Provided are nanoparticles for sensing phosphate, a method for manufacturing the same, and a membrane for sensing phosphate including the same. The nanoparticles for sensing phosphate include a coordination polymer in which lanthanide metal ions and ligands are coordinated, and a polymer.

A test tube for testing fluid absorption of a sample material includes an elongated tubular portion configured to contain a test fluid and a base portion for receiving and holding the sample material. The base portion is in fluid communication with the elongated tubular portion and configured to support the elongated tubular portion when the test tube is in an upright position with the base portion placed on a surface. The test tube is configured such that when the sample material is received in the base portion and the test tube is placed in the upright position for a fluid absorption test, the test fluid contained in the elongated tubular portion makes contact with the sample material.

A test strip for sampling a bodily fluid may include multiple layers of a substrate material, an adhesive between at least some of the multiple layers, and a microfluidic channel formed between at least some of the multiple layers. The test strip may further include multiple electrodes on one of the multiple layers, positioned and partially exposed within the microfluidic channel, an additional material positioned at or near an entrance to the microfluidic channel, to selectively limit the flow of at least one of bubbles or debris into the microfluidic channel, and at least one exit port in at least one of the multiple layers to allow for release of pressure from the test strip. In some embodiments, the test strip is a saliva analysis test strip. In some embodiments, the test strip includes multiple exit ports to prevent blockage of sample flow.

A method of producing a microfluidic device, including providing at least two solid layers and at least one reagent disc comprising a support disc carrying at least one dry reagent, arranging the reagent disk(s) and stacking the solid layers to form a microfluidic channel arrangement including at least one opening into a channel of the microfluidic channel arrangement and wherein the reagent disk(s) is located in the microfluidic channel arrangement.

A passive sampling device is provided that is comprised of a member having a first surface and a second surface opposite the first surface and a hole through the member extending from the first surface to the second surface. An adsorbent material is positioned between two mesh members. The adsorbent material allows for efficient and selective removal of organic molecules, such as, for example, perfluoroalkyl substances.

The present invention provides a pipette tip, which can be used in in-vitro diagnostics, in particular in the diagnostic testing of body fluids, such as in coagulation testing. The Pipette tip contains two constituents in a spatially separated manner. The present invention furthermore provides a method of performing such diagnostics, e.g. coagulation analysis, and to the use of the pipette tip in such diagnostic testing.

Implementations of a method for seeding sequence libraries on a surface of a sequencing flow cell that allow for spatial segregation of the libraries on the surface are provided. The spatial segregation can be used to index sequence reads from individual sequencing libraries to increase efficiency of subsequent data analysis. In some examples, hydrogel beads containing encapsulated sequencing libraries are captured on a sequencing flow cell and degraded in the presence of a liquid diffusion barrier to allow for the spatial segregation and seeding of the sequencing libraries on the surface of the flow cell. Additionally, examples of systems, methods and compositions are provided relating to flow cell devices configured for nucleic acid library preparation and single cell sequencing. Some examples include flow cell devices having a hydrogel with genetic material disposed therein, and which is retained within the hydrogel during nucleic acid processing.

Present invention is related to a tumor microenvironment on chip or a biochip for cell therapy having a carrier, a first cell or tissue culture area and a second cell or tissue area imbedded within the carrier. The present invention provides a biochip successfully cooperating micro fluidic technology and cell culture achieving the goal for detecting or testing the function of cell therapy for cancer or tumor.

A portable diagnostic device for performing the diagnosis of pathogens, such as viruses, bacteria, microorganisms, etc., by rapidly detecting their nucleic acids in a biological sample to be tested. Also, the use of the portable diagnostic device and the methods for detection of at least one nucleic acid sequence of interest implemented with the aid of the portable diagnostic device.

A portable point of care device (1) for use in testing a biological sample, the device comprising: a sample collection member (4), a test cartridge (2), and a reader (220).