There is provided a sample processing cartridge comprising a. a sample entry location; b. a closed sample processing chamber; c. a sample analysis location comprising a sample analysis well; d. a first channel fluidly connecting the sample entry location and the sample processing chamber; e. a second channel connecting the sample analysis location and the sample processing chamber, the second channel comprising a closed or closable second channel valve; wherein the sample processing chamber comprises a second channel port providing fluid connection between the second channel and the sample processing chamber, the second channel port being positioned in a sample accumulating region of the sample processing chamber. There is also provided a sample processing system comprising the cartridge, and methods of use of the cartridge and processing system in a sample processing assay.

The invention relates to an integrated tubular reaction device, which comprises a reaction vessel, a reaction vessel including at least two tubular chambers, a channel connecting at least two tubular chambers and an opening; a cover body, which can be worked with the opening, and a cover body including a through hole; a seal, which includes a sealing plug which can be worked with the through hole. The integrated tubular reaction device solves the problem of contamination of reaction products in the process of multiple or multi-step biological enzyme reaction, and can realize multiple or multi-step biological enzyme reactions in the same device.

A circuit with electrical interconnect for external electronic connection and sensor(s) on a die are combined with a laminated manifold to deliver a liquid reagent over an active surface of the sensor(s). The laminated manifold includes fluidic channel(s), an interface between the die and the fluidic channel(s) being sealed. Also disclosed is a method, the method including assembling a laminated manifold including fluidic channel(s), attaching sensor(s) on a die to a circuit, the circuit including an electrical interconnect, and attaching a planarization layer to the circuit, the planarization layer including a cut out for the die. The method further includes placing sealing adhesive at sides of the die, attaching the laminated manifold to the circuit, and sealing an interface between the die and fluidic channel(s).

The invention relates to a door assembly (1) allowing a sealed transfer between two enclosed volumes, comprising a flange (2) arranged to delimit an opening in one of the enclosed volumes, and a door (4) that extends along an axis (C) and is hingedly fastened to/mounted on the flange (2) so as to move from a closed position in which the door (4) closes the passage opening (3), into an open position, characterized in that the door (4) is fastened to the flange (2) by a double-joint linkage mechanism (5) comprising a first joint (6) arranged to allow a rotational movement about an axis (A) perpendicularly to the axis (C) of the door by a maximum of 30 degrees in relation to the plane of the passage opening (3), and a second joint (7) arranged to allow a rotational movement about an axis (B) parallel to the axis (C) of the door.

The present disclosure provides systems and methods for sample analysis. The system comprises a container. The container comprises a sample receptacle and a cap, and the cap comprises a reservoir for retaining a composition, a first piercing member and a first pierceable barrier for sealing said composition within said reservoir. There is also provided a method for sample analysis.

The present invention describes an integrated apparatus that enables identification of migratory cells directly from a specimen. The apparatus only requires a small number of cells to perform an assay and includes novel topographic features which can reliably differentiate between migratory and non-migratory cell populations in a sample. Both the spontaneous and chemotactic migration of cancer cells may be measured to distinguish between subpopulations within a tumor sample. The migratory cells identified using the apparatus and methods of the present invention may be separated and further analyzed to distinguish factors promoting metastasis within the population. Cells in the apparatus can be treated with chemotherapeutic or other agents to determine drug strategies to most strongly inhibit migration. The use of optically transparent materials in some embodiments allows a wide range of imaging techniques to be used for in situ imaging of migratory and non-migratory cells in the apparatus. The apparatus and methods of the present invention are useful for predicting the metastatic propensity of tumor cells and selecting optimal drugs for personalized therapies.

Modular active surface devices for microfluidic systems and methods of making the same including adhesive-free assembly are disclosed. In some embodiments, the presently disclosed modular active surface devices and methods provide adhesive-free assembly processes, such as, but not limited to, laser beam welding (LBW) processes, ultrasonic welding processes, heat welding processes, chemical bonding processes, mechanical compression processes, and the like. In some embodiments, the modular active surface devices and methods provide a reagent hopper or well that is out-of-plane with the reaction chamber.

A test container includes an inlet, a first storage portion, a second storage portion, a first flow channel that connects the first storage portion to the second storage portion, a first cylinder of which one end is connected to the first storage portion via a second flow channel and the other end is open to an outside, a second cylinder of which one end is connected to the second storage portion via a third flow channel and the other end is open to an outside, a first plug provided in the first cylinder, and a second plug provided in the second cylinder. An internal space including the first storage portion, the second storage portion, the first flow channel, the second flow channel, and the third flow channel is capable of being pressurized in a case where the first plug and the second plug are pressed and moved from the outside.

An adapter for connecting an array of pipette tips having through bores with conical upper ends to a multichannel air displacement pipettor having a plurality of ports with compliant internal sealing surfaces. The adapter comprises a planar base with an array of openings extending between its top and bottom surfaces. Sealing tubes project upwardly from the top surface, and tip mounting tubes project downwardly from the bottom surface, with pairs of sealing tubes and tip mounting tubes being arranged coaxially and in communication with respective ones of the openings in the base. The tip mounting tubes are externally dimensioned and configured for insertion into the conical upper ends of the pipette tips, and the sealing tubes are externally configured and dimensioned for insertion into the ports of the pipettor and into sealing interengagement with their compliant internal sealing surfaces.

The invention concerns an analyte meter (10) for medical tests having a meter housing (12), a strip port (14) mounted in an opening of the meter housing (12) and configured to receive a measuring part of a test strip (18), and a sealing insert (16) which is arranged within the strip port (14) and provides an insertion path for the test strip (18). For improved screening against contamination, it is proposed that the sealing insert (16) comprises a plurality of sealing elements (42) which are arranged consecutively along the insertion path, wherein each of the sealing elements (42) has a slit (46) that forms a sealed aperture for the test strip (18) to pass through.