Devices, kits, and their methods of use for lysing and/or purifying biological particles, e.g., nuclei are provided. One or more thixotropic layers can be employed in a vessel to purify biological particles. A device with sharp features may be employed to lyse biological particles or the contents thereof.

Provided is a blood collection container with which a specimen with a high leukocyte recovery rate and a small amount of contaminating erythrocytes can be obtained. A blood collection container according to the present invention is a blood collection container by which a predetermined amount of blood is collected, the blood collection container including: a blood collection container main body; and a hemocyte separation material contained in the blood collection container main body, the hemocyte separation material having a specific gravity at 25° C. of 1.075 or more and 1.093 or less, and the blood collection container including: a configuration of including a hemagglutinating agent contained in the blood collection container main body (configuration A2); or a configuration of including an osmotic pressure regulator contained in the blood collection container main body, and when a water-soluble component contained in the blood collection container main body is dissolved with physiological saline in an amount equal to a predetermined amount of blood to be collected in the blood collection container to obtain a solution for osmotic pressure measurement, the solution for osmotic pressure measurement having an osmotic pressure of 300 mOsm/L or more and 500 mOsm/L or less (configuration B2).

The present invention relates to a blood components collection and separation media (1) comprising a substrate (3) having a maximal flow pore size enabling the retention of at least red cells on the surface of the substrate (3), the blood components collection and separation media (1) comprises boundary walls (7) forming a pattern (9) and being made of a hydrophobic resin, and the pattern (9) presenting: a collection zone (91); at least one storage zone (93) aimed at collecting at least one component of the whole blood sample (5); and at least one channel (95) connecting the collection zone (91) to the at least one storage zone (93), the channel (95) forming a bottleneck between the collection zone (91) and the storage zone (93). The present invention further relates to a blood components collection and separation device and a blood components separation and extraction process.

A single junction sorter for a microfluidic particle sorter, the single-junction sorter comprising: an input channel, configured to receive a fluid containing particles; an output sort channel and an output waste channel, each connected to the input channel for receiving the fluid therefrom; a bubble generator, operable to selectively displace the fluid around a particle to be sorted and thereby to create a transient flow of the fluid in the input channel; and a vortex element, configured to cause a vortex in the transient flow in order to direct the particle to be sorted into the output sort channel.

The present invention relates to the field of micro fluidics. Specifically, the present invention relates to a novel flow cell for the selective enrichment of target particles or cells from a fluid. The flow cell exhibits a novel design which greatly improves the target particle or cell yield. The invention also provides a micro fluidic device, comprising the flow cell according to the invention. In another aspect, the invention relates to the use of a flow cell or a micro fluidic device of the invention for the isolation of target particles or cells from a fluid sample. Finally, the invention relates to a method for the selective enrichment of target particles or cells from a fluid using the flow cell of the invention.

An automated biologic sample extracting system from a set of biological samples with a small footprint with minimal movement of the set of consumables, thereby reducing potential contamination during the extraction process. The extracting system comprising a set of reaction tubes, a storage unit to store a set of consumables; a sample preparation unit; a sample extraction unit; a waste unit; a plurality of robots to move tubes, samples, and boxes, and a programmable control system programmed to process samples in a serial pattern in which a series of samples follow one another to be processed in a time sequence and in succession so that it keeps a fixed processing turnaround time of each sample no matter when a sample would start the process.

A sample collection device having a sample container, a solid phase binding material, and a container sealing component is presented. The sample container may have a housing that forms an opening for receiving a sample, and that encloses a space for holding the sample. The solid phase binding material may be disposed within the space enclosed by the housing of the sample container and may be adapted, when the sample contains an analyte, to bind specifically to the analyte. The container sealing component may be removably attachable to the sample container at the opening thereof, and may be adapted, when attached to the sample container, to form a seal around the opening of the sample container.

Devices and methods for performing pre-analysis sample processing of biological and chemical samples using robotic liquid handlers are disclosed. Methods for solid phase extraction, protein precipitation and filtration of biological and chemical samples using automation and the devices in a rapid and convenient way are described.

Systems and methods for cleansing blood are disclosed herein. The methods include acoustically separating target particles from elements of whole blood. The whole blood and capture particles are flowed through a microfluidic separation channel formed in a thermoplastic. At least one bulk acoustic transducer is attached to the microfluidic separation channel. A standing acoustic wave, imparted on the channel and its contents by the bulk acoustic transducer, drives the formed elements of the blood and target particles to specific aggregation axes.

The present invention provides a method for the synthesis of an injectable composition comprising a [.sup.18F]-labelled pyridaben derivative that is advantageous over prior methods. In particular, the method of the present invention comprises a method of radiosynthesis that permits a more facile purification using solid phase extraction (SPE).