The present technology provides for an apparatus for detecting polynucleotides in samples, particularly from biological samples. The technology more particularly relates to microfluidic systems that carry out PCR on nucleotides of interest within microfluidic channels, and detect those nucleotides. The apparatus includes a microfluidic cartridge that is configured to accept a plurality of samples, and which can carry out PCR on each sample individually, or a group of, or all of the plurality of samples simultaneously.

The technology described herein generally relates to systems for extracting polynucleotides from multiple samples, particularly from biological samples, and additionally to systems that subsequently amplify and detect the extracted polynucleotides. The technology more particularly relates to microfluidic systems that carry out PCR on multiple samples of nucleotides of interest within microfluidic channels, and detect those nucleotides.

A pipette with an adjustable volume comprises a housing comprising an outside surface, at least one seat defining an opening, and a displacement apparatus defining a displacement chamber comprising a displacement element configured to be displaced therein. A stroke rod is coupled to the displacement element and configured to be displaced relative to the housing order to displace the displacement element. An adjusting apparatus is configured to adjust a position of an upper stop in the housing, a display apparatus is configured to display a set dosing volume, and a coupling apparatus is positioned between the adjusting apparatus and the display apparatus. The coupling apparatus is configured to couple the adjusting apparatus to the display apparatus in an engaged state and configured to uncouple the adjusting apparatus from the display apparatus i.n a disengaged state.

A pipette (1) having a cylinder (10), a piston (8), a volume display (25) for displaying a pipetting volume (14) associated with the piston stroke, a display adjustment mechanism (22) for changing the volume display (25), an adjustment display for indicating an adjustment of the pipette (1) via the volume display (25), and a volume adjustment mechanism (19) for changing the piston stroke, the volume adjustment mechanism (19) being coupled to the display adjustment mechanism (22) in a first mode of operation of the pipette (1), and the volume adjustment mechanism (19) being decoupled from the display adjustment mechanism (22), and the display adjustment mechanism (22) being coupled to the adjustment display in a second mode of operation of the pipette (1), a method of operating such a pipette.

A device includes: a first portion configured to be grasped by the hand of the user, and a second portion defining a reservoir containing a control material, wherein the control material contains a target analyte in a known or predetermined concentration. A method of verifying the accuracy of an analyte monitoring device includes receiving a fluid sample, identifying the fluid sample as a control solution, and analyzing the fluid sample.

One aspect of the present invention is to provide systems and methods that improve the accuracy of an assay that comprise at least one or more parameters each having a random error.

A verification of a pipette results in a release or a warning message. A liquid measuring container (110) receives the pipette liquid volume (V.sub.P) to be verified. A loading cell (120) is connected to the liquid measuring container in a force-transmitting manner. The loading cell outputs a measurement signal (ms) corresponding to the weight force (F.sub.G) acting thereon. A processing unit (130) detects and processes the measurement signal (ms), determines a first weight force (G.sub.t1) at time point (t.sub.1) and determines a second weight force (G.sub.t2) at time point (t.sub.2). The pipette liquid volume is calculated and the calculated value is assigned to a pipette volume class (K.sub.i) having a defined class nominal value (VK.sub.i). The processing unit tests whether or not an absolute value of the volume difference (ΔV) is within a predetermined tolerance value (T) for the assigned pipette volume class. The processing unit outputs the test result.

A thermo-gravimetric analysis system includes a chamber having an interior; and a sample crucible connected to and inside of the chamber, the sample crucible configured to hold a sample material. The system further includes a reference crucible connected to and inside of the chamber; and a metal organic framework (MOF) crucible connected to and inside of the chamber, separate from the sample crucible, the MOF crucible including an MOF material.

Compositions and methods are provided for making hyper compliant polymer particles by inverse emulsification and having a predetermined mechanical compliance and a predetermined size with a monodisperse diameter. Compositions and methods are provided for use of hyper compliant polymer particles in drug delivery, assay, particle image velocimetry, ceramics, cosmetics, deconvolution, electronic paper, insulation, personal care, standards, retroreflective paint and paint applications, thickening agents, regenerative medicine, device calibration, micro-carriers and force indicators.

An automated analysis instrument operates to detect inadequate dispensation of a fluidic substance on a tray. The instrument includes an image capturing device to capture an image of at least a portion of the tray including a receptacle portion and a surrounding portion around the receptacle portion. The instrument then identifies the surrounding portion of the at least the portion of the tray in the image, evaluates color components of the image corresponding to the surrounding portion of the at least the portion of the tray, and determines whether the fluidic substance is present on the surrounding portion of the at least the portion of the tray based on at least one of the color components.