a fluidic path in fluidic alignment with the ports of the first and second substrates. The coupler includes a material that is deformable relative to a material of the first substrate and a material of the second substrate. The substrates are clamped together to compress the coupler between the substrates and form a fluid-tight seal.

A centrifugal rotor includes a support disk and a centrifugal carrier. The centrifugal carrier is assembled within the support disk. The centrifugal carrier includes an arc-shaped body, a sample application chamber, a sample metering chamber, a diluent chamber, a diluent metering chamber, a metering control member and a mixing chamber. The sample metering chamber is communicated with the sample application chamber. The sample metering chamber is positioned radially outward from the sample application chamber. The diluent metering chamber is communicated with the diluent chamber. The diluent metering chamber is positioned radially outward from diluent chamber. The metering control member is slidingly connected within or detachably fixed to the sample metering, chamber or the diluent metering chamber. The mixing chamber is communicated with the diluent metering chamber and the sample metering chamber respectively. The mixing chamber is positioned radially outward from both the diluent metering chamber and the sample metering chamber.

The invention relates to a test set (1) for a photometric measuring device, comprising a mixing container (2) which has a filling opening (3) and comprising a metering container (8) which can be sealingly inserted into the filling opening (3) of the mixing container (2) and which contains a liquid reagent (13) in a closed cavity (9). The cavity (9) has a closure plunger (11), which can be moved axially in the cavity (9), at a first end of the metering container (8), said closure plunger generating a specifiable filling pressure in the reagent (13), and the metering container (8) has a closure membrane (10) at a second metering container and which can be inserted into the mixing container (2). According to the invention, the closure membrane (10) is equipped with a predetermined breaking point (20) which breaks open when the filling pressure is exceeded in a defined manner as a result of an axial movement of the closure plunger (11), said predetermined breaking point (20) of the closure membrane (10) being formed as a linearly extending material taper of the closure membrane (10), wherein the taper is arranged eccentrically in the region of an opening (24) in the base (23) of the substantially cylindrical metering container (8).

A system for rapid analysis of a fluid sample for detection of at least one viable microbial organism therein. The system comprises a cartridge that is demountably engageable with a reader component. The cartridge has a first well receiving a fluid sample, with a second well and third well imbedded under portions of the first well. The second well has a sensor configured to send a reference signal to the reader component, while the third well has a sensor configured to send a sample signal to the reader component. When in use, the cartridge is engaged with the reader component and a fluid sample is placed into the first well. The reader component controllably illuminates the third well and comprises a detector that detects differences in photocurrent and/or spectra between the reference signal and the sample signal from the illuminated third well.

A modular device for treatment and/or analysis of substances comprises a supply device which supplies at least one functional fluid to at least one process device, wherein the supply device has multiple receiving means for receiving in each case one process device. The receiving means each have multiple supply ports, including an inflow supply port and an outflow supply port for transmission of a functional fluid. The process device has a functional region for the treatment and/or analysis of substances, a fluid line which encloses the functional region, and multiple coupling means for coupling to the supply ports of a receiving means. For each receiving means, a first valve device is provided in the region of the inflow supply port and a second valve device is provided in the region of the outflow supply port.