An embodiment includes a sample receiving region, a first diagnostic element that includes one or more colorimetric analysis regions, and a second diagnostic element that includes one or more lateral flow assay analysis regions. The embodiment also includes a first flow path that allows a portion of a liquid deposited at the sample receiving region to flow to the first diagnostic element. The embodiment also includes a second flow path that allows a portion of the liquid deposited at the sample receiving region to flow to the second diagnostic element.

A single junction sorter for a microfluidic particle sorter, the single-junction sorter comprising: an input channel, configured to receive a fluid containing particles; an output sort channel and an output waste channel, each connected to the input channel for receiving the fluid therefrom; a bubble generator, operable to selectively displace the fluid around a particle to be sorted and thereby to create a transient flow of the fluid in the input channel; and a vortex element, configured to cause a vortex in the transient flow in order to direct the particle to be sorted into the output sort channel.

A semiconductor sensor-based near-patient diagnostic system and related methods.

The present disclosure relates to a rapid genetic screening method and device. The method includes: collecting a sample to be tested of a patient through a micro-fluidic chip, where the sample to be tested includes a whole blood or saliva or nasopharyngeal swab or wound swab sample of a patient; lysing and amplifying the sample to be tested in the micro-fluidic chip to obtain an amplified nucleic acid segment; fusing a biosensor with amplification liquid, where the biosensor is provided with a DNA probe which can only be bounded to a specific nucleic acid segment and in which an impedance may dramatically change before and after the bounding; and inputting an electrical signal to the biosensor, testing a signal of an output end, and determining whether a nucleic acid segment matched with the DNA probe exists in the sample to be tested of the patient. The DNA probe can be replaced to test whether different nucleic acid segments exist. A person only need to collect the sample to be tested of the patient, select a probe, and configure simple parameters, so that the operations are simple, without performing nucleic acid extraction and purification on the sample to be tested, and the testing efficiency is greatly improved.

A portable detector is disclosed for detecting certain analytes of interest, such as genetic material (e.g., nucleic acids). The detector includes a reading component for the detection of the analytes, and control circuitry for controlling operation of the reading component. Processing circuitry may be included to perform both primary analysis of acquired data, and where desired, secondary analysis. Where desired, some or all of the computationally intensive tasks may be off-loaded to enhance the portability and speed of the device. The device may incorporate various types of interface, technologies for reading and analysis, positioning system interfaces, and so forth. A number of exemplary use cases and methods are also disclosed.

The present disclosure features portable wide field fluorimeter systems, e.g., in the form of low-cost mobile platforms, and methods to perform fluorometric assays to detect a change in fluorescence intensity in liquid samples, e.g., caused by the presence of a target analyte, e.g., a protein, e.g., an enzyme (e.g., β-lactamase) expressed by a target pathogen in a liquid sample in a point-of-care setting. In some implementations, a portable system for detecting a change in fluorescence intensity in a liquid sample includes a microfluidic device, an optical assembly including an emission filter and one or more lenses, and an analyzer device that collects and processes a fluorescent signal for the detection of a target analyte produced by the target pathogen present in the liquid sample.

A work glove is installed at the port flange, with the result that the operator can enter the working chamber of the containment in a protected manner. A multiplicity of port flanges are usually mounted on the containment and a work glove is fastened in each case to the respective port flange. Machinery for processing material to be treated is often set up in the working chamber. In order to temporarily block the access, a shut-off part which can be moved into a blocking position and an open position is provided. In order to record personal data relating to the operator, the arrangement has a capture unit which has a connection to a microcontroller.

An analyte detection device with intelligent identification function, includes: a transmitter; a sensor unit including a sensor base and a sensor with first parameter, and one end of the sensor inserted under the skin while the other end is installed in/on the sensor base; a bottom base; at least one physical unit with second parameter which corresponds to the first parameter arranged on the bottom base, on the sensor base or on/in the transmitter; and a detection circuit for detecting the second parameter which can be transmitted to the transmitter. Using this detection device, the transmitter can automatically identify the corresponding sensor information.

A system and method for diagnosing infectious disease using integrated surface acoustic wave sensor technology includes an efficient, low-cost integrated surface acoustic wave (SAW) biosensor based system for point-of-care diagnostics. The SAW biosensor, sample receiving portions and interface portions of the system are configured on a disposable cartridge.

A MEMS-based particle manipulation system which uses a particle manipulation stage and a plurality of laser interrogation regions. The laser interrogation regions may be used to assess the effectiveness or accuracy of the particle manipulation stage. In one exemplary embodiment, the particle manipulation stage is a microfabricated, flap-type fluid valve, which sorts a target particle from non-target particles in a fluid stream. The laser interrogation stages are disposed in the microfabricated fluid channels at the input and output of the flap-type sorting valve. The laser interrogation regions may be used to assess the effectiveness or accuracy of the sorting, and to control or adjust sort parameters during the sorting process. One or more feedback loops may be used to improve the particle manipulation process, based on data acquired during the first interrogation and/or during a downstream confirmation. Artificial intelligence techniques may be used to good effect.