Provided is a membrane carrier for a liquid sample test kit (3) that detects a substance to be detected in a liquid sample, the liquid sample test kit including at least one flow path (2) capable of transporting the liquid sample, in which a microstructure that causes a capillary action for transporting the liquid sample is provided on a bottom surface of the flow path (2), and a level difference at which a height level of the bottom surface changes, is provided in the flow path (2). The membrane carrier preferably has a detection zone for detecting a substance to be detected in the liquid sample.

A leukocyte trapping apparatus configured so: a chip having protruding parts arranged on a flat part, a blood-containing solution that enters through an inlet port is allowed to pass through the surface of the flat part and through spaces between two adjacent protruding parts in the chip and is discharged through a discharge port; the protruding parts are arranged in layers on the flat part, layer containing a plurality of the protruding parts, and the blood-containing solution that has passed through a layer located on the inlet port side passes through another layer that is adjacent to the layer on the discharge port side; a trapping part and a bypass part are between two adjacent protruding parts in each layer; and the trapping part is on the discharge port side of the bypass part in a specific layer as a portion of another layer adjacent to the specific layer.

An analyte inspection apparatus is proposed. The apparatus may a body portion having one side open and a main space in which a sample is accommodated. The apparatus may also include a piston including one or more partition walls partitioning the main space, the piston being inserted into the main space of the body portion to be movable back and forth. The apparatus may further include an exchange flow path for providing a passage for the sample to flow. The exchange flow path may communicate with any one of the plurality of compartments separated by the one or more partition walls depending on a position of the piston.

A support holder for a test device is disclosed, wherein the holder may include a base having a first plurality of sidewalls having a first length and a second plurality of sidewalls having a second length, wherein the second length is greater than the first length, wherein the plurality of sidewalls define a cavity in the base, the cavity including a surface for receiving a portion of the test device; and a plurality of projections extending away from the base, wherein each projection of the plurality of projections is configured to be associated with a leg portion, and wherein a first sidewall of the first plurality of sidewalls includes a center notch positioned between a first corner portion and a second corner portion, and wherein a second sidewall of the first plurality of sidewalls includes a removable portion configured to cover an opening into an interior of the base.

A tissue embedding cassette has a box defining an inner cavity. A shield has a transparent plate body, the shield for being applied against a surface of the box. Complementary connectors for the shield to be held against the surface of the box. An assembly for a tissue embedding cassette of the type having a box defining an inner cavity may include a lid adapted to be operatively connected to the box, the lid opening and closing access to the inner cavity of the box. A shield has a transparent plate body, the shield configured for being applied against a surface of the box. Complementary connectors on the lid and/or the shield, for the shield to be held against the surface of the box.

Among other thing, the present invention provides solution to the problem, particularly, the present invention certain surfaces and certain sample holder to improve the sensitivity, speed, and easy-to-use of an optical signal based assays, such as colorimetric assays or fluorescence assays.

Lateral flow devices, methods and kits for performing lateral flow assays are provided.

An exemplary mobile impedance-based flow cytometer is developed for the diagnosis of sickle cell disease. The mobile cytometer may be controlled by a computer (e.g., smartphone) application. Calibration of the portable device may be performed using a component of known impedance value. With the developed portable flow cytometer, analysis may be performed on two sickle cell samples and a healthy cell sample. The acquired results may subsequently be analyzed to extract single-cell level impedance information as well as statistics of different cell conditions. Significant differences in cell impedance signals may be observed between sickle cells and normal cells, as well as between sickle cells under hypoxia and normoxia conditions.

Provided herein is a nucleic acid extraction and the structure of a reaction chamber is improved such that a piston, a reaction chamber and a magnetic rod are independent of one another, magnetic beads are more concentrated, more sufficient adsorption, washing and elution are achieved, dead corners are eliminated, when the nucleic acid extraction and amplification device is used to perform nucleic acid extraction and amplification. The sensitivity and accuracy of nucleic acid detection can be further improved, and missing and wrong detection can be avoided.

The present disclosure is drawn to loop-mediated isothermal amplification (LAMP) reaction assemblies including a substantially hygroscopic agent free LAMP reagent mixture in combination with a solid-phase reaction medium. The present disclosure also includes systems for a chromatic LAMP analysis including a substantially non-reactive solid phase reaction medium, and a non-interfering reagent mixture. The present disclosure also includes solid phase LAMP reaction mediums comprising a substrate, an adhesive layer disposed on the substrate, a reaction layer disposed on the adhesive layer, and a spreading layer disposed on the reaction layer. The present disclosure also includes methods of testing for a presence of a target nucleotide sequence including providing a biological sample, and dispensing the sample into a test environment having a solid phase reaction medium in combination with a LAMP reagent mixture and a pH sensitive dye.