A mobile phase supply device, for supplying a mobile phase for a sample separation apparatus for separating a fluidic sample, includes a fluidically normally closed cap device configured to be mounted on a mobile phase container containing a mobile phase, and a fluidically normally closed port device configured for being mechanically connected with the cap device in such a way that, upon establishing a mechanical connection between the port device and the cap device, both the port device and the cap device are converted into a fluidically opened configuration.

An assembly for forming a microchamber for an inverted substrate is disclosed. The assembly can include a body having a chamber formed therein. A dispensing cavity can be provided to supply a reagent to the chamber. A slide support structure can be configured to support the slide such that the tissue sample faces the chamber when the slide is mounted to the slide support structure. The chamber and the slide support structure can be dimensioned such that, when the reagent is supplied to the dispensing cavity, the reagent is drawn to the chamber by way of capillary forces acting on the reagent.

There is provided an arrangement (100) which allows for mixing a first fluid with a second fluid at a predetermined volume mixing ratio in a capillary driven fluidic system. The arrangement (100) allows filling an initially empty mixing chamber (110) with the first fluid. The arrangement then allows emptying a predetermined fraction of the first fluid from the mixing chamber (110) such as to form an empty space in the mixing chamber (110). The arrangement then allows filling the empty space of the mixing chamber (110) with the second fluid, thereby allowing a predetermined volume of the first fluid to mix with a predetermined volume of the second fluid over time.

A fluid device includes a substrate and a gas-liquid separating filter, the substrate has a flow path through which a solution flows, a reservoir, in which the solution is accommodated, connected to the flow path, an injection hole configured to connect the reservoir to the outside, and an air introduction hole branched off from the injection hole and connected to the outside, and the gas-liquid separating filter is disposed in a path of the air introduction hole, allows passage of a gas flowing through the air introduction hole, and prevents passage of a liquid flowing through the air introduction hole.

A system and method for receiving and delivering a fluid, the system comprising: a body configured to interface with an opening of a reservoir and defining: a protrusion defining a set position of the body relative to the reservoir; a wall extending from the protrusion; a receiving surface coupled to the wall and sloping from an apex to a nadir along a first direction, the receiving surface comprising a vent; and an outlet positioned closer to the nadir than the apex of the receiving surface and displaced from the vent, the outlet comprising an extension from the body, the extension configured to contact an interior wall of the reservoir, wherein the body comprises: a bubble-mitigating operation mode in which the receiving surface receives and transmits the fluid along the receiving surface, and a fluid-transmitting operation mode in which the body directs the fluid along the interior wall of the reservoir.

A biological sample collection system includes: a sample collection vessel having a sample collection chamber for receiving a biological sample; a sealing cap including a reagent chamber for storing a sample preservation reagent and being configured to associate with the sample collection vessel; and a selectively movable valve at least partially disposed within the sealing cap. The selectively movable valve includes a post with an interior chamber and fluid vent and a valve head associated with a distal portion of the post that initially occludes the fluid vent when the valve is in the closed configuration. Associating the sealing cap with the sample collection vessel causes a physical rearrangement of the post and the valve head in order for the fluid vent to become unoccluded by the valve head, thereby placing the valve in an open configuration and allowing fluid communication between the reagent chamber and the sample collection vessel.

The present invention relates to a liquid handling and processing tool for analyzing a biological sample. Furthermore, the present invention relates to a fluid processing and detection module for processing a liquid sample and for detecting analyte in the sample.

A system and method for receiving and delivering a fluid, the system comprising: a body configured to interface with an opening of a reservoir and defining: a protrusion defining a set position of the body relative to the reservoir; a wall extending from the protrusion; a receiving surface coupled to the wall and sloping from an apex to a nadir along a first direction, the receiving surface comprising a vent; and an outlet positioned closer to the nadir than the apex of the receiving surface and displaced from the vent, the outlet comprising an extension from the body, the extension configured to contact an interior wall of the reservoir, wherein the body comprises: a bubble-mitigating operation mode in which the receiving surface receives and transmits the fluid along the receiving surface, and a fluid-transmitting operation mode in which the body directs the fluid along the interior wall of the reservoir.

A system includes a cartridge and an instrument. The cartridge includes a cartridge body defining an input port aligned with a central axis of the cartridge body, a plurality of channels in fluidic communication with the input port and extending radially to a plurality of reaction chamber connectors, a plurality of reaction chambers disposed at a radial distance from the central axis of the cartridge body and distributed at angles relative to the others of the plurality of reaction chambers. The system further includes an instrument including an incubation block configured to receive the plurality of reaction chambers; a motor and socket to connect with the cartridge; an illumination source having an illumination pathway; and a camera disposed in a signal pathway intersecting the illumination pathway.

A bio-information detection substrate and a gene chip are provided. The substrate includes a first main surface, the first main surface includes a test region and a dummy region located around the test region, at least one accommodation region is disposed on the first main surface, and the accommodation region is located in the dummy region.