A cell processing system, fluidics cartridge, and methods for using actuated surface-attached posts for processing cells are disclosed. Particularly, the cell processing system includes a fluidics cartridge and a control instrument. The fluidics cartridge includes a cell processing chamber that has a micropost array therein, a sample reservoir and a wash reservoir that supply the cell processing chamber, and a waste reservoir and an eluent reservoir at the output of the cell processing chamber. A micropost actuation mechanism and a cell counting mechanism are provided in close proximity to the cell processing chamber. A method is provided of using the cell processing system to collect, wash, and recover cells. Another method is provided of using the cell processing system to collect, wash, count, and recover cells at a predetermined cell density.

A sample preparation module accepts a sample including a target analyte. The sample preparation module processes the sample through several reaction chambers and a solid phase column. Different reagents are present in the reaction chambers. The eluted analyte is then transferred to the amplification module, where it is further processed and amplified for optical analysis.

Apparatus and associated methods relate to an adaptable microenvironment for cellular and biological processing in a traceable, transportable unit. In an illustrative example, an apparatus consists of one or more portable cell tissue containment modules that may be removably interconnected to perform a processing step and/or transfer the stored medium to another module. Associated apparatus and methods are proposed to ensure non-contaminating mechanical or fluid communication between a plurality of modules or between a module and peripheral equipment, to limit process errors such as steps performed out of order, and to intrinsically manage identification of tissue samples with accompanying process data in a manner that decreases risk of mislabeling or otherwise mishandling a sample at all stages of the production and treatment process.

A lab-on-a-chip cartridge includes a housing defining four separate chambers. A fluid (such as whole blood) flows through one of the chambers and into another one of the chambers, which includes a filter membrane. The filter membrane is rotated to separate a first fluid component (such as plasma) from a second fluid component (such as red blood cells), with the first fluid component passing through the filter membrane and the second fluid component not passing through the filter membrane. The separated first and second fluid components each flow into a different one of the remaining chambers, with the first fluid component contacting a lab-on-a-chip device for analyzing the first fluid component.

A disease screening device (100) comprising a substrate (101) and a sonication chamber (102) formed on the substrate (101). The sonication chamber (102) is provided with an ultrasonic transducer (105) which generates ultrasonic waves to lyse cells in a sample fluid within the sonication chamber (102). The device (100) comprises a reagent chamber (111) formed on the substrate (101) for receiving a liquid PCR reagent. The device (100) comprises a controller (23) which controls the ultrasonic transducer (105) and a heating arrangement (128) which is provided on the substrate (101). The device (100) further comprises a detection apparatus which detects the presence of an infectious disease, such as COVID-19 disease.

A device for filtration or extraction using at least one filtration membrane is disclosed. The device is shaped like a Buchner funnel, but small enough to fit with wide bore pipette tips, slip tip syringes or an adaptor of a robotic liquid handler or pipettor. It also houses one or more filtration membranes and or a separation resin. A reservoir adaptor can be added to the top in a fluid tight manner to provide a removable large volume container where needed for larger samples, and a gasket adaptor allows the reservoir to be connected to other devices in a fluid tight manner.

A safety cabinet that includes an opening portion in a front surface of a work space and a front shutter, and supplies purified air into the work space from above. The front shutter slides in an upward and downward direction to close a part or an entirety of the opening portion. The front shutter includes a small window shutter that slides in a lateral direction.

There is provided a device and method for separation of blood, including sedimentation of plasma using PVA. The device comprises an inner container enclosed in an outer container, wherein upon alignment of respective openings, allows sample to exit from the inner container into a reaction structure. The reaction structure comprises one or more layers, each with one or more portions each containing concentrations of one or more chemicals.

There is provided a device and method for separation of blood, including sedimentation of plasma using PVA. The device comprises an inner container enclosed in an outer container, wherein upon alignment of respective openings, allows sample to exit from the inner container into a reaction structure. The reaction structure comprises one or more layers, each with one or more portions each containing concentrations of one or more chemicals.

A microfluidic device includes a semiconductor microchip including fluid active circuitry and transistor circuitry, wherein the transistor circuitry provides onboard logic at the semiconductor microchip to control the fluid active circuitry. The microfluidic device further includes a microfluidic chamber fluidly coupled to an inlet port and an outlet port, wherein the microfluidic chamber is defined in part by a microchip surface with the active circuitry positioned to interact with fluid introduced into the microfluidic chamber and partially defined by an enclosing surface. The microchip surface, the enclosing surface, or both include a chemically-modified microfluidic chamber surface that is selectively interactive with a target component of the fluid.