A discharge device includes a discharge head that discharges a liquid material from a nozzle opening connected to the cavity by varying the internal pressure of a cavity using an actuator. The discharge head includes a monitoring portion provided between the cavity and the nozzle opening and the discharge device further includes a detection apparatus that detects the number and/or form of the particle-like bodies included in the liquid material in the monitoring portion of the discharge head and a control unit that drives the actuator according to the detection result of the detection unit to change the state of the particle-like bodies included in the liquid material of the monitoring portion.

A device for detecting the deposition of a biological liquid sample for subsequent analysis, the device including a substrate for receiving the biological liquid sample, and two electrodes, each electrode having a free end, the respective free ends configured to be near or in contact with a surface of the substrate, the distance between the electrodes being such that the sample or at least a part of the sample is located between them.

A droplet dispensing device includes a head part discharging droplets, and a sensor plate disposed between the head part and a well plate, the sensor plate having a plurality of opening parts formed respectively corresponding to a plurality of wells and a plurality of electrostatic capacitance sensors each disposed at a circumferential edge of the plurality of opening parts.

A droplet dispensing device includes an adjustment plate; a first sensor, provided on an upper surface of the adjustment plate and detecting a position of the transparent droplet; a tray, on which one of the well plate and the adjustment plate is detachably mounted; a head part, discharging the transparent droplet; and a CPU, switching an operation mode from one of a first mode and a second mode to the other. In the first mode, the transparent droplet is discharged from the head part toward the well plate, and in the second mode, the transparent droplet is discharged from the head part toward the first sensor. The CPU adjusts the position on the well plate in which the transparent droplet is discharged from the head part in the first mode based on a position of the transparent droplet detected by the first sensor in the second mode.

An apparatus and a method for providing one or more substance liquids to a microfluidic channel network (30). The microfluidic apparatus includes valves for switching the one or more substance liquids to a microfluidic channel network (30). The apparatus can be used to generate a sequence of the one or more substance liquids as individual droplets in an immiscible separation liquid wherein individual ones of the sequence of droplets are located between the separation liquid.

Means and methods for dispensing small amounts of liquid from multi-channel microdispensing devices, suitable for use in automatic processing in biological assays and for the cultivation of cells and tissues, by means of optical control of the dosed liquid by specific light barrier units.

A system includes a device configured to facilitate an interaction between a first fluid flow and a second fluid flow within a flow path of the device; an optical sensor configured to obtain one or more images representing the flow path; an image analysis module configured to: process the images to identify at least one droplet generated in a flow path of the device by the interaction between the first fluid flow and the second fluid flow, and estimate a size of the at least one droplet; and a control system configured to: determine that the size of the at least one droplet satisfies a threshold condition, and responsive to determining that the size of the at least one droplet satisfies the threshold condition, generate a signal that causes an adjustment to a flow rate of at least one of the first fluid flow or the second fluid flow.

The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control.

A microfluidic apparatus includes a microfluidic chip for MicroOrganoSpheres (MOS) generation. A first channel is defined in a surface of the microfluidic chip and includes: a droplet generation portion including an inlet portion, a junction between the inlet portion and an emulsifying fluid channel, and a chamber downstream of the junction. A cross-sectional area of the chamber is larger than that of the inlet portion. The first channel includes a polymerization portion downstream of the droplet generation portion, the polymerization portion having a serpentine configuration. The apparatus includes a cartridge for MOS demulsification, including: a collection container; a substrate disposed on the collection container, and a membrane disposed between the collection container and the surface of the substrate. A second channel is defined in the surface of the substrate that faces the collection container and is fluidically connected to an output of the polymerization portion of the first channel.

An assay-protocol-specific multi-channel fluid-dispenser cassette for an automated assay fluid dispensing system may include a structure with multiple fluid channels within the structure to contain and control respective assay fluids. Each fluid channels may have an outlet. A driver interface may be carried by the structure removably and mechanically engageable with a dispenser driver of a dispenser so that the dispenser driver can control the dispensing of fluids from the structure directly onto underlying reaction sites while each of the fluid channels remain as part of the structure. An assay-protocol-indicative cassette-type identifier may be formed in or attached to the structure and indicative of different assay protocols for all of the multiple fluid channels. The assay-protocol-cassette-type identifier may be readable by the cassette driver in response to the multi-channel fluid-dispenser cassette being removably connected to the dispenser.