Disclosed are cartridge components, cartridges, systems, and methods for isolating analytes from biological samples. In various aspects, the cartridge components, cartridges, systems, and methods may allow for a rapid procedure that requires a minimal amount of material from complex fluids.

Embodiments can provide a test tube vacuum retainer system, comprising an outer body comprising a midline plate; one or more side walls, a bottom wall, and a top plate comprising an access hole; a test tube holder comprising a sealant ring; a base; and a vacuum tube comprising an external outlet; wherein the test tube holder is secured within the outer body to the base, which in turn is secured to the midline plate; wherein the vacuum tube is connected to the test tube holder at a first end, and the external outlet is configured to be connected to a vacuum pump configured to apply a vacuum force to the test tube holder when a test tube is inserted into the access hole and placed onto the test tube holder.

A system for diagnostic testing may include a meter for performing a diagnostic test on a sample applied to a test media, the meter having a housing and an interface for receiving a signal representing coding information, and a container configured to contain test media compatible with the meter, the container having a coding element associated therewith. Additionally, the system may provide a mechanism for removing the meter from an interconnected test container and reattaching it to a new container using on-container coding methods that can recalibrate the meter for the new container of test strips.

An analysis cartridge includes a first cover, a second cover, a plurality of containers, a plurality of fluid tunnels and a rotary valve. The second cover has two opposite surfaces, a plurality of first through holes and a second through hole individually penetrate through the two opposite surfaces, and the first cover is attached to the second cover. The plurality of containers are disposed between the first cover and the second cover, with each of the containers being aligned to and filled in the first through holes. The plurality of the fluid tunnels are disposed on the first cover, and each of which is individually connected with a first pipette. The rotary valve is rotatably disposed between the first cover and the second cover to correspond to the second through hole, and a flow channel disposed on the rotary valve is connected with the containers individually.

The system includes a pipette tip with a proximal end that has a rim. The rim defines a proximal opening adapted to receive a pipetter, and the rim includes a rim conical edge. The system also has a support card with a top surface, a pipette tip receiver opening within the top surface, the opening adapted to receive the pipette tip and having a receiver opening conical edge. The rim conical edge and the receiver opening conical edge are constructed such that when the pipette tip is disposed of in the pipette tip receiver opening, the rim conical edge abuts the receiver opening conical edge, and the top surface is flush with or nearly flush with the rim.

A heat sealing product suitable for seating one or more individual containers, said heat sealing product comprising: (i) a plurality of individual heat seals set out in a configuration substantially corresponding to the shape and configuration of the container(s) to be sealed, the size and shape of the individual heat seals corresponding substantially to the size and shape of the tops of the individual container(s) to be sealed; (ii) a peelable support film layer coated on one side with a low tack adhesive, the low tack adhesive serving to hold the individual heat seals in place on the support film layer in the desired configuration prior to the sealing process; (iii) alignment points in the sealing product adapted to enable the heat sealing product and therefore the individual heat seals of the heat sealing product to be aligned substantially exactly with respect to the individual containers to be sealed.

The present invention relates to the field of biomedical technology and discloses a cartridge and a testing device. The cartridge comprises a sample lysis compartment, a first sample mixing compartment and a first PCR compartment; a first valve is disposed between the sample lysis compartment and the first sample mixing compartment, the first valve controls the flowing or blocking of the sample between the sample lysis compartment and the first sample mixing compartment; a fourth valve is disposed between the first PCR compartment and the first sample mixing compartment, the fourth valve controls the flow or blocking of the sample between the first sample mixing compartment and the first PCR compartment; a first reagent is provided in the first sample mixing compartment. In the compartment, nucleic acids in the sample mix with the first reagent and is then sent to the first PCR compartment for amplification.

A sampling structure, a sealing structure and a detection assembly are provided. The sampling structure includes a first main body, a second main body and a third main body. The first main body includes a first channel, the first channel includes a first opening that is exposed. The second main body is connected to the first main body and includes a second channel and at least one partition column located in the second channel, the second channel is linked with the first channel, and a first gap is between the partition column and a channel wall of the second channel. The third main body is connected to the second main body and includes a chamber, the chamber is linked with the second channel and is capable of containing a sample.

In an example implementation, a reagent storage system for a microfluidic device includes a microfluidic chamber formed in a microfluidic device. A blister pack to store a reagent includes an electrically conductive membrane barrier adjacent to the chamber. A thinned region is formed in the membrane barrier, and a conductive trace is to supply electric current to heat and melt the thinned region. Melting the thinned region is to cause the membrane barrier to open and release the reagent into the chamber.

Modular active surface devices for microfluidic systems and methods of making same is disclosed. In one example, the modular active surface device includes an active surface layer mounted atop an active surface substrate, a mask mounted atop the active surface layer wherein the mask defines the area, height, and volume of the reaction chamber, and a substrate mounted atop the mask wherein the substrate provides the facing surface to the active surface layer. In other examples, both facing surfaces of the reaction chamber include active surface layers. Further, the modular active surface device can include other layers, such as, but not limited to, adhesive layers, stiffening layers for facilitating handling, and peel-off sealing layers. Further, a large-scale manufacturing method is provided of mass-producing the modular active surface devices. Further, a method is provided of using a plasma bonding process to bond the active surface layer to the active surface substrate.